E9PRS4 (E9PRS4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Alpha-crystallin B chain Ensembl ENSP00000435931

Gene names

Name:

CRYAB Ensembl ENSP00000435931

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000435931

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	69 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000435931

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aging Inferred from electronic annotation. Source: Compara apoptotic process involved in morphogenesis Inferred from electronic annotation. Source: Compara glucose metabolic process Inferred from electronic annotation. Source: Compara lens development in camera-type eye Inferred from electronic annotation. Source: Compara microtubule polymerization or depolymerization Inferred from electronic annotation. Source: Compara muscle organ development Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of gene expression Inferred from electronic annotation. Source: Compara negative regulation of reactive oxygen species metabolic process Inferred from electronic annotation. Source: Compara protein folding Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara stress-activated MAPK cascade Inferred from electronic annotation. Source: Compara tubulin complex assembly Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara Z disc Inferred from electronic annotation. Source: Compara actin filament bundle Inferred from electronic annotation. Source: Compara cell surface Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara microtubule cytoskeleton Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	structural constituent of eye lens Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	69	1	Ensembl ENSP00000435931

Sequences

	Sequence		Length	Mass (Da)
	E9PRS4 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: E7405C982E7D38D2	FASTA	69	8,211
	10 20 30 40 50 60 MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW FDTGLSEMR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000907 Genomic DNA. No translation available.
IPI	IPI00975518.
3D structure databases
ProteinModelPortal	E9PRS4.
SMR	E9PRS4. Positions 1-69.
ModBase	Search...
Proteomic databases
PRIDE	E9PRS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000533879; ENSP00000435931; ENSG00000109846.
Organism-specific databases
HGNC	HGNC:2389. CRYAB.
GenAtlas	Search...
Gene expression databases
ArrayExpress	E9PRS4.
Bgee	E9PRS4.
Family and domain databases
InterPro	IPR001436. Alpha-crystallin/HSP. IPR012273. Alpha-crystallin_B. IPR003090. Alpha-crystallin_N. [Graphical view]
PANTHER	PTHR11527:SF37. PTHR11527:SF37. 1 hit.
Pfam	PF00525. Crystallin. 1 hit. [Graphical view]
PRINTS	PR00299. ACRYSTALLIN.
ProtoNet	Search...
Other
ChiTaRS	CRYAB. human.
NextBio	35504764.

Entry information

Entry name

E9PRS4_HUMAN

Accession

Primary (citable) accession number: E9PRS4

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	April 3, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.