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Protein

Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)

Gene

DHDDS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).UniRule annotation

Catalytic activityi

(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55).UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)UniRule annotation (EC:2.5.1.87UniRule annotation)
Gene namesi
Name:DHDDSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20603. DHDDS.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000117682.

PTM / Processingi

Proteomic databases

MaxQBiE9PRS7.
PaxDbiE9PRS7.
PeptideAtlasiE9PRS7.

Expressioni

Gene expression databases

BgeeiENSG00000117682.
ExpressionAtlasiE9PRS7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353104.

Structurei

3D structure databases

ProteinModelPortaliE9PRS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1602. Eukaryota.
COG0020. LUCA.
GeneTreeiENSGT00390000007879.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
InterProiIPR001441. UPP_synth-like.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.

Sequencei

Sequence statusi: Fragment.

E9PRS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWIKEGELS LWERFCANII KAGPMPKHIA FIMDGNRRYA KKCQVERQEG
60 70 80 90 100
HSQGFNKLAE TLRWCLNLGI LEVTVYAFSI ENFKRSKSEV DGLMDLARQK
110 120
FSRLMEEKEK LQKHGVCIRV LG
Length:122
Mass (Da):14,191
Last modified:April 5, 2011 - v1
Checksum:i0CF2E07DB3AF8039
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei122Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513365 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000525165; ENSP00000434185; ENSG00000117682.
UCSCiuc057drl.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513365 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PRS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353104.

Proteomic databases

MaxQBiE9PRS7.
PaxDbiE9PRS7.
PeptideAtlasiE9PRS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000525165; ENSP00000434185; ENSG00000117682.
UCSCiuc057drl.1. human.

Organism-specific databases

HGNCiHGNC:20603. DHDDS.
OpenTargetsiENSG00000117682.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1602. Eukaryota.
COG0020. LUCA.
GeneTreeiENSGT00390000007879.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

ChiTaRSiDHDDS. human.

Gene expression databases

BgeeiENSG00000117682.
ExpressionAtlasiE9PRS7. baseline and differential.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
InterProiIPR001441. UPP_synth-like.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiE9PRS7_HUMAN
AccessioniPrimary (citable) accession number: E9PRS7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.