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Protein

Caspase

Gene

Casp4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei189UniRule annotation1
Active sitei237UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
CaspaseUniRule annotation
Gene namesi
Name:Casp4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621757. Casp4.

Subcellular locationi

GO - Cellular componenti

  • AIM2 inflammasome complex Source: GO_Central
  • IPAF inflammasome complex Source: GO_Central
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • NLRP1 inflammasome complex Source: Ensembl
  • NLRP3 inflammasome complex Source: GO_Central
  • protein complex Source: RGD

PTM / Processingi

Proteomic databases

PaxDbiE9PSM0.
PeptideAtlasiE9PSM0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000033697.

Interactioni

GO - Molecular functioni

  • scaffold protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058685.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 241CASPASE_P20InterPro annotationAdd BLAST129
Domaini269 – 354CASPASE_P10InterPro annotationAdd BLAST86

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
InParanoidiE9PSM0.
OMAiGMESEMK.
OrthoDBiEOG091G07NO.

Family and domain databases

CDDicd00032. CASc. 1 hit.
Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiView protein in InterPro
IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiView protein in SMART
SM00115. CASc. 1 hit.
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiView protein in PROSITE
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PSM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VGGELLREAD SWVTKHVLKL KEEEKQKFNN AERSDKRWVF VDVLKRKHNQ
60 70 80 90 100
VGKMLLQTFL NVDSGSHHGE ANLEMEEPEE SVDTLKLCSS EEFTRLCREK
110 120 130 140 150
KQEIYPIKET NGRTRKALII CNTEFKHLSL RYGANIDISG MKGLLEELGY
160 170 180 190 200
DVVVKEELTA EGMESEMKDF AALSEHQTSD STFLVLMSHG TLQGLCGTMH
210 220 230 240 250
SEATPDVLLY DTIYQIFNNC HCPGLRDKPK VIIVQACRGG NPGEVWIRES
260 270 280 290 300
SGAHSYRAVD LPRNMEADAV RMSHVEKDFI ALYSTTPHHL SYRDKTRGSY
310 320 330 340 350
FISKLISCFR IHACSCHLFD IFLKVQQSFE KASINSQMPT IDRATLTRYF

YLFPGN
Length:356
Mass (Da):40,653
Last modified:July 22, 2015 - v3
Checksum:i1FE190304929A3FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07068940 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000061973; ENSRNOP00000058685; ENSRNOG00000033697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07068940 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058685.

Proteomic databases

PaxDbiE9PSM0.
PeptideAtlasiE9PSM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000061973; ENSRNOP00000058685; ENSRNOG00000033697.

Organism-specific databases

RGDi621757. Casp4.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
InParanoidiE9PSM0.
OMAiGMESEMK.
OrthoDBiEOG091G07NO.

Gene expression databases

BgeeiENSRNOG00000033697.

Family and domain databases

CDDicd00032. CASc. 1 hit.
Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiView protein in InterPro
IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiView protein in SMART
SM00115. CASc. 1 hit.
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiView protein in PROSITE
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiE9PSM0_RAT
AccessioniPrimary (citable) accession number: E9PSM0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: July 22, 2015
Last modified: March 15, 2017
This is version 50 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.