E9PU15 (E9PU15_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Dicer1 Ensembl ENSRNOP00000014405

Submitted name:
RCG20888 EMBL EDL81806.1

Gene names

Name:	Dicer1 Ensembl ENSRNOP00000014405
ORF Names:	rCG_20888 EMBL EDL81806.1

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000014405

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1918 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase RuleBase RU000452 Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from electronic annotation. Source: Compara apoptotic process Inferred from electronic annotation. Source: Compara branching morphogenesis of an epithelial tube Inferred from electronic annotation. Source: Compara cardiac muscle cell development Inferred from electronic annotation. Source: Compara cerebral cortex development Inferred from electronic annotation. Source: Compara defense response to virus Inferred from electronic annotation. Source: Compara embryonic hindlimb morphogenesis Inferred from electronic annotation. Source: Compara hair follicle cell proliferation Inferred from electronic annotation. Source: Compara hair follicle morphogenesis Inferred from electronic annotation. Source: Compara inner ear receptor cell development Inferred from electronic annotation. Source: Compara intestinal epithelial cell development Inferred from electronic annotation. Source: Compara lung development Inferred from electronic annotation. Source: Compara multicellular organism growth Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara olfactory bulb interneuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of miRNA metabolic process Inferred from electronic annotation. Source: Compara positive regulation of myelination Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara post-embryonic development Inferred from electronic annotation. Source: Compara pre-miRNA processing Inferred from electronic annotation. Source: Compara production of siRNA involved in RNA interference Inferred from electronic annotation. Source: Compara regulation of cell cycle Inferred from electronic annotation. Source: Compara regulation of enamel mineralization Inferred from electronic annotation. Source: Compara regulation of neuron differentiation Inferred from electronic annotation. Source: Compara regulation of oligodendrocyte differentiation Inferred from electronic annotation. Source: Compara regulation of viral genome replication Inferred from electronic annotation. Source: Compara spinal cord motor neuron differentiation Inferred from electronic annotation. Source: Compara spindle assembly Inferred from electronic annotation. Source: Compara spleen development Inferred from electronic annotation. Source: Compara stem cell maintenance Inferred from electronic annotation. Source: Compara targeting of mRNA for destruction involved in RNA interference Inferred from electronic annotation. Source: Compara zygote asymmetric cell division Inferred from electronic annotation. Source: Compara
Cellular_component	RNA-induced silencing complex Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro double-stranded RNA binding Inferred from electronic annotation. Source: Compara miRNA binding Inferred from electronic annotation. Source: Compara ribonuclease III activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E9PU15 [UniParc]. Last modified April 3, 2013. Version 2. Checksum: 88334E0873153397	FASTA	1,918	216,890
	10 20 30 40 50 60 MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALDHNT 70 80 90 100 110 120 IVCLNTGSGK TFIAVLLTKE LAHQIRGDLS PHAKRTVFLV NSANQVAQQV SAVRTHSDLK 130 140 150 160 170 180 VGEYSNLEVN ASWTKERWSQ EFTKHQVLIM TCYVALNVLK NGYLSLSDIN LLVFDECHLA 190 200 210 220 230 240 ILDHPYREIM KLCDSCPSCP RILGLTASIL NGKCDPDELE EKIQKLEKIL KSGAETATDL 250 260 270 280 290 300 VVLDRYTSQP CEIVVDCGPF TDRSGLYERL LMELEEALDF INDCNVSVHS KERDSTLISK 310 320 330 340 350 360 QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT LLRKIHALCE 370 380 390 400 410 420 EYFSPASLDL KYVTPKVMKL LEILRKYKPY ERQQFESVEW YNNRNQDNYV SWSDSEDDDD 430 440 450 460 470 480 DEEIEEKEKP ETNFPSPFTN ILCGIIFVER RYTAVVLNRL IKEAGKQDPE LAYISSNFIT 490 500 510 520 530 540 GHGIGKNQPR SKQMEAEFRK QEEVLRKFRA HETNLLIATS VVEEGVDIPK CNLVVRFDLP 550 560 570 580 590 600 TEYRSYVQSK GRARAPISNY VMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSVDGAEAD 610 620 630 640 650 660 VHAVVDDDDV FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA PKCRTRELPD 670 680 690 700 710 720 GTFYSTLYLP INSPLRASIV GPPMGCVRLA ERVVALICCE KLHKIGELDE HLMPVGKETV 730 740 750 760 770 780 KYEEELDLHD EEETSVPGRP GSTKRRQCYP KAIPECLRES YPKPDQPCYL YVIGMVLTTP 790 800 810 820 830 840 LPDELNFRRR KLYPPEDTTR CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFTLSQ 850 860 870 880 890 900 QMLELVTRLH QYIFSHILRL EKPALEFQPA GAESAYCVLP LNVVNDSSTL DIDFKFMEDI 910 920 930 940 950 960 EKSEARIGIP STKYSKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV YTDLTPLSKF 970 980 990 1000 1010 1020 PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL TPRHLNQKGK ALPLSSAEKR 1030 1040 1050 1060 1070 1080 KAKWESLQNK QILVPELCAI HPIPASLWRK AVCLPSILYR LHCLLTAEEL RAQTASDAGV 1090 1100 1110 1120 1130 1140 GVRSLPADFR YPNLDFGWKK SIDSKSFIST CNSSLAESDN YCKHSTTVVP ENAAHQGATR 1150 1160 1170 1180 1190 1200 PSLENHDQMS VNCKRLPAES PAKLQSEVSV DLTAINGLSY NKSLANGSYD LVNRDFCQGN 1210 1220 1230 1240 1250 1260 QLTYFKQEIP VQPTTSYPIQ NLYNYENQPT PSNECPLLSN KYLDGNANTS TSDGSPAGSP 1270 1280 1290 1300 1310 1320 RPAMMTAVEA LEGRTDSEQS PSVGHSSRTL GPNPGLILQA LTLSNASDGF NLERLEMLGD 1330 1340 1350 1360 1370 1380 SFLKHAITTY LFCTYPDAHE GRLSYMRSKK VSNCNLYRLG KKQGLPSRMV VSIFDPPVNW 1390 1400 1410 1420 1430 1440 LPPGYVVNQD KSNSEKWEKD EMTKDCLLAN GKLGEDCEEE EEEELAWRAP KEEAEYEDDL 1450 1460 1470 1480 1490 1500 LEYDQEHIQF IDSMLMGSGA FVKKIPLSPF STSDSAYEWK MPKKASLGSV PFSSDLEDFD 1510 1520 1530 1540 1550 1560 YSSWDAMCYL DPSKAVEEDD FVVGFWNPSE ENCGVDTGKQ SISYDLHTEQ CIADKSIADC 1570 1580 1590 1600 1610 1620 VEALLGCYLT SCGERAAQLF LCSLGLKVLP VIKRTSRDKA SYPAQENSSS QQKSPSGSCA 1630 1640 1650 1660 1670 1680 AAVSPRSSAG KDLEYGCLKI PPRCMFDHPD AEKTLNHLIS GFENFEKKIN YIFKNKAYLL 1690 1700 1710 1720 1730 1740 QAFTHASYHY NTITDCYQRL EFLGDAILDY LITKHLYEDP RQHSPGVLTD LRSALVNNTI 1750 1760 1770 1780 1790 1800 FASLAVKYDY HKYFKAVSPE LFHVIDDFVQ FQLEKNEMQG MDSELRRSEE DEEKEEDIEV 1810 1820 1830 1840 1850 1860 PKAMGDIFES LAGAIYMDSG MSLEVVWQVY YPMMRPLIEK FSANVPRSPV RELLEMEPET 1870 1880 1890 1900 1910 AKFSPAERTY DGKVRVTVEV VGKGKFKGVG RSYRIAKSAA ARRALRSLKA NQPLVPNS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000014405.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL81806.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL81806.1.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000014405.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06046035 Genomic DNA. No translation available. CH473982 Genomic DNA. Translation: EDL81806.1.
IPI	IPI00365891.
RefSeq	XP_001068155.1. XM_001068155.3. XP_001069041.1. XM_001069041.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000014405; ENSRNOP00000014405; ENSRNOG00000010711.
GeneID	299284.
Organism-specific databases
RGD	1309381. Dicer1.
Phylogenomic databases
GeneTree	ENSGT00510000046789.
Family and domain databases
Gene3D	1.10.1520.10. 4 hits.
InterPro	IPR005034. Dicer_dsRNA_binding_fold. IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR001159. Ds-RNA-bd. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR003100. PAZ. IPR000999. RNase_III_dom. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF03368. dsRNA_bind. 1 hit. PF00271. Helicase_C. 1 hit. PF02170. PAZ. 1 hit. PF00636. Ribonuclease_3. 2 hits. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00358. DSRM. 1 hit. SM00490. HELICc. 1 hit. SM00949. PAZ. 1 hit. SM00535. RIBOc. 2 hits. [Graphical view]
SUPFAM	SSF101690. PAZ. 1 hit. SSF69065. RNase_III. 2 hits.
PROSITE	PS51327. DICER_DSRBF. 1 hit. PS50137. DS_RBD. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50821. PAZ. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	35575236.

Entry information

Entry name

E9PU15_RAT

Accession

Primary (citable) accession number: E9PU15

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 3, 2013
Last modified:	May 1, 2013
This is version 19 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)