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Protein
Submitted name:

Insulin-like growth factor I

Gene

Igf1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor IImported
Gene namesi
Name:Igf1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:96432. Igf1.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 143111Sequence analysisPRO_5003242978Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiE9PU89.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020053.
ExpressionAtlasiE9PU89. baseline and differential.
GenevisibleiE9PU89. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056668.

Structurei

3D structure databases

ProteinModelPortaliE9PU89.
SMRiE9PU89. Positions 34-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 9359IlGFInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
GeneTreeiENSGT00530000063856.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PU89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPAIKIHI MSSSHLFYLA LCLLTFTSST TAGPETLCGA ELVDALQFVC
60 70 80 90 100
GPRGFYFNKP TGYGSSIRRA PQTGIVDECC FRSCDLRRLE MYCAPLKPTK
110 120 130 140
AARSIRAQRH TDMPKTQKSP SLSTNKKTKL QRRRKGSTFE EHK
Length:143
Mass (Da):15,992
Last modified:April 5, 2011 - v1
Checksum:iE3242F4BA7C15440
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125082 Genomic DNA. No translation available.
AC139754 Genomic DNA. No translation available.
RefSeqiNP_001104744.1. NM_001111274.1.
UniGeneiMm.268521.

Genome annotation databases

EnsembliENSMUST00000122100; ENSMUSP00000112878; ENSMUSG00000020053.
GeneIDi16000.
UCSCiuc007gra.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125082 Genomic DNA. No translation available.
AC139754 Genomic DNA. No translation available.
RefSeqiNP_001104744.1. NM_001111274.1.
UniGeneiMm.268521.

3D structure databases

ProteinModelPortaliE9PU89.
SMRiE9PU89. Positions 34-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056668.

Proteomic databases

PaxDbiE9PU89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000122100; ENSMUSP00000112878; ENSMUSG00000020053.
GeneIDi16000.
UCSCiuc007gra.2. mouse.

Organism-specific databases

CTDi3479.
MGIiMGI:96432. Igf1.

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
GeneTreeiENSGT00530000063856.

Miscellaneous databases

ChiTaRSiIgf1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020053.
ExpressionAtlasiE9PU89. baseline and differential.
GenevisibleiE9PU89. MM.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PU89_MOUSE
AccessioniPrimary (citable) accession number: E9PU89
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.