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Protein

Non-specific serine/threonine protein kinase

Gene

SGK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiE9PR89

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
Gene namesi
Name:SGK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118515.11
HGNCiHGNC:10810 SGK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118515

PTM / Processingi

Proteomic databases

MaxQBiE9PR89
PRIDEiE9PR89

Expressioni

Gene expression databases

BgeeiENSG00000118515
ExpressionAtlasiE9PR89 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PR89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 311Protein kinaseInterPro annotationAdd BLAST311
Domaini312 – 387AGC-kinase C-terminalInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00890000139324

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

E9PR89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK
60 70 80 90 100
HPEVQSILKI SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF
110 120 130 140 150
LKVIGKGSFG KVLLARHKAE EVFYAVKVLQ KKAILKKKEL FYHLQRERCF
160 170 180 190 200
LEPRARFYAA EIASALGYLH SLNIVYRDLK PENILLDSQG HIVLTDFGLC
210 220 230 240 250
KENIEHNSTT STFCGTPEYL APEVLHKQPY DRTVDWWCLG AVLYEMLYGL
260 270 280 290 300
PPFYSRNTAE MYDNILNKPL QLKPNITNSA RHLLEGLLQK DRTKRLGAKD
310 320 330 340 350
DFMEIKSHVF FSLINWDDLI NKKITPPFNP NVSGPNDLRH FDPEFTEEPV
360 370 380
PNSIGKSPDS VLVTASVKEA AEAFLGFSYA PPTDSFL
Length:387
Mass (Da):43,811
Last modified:April 5, 2011 - v1
Checksum:i34775AE13C3052D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135839 Genomic DNA No translation available.
AL355881 Genomic DNA No translation available.
KF458297 Genomic DNA No translation available.
Z84486 Genomic DNA No translation available.
RefSeqiNP_001278924.1, NM_001291995.1
UniGeneiHs.510078

Genome annotation databases

EnsembliENST00000475719; ENSP00000434302; ENSG00000118515
GeneIDi6446
UCSCiuc011ecu.3 human

Similar proteinsi

Entry informationi

Entry nameiE9PR89_HUMAN
AccessioniPrimary (citable) accession number: E9PR89
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health