Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Serine/threonine-protein kinase Sgk1

Gene

SGK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiE9PR89.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase Sgk1Imported
Gene namesi
Name:SGK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118515.11.
HGNCiHGNC:10810. SGK1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118515.

PTM / Processingi

Proteomic databases

MaxQBiE9PR89.
PRIDEiE9PR89.

Expressioni

Gene expression databases

BgeeiENSG00000118515.
ExpressionAtlasiE9PR89. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PR89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 311Protein kinaseInterPro annotationAdd BLAST311
Domaini312 – 387AGC-kinase C-terminalInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00890000139324.

Family and domain databases

InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
SMARTiView protein in SMART
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PR89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK
60 70 80 90 100
HPEVQSILKI SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF
110 120 130 140 150
LKVIGKGSFG KVLLARHKAE EVFYAVKVLQ KKAILKKKEL FYHLQRERCF
160 170 180 190 200
LEPRARFYAA EIASALGYLH SLNIVYRDLK PENILLDSQG HIVLTDFGLC
210 220 230 240 250
KENIEHNSTT STFCGTPEYL APEVLHKQPY DRTVDWWCLG AVLYEMLYGL
260 270 280 290 300
PPFYSRNTAE MYDNILNKPL QLKPNITNSA RHLLEGLLQK DRTKRLGAKD
310 320 330 340 350
DFMEIKSHVF FSLINWDDLI NKKITPPFNP NVSGPNDLRH FDPEFTEEPV
360 370 380
PNSIGKSPDS VLVTASVKEA AEAFLGFSYA PPTDSFL
Length:387
Mass (Da):43,811
Last modified:April 5, 2011 - v1
Checksum:i34775AE13C3052D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135839 Genomic DNA. No translation available.
AL355881 Genomic DNA. No translation available.
KF458297 Genomic DNA. No translation available.
Z84486 Genomic DNA. No translation available.
RefSeqiNP_001278924.1. NM_001291995.1.
UniGeneiHs.510078.

Genome annotation databases

EnsembliENST00000475719; ENSP00000434302; ENSG00000118515.
GeneIDi6446.
UCSCiuc011ecu.3. human.

Similar proteinsi

Entry informationi

Entry nameiE9PR89_HUMAN
AccessioniPrimary (citable) accession number: E9PR89
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 27, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported