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Protein

Matrix metalloproteinase

Gene

Mmp2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei404UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationSAAS annotation, Protease
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-1442490. Collagen degradation.
R-RNO-1474228. Degradation of the extracellular matrix.
R-RNO-1592389. Activation of Matrix Metalloproteinases.
R-RNO-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-RNO-3928665. EPH-ephrin mediated repulsion of cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:Mmp2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621316. Mmp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29UniRule annotationAdd BLAST29
ChainiPRO_501101904330 – 663Matrix metalloproteinaseUniRule annotationAdd BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi233 ↔ 259PROSITE-ProRule annotation
Disulfide bondi247 ↔ 274PROSITE-ProRule annotation
Disulfide bondi291 ↔ 317PROSITE-ProRule annotation
Disulfide bondi305 ↔ 332PROSITE-ProRule annotation
Disulfide bondi349 ↔ 375PROSITE-ProRule annotation
Disulfide bondi363 ↔ 390PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation, ZymogenUniRule annotation

Proteomic databases

PaxDbiE9PSM5.
PeptideAtlasiE9PSM5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016695.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 276Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini286 – 334Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini344 – 392Fibronectin type-IIInterPro annotationAdd BLAST49
Repeati474 – 519HemopexinPROSITE-ProRule annotationAdd BLAST46
Repeati520 – 566HemopexinPROSITE-ProRule annotationAdd BLAST47
Repeati568 – 616HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati617 – 663HemopexinPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.
OMAiHESCTSA.
OrthoDBiEOG091G03DP.
TreeFamiTF315428.

Family and domain databases

CDDicd00062. FN2. 3 hits.
cd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di1.10.101.10. 1 hit.
2.10.10.10. 3 hits.
2.110.10.10. 2 hits.
InterProiView protein in InterPro
IPR028708. 72kDa_collagenase.
IPR000562. FN_type2_dom.
IPR036943. FN_type2_sf.
IPR000585. Hemopexin-like_dom.
IPR036375. Hemopexin-like_dom_sf.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR013806. Kringle-like.
IPR033739. M10A_MMP.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
IPR036365. PGBD-like_sf.
IPR036366. PGBDSf.
PANTHERiPTHR10201:SF29. PTHR10201:SF29. 4 hits.
PfamiView protein in Pfam
PF00040. fn2. 3 hits.
PF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 2 hits.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00059. FN2. 3 hits.
SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
SSF57440. SSF57440. 3 hits.
PROSITEiView protein in PROSITE
PS00546. CYSTEINE_SWITCH. 1 hit.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 3 hits.
PS00024. HEMOPEXIN. 2 hits.
PS51642. HEMOPEXIN_2. 4 hits.

Sequencei

Sequence statusi: Complete.

E9PSM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARLVWGVL VGPLRVLCVL CCLLGHAIAA PSPIIKFPGD VSPKTDKELA
60 70 80 90 100
VQYLNTFYGC PKESCNLFVL KDTLKKMQKF FGLPQTGDLD QNTIETMRKP
110 120 130 140 150
RCGNPDVANY NFFPRKPKWD KNQITYRIIG YTPDLDPETV DDAFARALKV
160 170 180 190 200
WSDVTPLRFS RIHDGEADIM INFGRWEHGD GYPFDGKDGL LAHAFAPGTG
210 220 230 240 250
VGGDSHFDDD ELWTLGEGQV VRVKYGNADG EYCKFPFLFN GREYSSCTDT
260 270 280 290 300
GRSDGFLWCS TTYNFEKDGK YGFCPHEALF TMGGNGDGQP CKFPFRFQGT
310 320 330 340 350
SYNSCTTEGR TDGYRWCGTT EDYDRDKKYG FCPETAMSTV GGNSEGAPCV
360 370 380 390 400
FPFTFLGNKY ESCTSAGRSD GKVWCATTTN YDDDRKWGFC PDQGYSLFLV
410 420 430 440 450
AAHEFGHAMG LEHSQDPGAL MAPIYTYTKN FRLSNDDIKG IQELYGPSPD
460 470 480 490 500
ADTDTGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT
510 520 530 540 550
PRDKPTGPLL VATSFWPELP EKIDAVYEAP QEEKAVFFAG NEYWVYSAST
560 570 580 590 600
LERGYPKPLT SLGLPPDVQQ VDAAFNWSKN KKTYIFSGDK FWRYNEVKKK
610 620 630 640 650
MDPGFPKLIA DSWNAIPDNL DAVVDLQGGG HSYFFKGAYY LKLENQSLKS
660
VKFGSIKSDW LGC
Length:663
Mass (Da):74,237
Last modified:July 22, 2015 - v3
Checksum:iF315B71CD1A1726E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07042987 Genomic DNA. No translation available.
AABR07042988 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000022679; ENSRNOP00000022679; ENSRNOG00000016695.

Similar proteinsi

Entry informationi

Entry nameiE9PSM5_RAT
AccessioniPrimary (citable) accession number: E9PSM5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: July 22, 2015
Last modified: October 25, 2017
This is version 63 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported