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E9PSK0

- E9PSK0_RAT

UniProt

E9PSK0 - E9PSK0_RAT

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Protein

Alpha-mannosidase

Gene

Man2b2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Cofactori

Note: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. alpha-mannosidase activity Source: RGD
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. mannose metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:Man2b2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 14

Organism-specific databases

RGDi1308840. Man2b2.

Subcellular locationi

GO - Cellular componenti

  1. lysosome Source: RGD
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00510000046304.
InParanoidiE9PSK0.
OMAiMRAYAAN.
OrthoDBiEOG7RFTGG.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PSK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLLRWLPLL GQLLLLWPLA ARPASPIRAF VVPHSHMDVG WVYTVQESMR
60 70 80 90 100
AYAANVYTTV VEELVRGRQR RFIAVEQEFF RLWWDGVASE QQKQQVRQLL
110 120 130 140 150
DEGRLEFVLG GQVMHDEAVT HLDDQILQLT EGHGFLYETF GIRPQFSWHV
160 170 180 190 200
DPFGASATTP TLFALAGFNA HLISRIDYDL KDAMQEAQGL QFVWHGSPSL
210 220 230 240 250
SEQQEIYTHV MDLYSYCTPS HIPFSNRSGF YWNGVAVFPE PPPDGVYPNM
260 270 280 290 300
SEPVTVDNIH LYAEALVANV KQRAAWFRTP HVLWPWGCDK QFFNASVQFD
310 320 330 340 350
NMDPLLEYIN NRSAQFGISV QYATLNDYFQ ALHDFNVTWD IRDHHDFLPY
360 370 380 390 400
SSEPQQAWTG FFTSRSTLKG LARQASALLY AGESMFTRYM WPHPRGTLDP
410 420 430 440 450
TWALQQLQQL RWAVSEVQHH DAITGTESPK VKNMYMEHLS MGMRGVHKLM
460 470 480 490 500
ASIALDRPPG SGTDTRPVGY SASVYNPLAW KITTIITLTV AFPSVSVTDE
510 520 530 540 550
LGRPVSAQIQ NSTKDPSAYD LLILTTIPGL SYRHYKVRRT RGDQAGTREL
560 570 580 590 600
VTPRANTLKF SRKLRNQTSQ EGKLLVPVMN DCYTLLFDQD TNMLHSIQDR
610 620 630 640 650
QSNRTVHMTQ EFLEYRANGD VKQGPISDNY LFASNDTAEP SWEAVGMEMV
660 670 680 690 700
VGTLATDVRQ YFYRNITDQG YIYSIHTRLA HVHPSLAGEL LCRRIEQQYQ
710 720 730 740 750
VGPLDLNREA ILRTSSDLNS QQVLYSDNNG YQMQRRPYKA FKSNPIPRNY
760 770 780 790 800
YPMVQSAFIE DDKSRLVLLA ERPHGVSSQE NGQVEVMLHR RLWNNLVWDL
810 820 830 840 850
NYNLTLNDTS VVHPVLWLLL GPKSTTTALR PRSGVALQHR PVVLLKELTD
860 870 880 890 900
EEETAIHRPH HPWPVTLPPS LHLQVLSLPG WQYSRNHAQH LKNLQRGHPE
910 920 930 940 950
KPQVNLQRVL LRLHHLYEAG EDPVLSRPAT VDLKIALRGL GSVVAVEERS
960 970 980
LTGTWDVQTL QRWHWRTKIG QLKGDPWISL P
Length:981
Mass (Da):112,271
Last modified:April 5, 2011 - v1
Checksum:i1A39EB1DA40DE194
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06080329 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000064548; ENSRNOP00000062052; ENSRNOG00000005526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06080329 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000064548 ; ENSRNOP00000062052 ; ENSRNOG00000005526 .

Organism-specific databases

RGDi 1308840. Man2b2.

Phylogenomic databases

GeneTreei ENSGT00510000046304.
InParanoidi E9PSK0.
OMAi MRAYAAN.
OrthoDBi EOG7RFTGG.

Miscellaneous databases

NextBioi 35574766.

Family and domain databases

Gene3Di 1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 1 hit.
InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view ]
Pfami PF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view ]
SMARTi SM00872. Alpha-mann_mid. 1 hit.
[Graphical view ]
SUPFAMi SSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiE9PSK0_RAT
AccessioniPrimary (citable) accession number: E9PSK0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3