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Protein
Submitted name:

Serine/threonine-protein kinase Chk1

Gene

CHEK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histone kinase activity (H3-T11 specific) Source: Ensembl

GO - Biological processi

  1. cellular response to caffeine Source: Ensembl
  2. chromatin-mediated maintenance of transcription Source: Ensembl
  3. DNA damage checkpoint Source: Ensembl
  4. DNA damage induced protein phosphorylation Source: Ensembl
  5. DNA repair Source: Ensembl
  6. G2/M transition of mitotic cell cycle Source: Ensembl
  7. negative regulation of DNA biosynthetic process Source: Ensembl
  8. negative regulation of G2/M transition of mitotic cell cycle Source: Ensembl
  9. regulation of cell proliferation Source: Ensembl
  10. regulation of histone H3-K9 acetylation Source: Ensembl
  11. regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiE9PQW7.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase Chk1Imported
Gene namesi
Name:CHEK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1925. CHEK1.

Subcellular locationi

GO - Cellular componenti

  1. chromatin Source: Ensembl
  2. nucleus Source: Ensembl
  3. replication fork Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9PQW7.
ExpressionAtlasiE9PQW7. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliE9PQW7.
SMRiE9PQW7. Positions 2-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00730000111032.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PQW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE
60 70 80 90 100
NIKKEICINK MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI
110 120
GMPEPDAQRF FHQLMAGVVY LHGIGIT
Length:127
Mass (Da):14,430
Last modified:April 5, 2011 - v1
Checksum:i1D182B40930BF138
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei127 – 1271Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001132 Genomic DNA. No translation available.
KF455559 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000534685; ENSP00000432470; ENSG00000149554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001132 Genomic DNA. No translation available.
KF455559 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PQW7.
SMRiE9PQW7. Positions 2-127.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiE9PQW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000534685; ENSP00000432470; ENSG00000149554.

Organism-specific databases

HGNCiHGNC:1925. CHEK1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000111032.

Enzyme and pathway databases

SignaLinkiE9PQW7.

Miscellaneous databases

ChiTaRSiCHEK1. human.
NextBioi35504515.

Gene expression databases

BgeeiE9PQW7.
ExpressionAtlasiE9PQW7. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PQW7_HUMAN
AccessioniPrimary (citable) accession number: E9PQW7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationMaxQB annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.