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Protein

Palmitoyltransferase ZDHHC17

Gene

Zdhhc17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg2+ transport.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei457S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC17Curated (EC:2.3.1.225By similarity)
Alternative name(s):
Zinc finger DHHC domain-containing protein 17Imported
Gene namesi
Name:Zdhhc17Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1595790. Zdhhc17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 294CytoplasmicCuratedAdd BLAST294
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 347LumenalCuratedAdd BLAST11
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 371CytoplasmicCurated3
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 470LumenalCuratedAdd BLAST78
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Topological domaini492 – 506CytoplasmicCuratedAdd BLAST15
Transmembranei507 – 526HelicalSequence analysisAdd BLAST20
Topological domaini527 – 529LumenalCurated3
Transmembranei530 – 552HelicalSequence analysisAdd BLAST23
Topological domaini553 – 622CytoplasmicCuratedAdd BLAST70

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004335131 – 622Palmitoyltransferase ZDHHC17Add BLAST622

Post-translational modificationi

Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg2+ transport.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiE9PTT0.
PeptideAtlasiE9PTT0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003803.

Interactioni

Subunit structurei

Interacts (via ANK repeats) with CLIP3 (By similarity). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725). Interacts (via ANK repeats) with HTT (By similarity). Interacts (via ANK repeats) with MAP6 (By similarity). Interacts (via ANK repeats) with SNAP23 (By similarity). Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005078.

Structurei

3D structure databases

SMRiE9PTT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 76ANK 1By similarityAdd BLAST36
Repeati79 – 108ANK 2Sequence analysisAdd BLAST30
Repeati113 – 142ANK 3Sequence analysisAdd BLAST30
Repeati146 – 175ANK 4Sequence analysisAdd BLAST30
Repeati179 – 209ANK 5Sequence analysisAdd BLAST31
Repeati214 – 243ANK 6Sequence analysisAdd BLAST30
Repeati247 – 276ANK 7Sequence analysisAdd BLAST30
Domaini427 – 477DHHCPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 295Necessary and sufficient for interaction with DNAJC5 and SNAP25By similarityAdd BLAST295

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
HOGENOMiHOG000290181.
HOVERGENiHBG051907.
InParanoidiE9PTT0.
KOiK20032.
OMAiQAKGYDS.
OrthoDBiEOG091G056H.
TreeFamiTF317342.

Family and domain databases

CDDicd00204. ANK. 2 hits.
Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Palmitoyltrfase_DHHC.
IPR030289. ZDHHC17.
PANTHERiPTHR24161:SF39. PTHR24161:SF39. 1 hit.
PfamiView protein in Pfam
PF12796. Ank_2. 2 hits.
PF01529. DHHC. 1 hit.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 5 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PTT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGPDEYDT ETGCVPLLHP EEIKPQSHYN HGYGEPLGRK THVDDYSTWD
60 70 80 90 100
IVKATQYGIY ERCRELVEAG YDVRQPDKEN VTLLHWAAIN NRIDLVKYYI
110 120 130 140 150
SKGAIVDQLG GDLNSTPLHW ATRQGHLSMV VQLMKYGADP SLIDGEGCSC
160 170 180 190 200
IHLAAQFGHT SIVAYLIAKG QDVDMMDQNG MTPLMWAAYR THSVDPTRLL
210 220 230 240 250
LTFNVSVNLG DKYHKNTALH WAVLAGNTTV ISLLLEAGGN VDAQNVKGES
260 270 280 290 300
ALDLAKQRKN VWMINHLQEA RQAKGYDNPS FLRKLKADKE FRQKVMLGTP
310 320 330 340 350
FLVIWLVGFI ADLNIDSWLI KGLMYGGVWA TVQFLSKSFF DHSMHSALPL
360 370 380 390 400
GIYLATKFWM YVTWFFWFWN DLSFLSIHLP FLANSVALFY NFGKSWKSDP
410 420 430 440 450
GIIKATEEQK KKTIVELAET GSLDLSIFCS TCLIRKPVRS KHCGVCNRCI
460 470 480 490 500
AKFDHHCPWV GNCVGAGNHR YFMGYLFFLL FMICWMIYGC VSYWGLHCET
510 520 530 540 550
TYTKDGFWTY ITQIATCSPW MFWMFLNSVF HFMWVAVLLM CQMYQITCLG
560 570 580 590 600
ITTNERMNAR RYKHFKVTTT SIESPFNHGC VRNIIDFFEF RCCGLFRPVI
610 620
VDWTRQYTIE YDQISGSGYQ LV
Length:622
Mass (Da):71,319
Last modified:April 5, 2011 - v1
Checksum:i845F70BCA572BE49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti465G → C in AAX73395 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886533 mRNA. Translation: AAX73395.1.
AABR06049566 Genomic DNA. No translation available.
AABR06049567 Genomic DNA. No translation available.
AABR06049568 Genomic DNA. No translation available.
RefSeqiNP_001034429.1. NM_001039340.1.
UniGeneiRn.162951.

Genome annotation databases

EnsembliENSRNOT00000005078; ENSRNOP00000005078; ENSRNOG00000003803.
GeneIDi366889.
KEGGirno:366889.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZDH17_RAT
AccessioniPrimary (citable) accession number: E9PTT0
Secondary accession number(s): Q2TGJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2015
Last sequence update: April 5, 2011
Last modified: July 5, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families