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E9PQW7

- E9PQW7_HUMAN

UniProt

E9PQW7 - E9PQW7_HUMAN

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Protein
Submitted name:

Serine/threonine-protein kinase Chk1

Gene
CHEK1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histone kinase activity (H3-T11 specific) Source: Ensembl

GO - Biological processi

  1. cellular response to caffeine Source: Ensembl
  2. chromatin-mediated maintenance of transcription Source: Ensembl
  3. DNA damage checkpoint Source: Ensembl
  4. DNA damage induced protein phosphorylation Source: Ensembl
  5. DNA repair Source: Ensembl
  6. G2/M transition of mitotic cell cycle Source: Ensembl
  7. regulation of cell proliferation Source: Ensembl
  8. regulation of histone H3-K9 acetylation Source: Ensembl
  9. regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiE9PQW7.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase Chk1Imported
Gene namesi
Name:CHEK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1925. CHEK1.

Subcellular locationi

GO - Cellular componenti

  1. chromatin Source: Ensembl
  2. nucleus Source: Ensembl
  3. replication fork Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiE9PQW7.
BgeeiE9PQW7.

Structurei

3D structure databases

ProteinModelPortaliE9PQW7.
SMRiE9PQW7. Positions 2-127.

Family & Domainsi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PQW7-1 [UniParc]FASTAAdd to Basket

« Hide

MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE    50
NIKKEICINK MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI 100
GMPEPDAQRF FHQLMAGVVY LHGIGIT 127
Length:127
Mass (Da):14,430
Last modified:April 5, 2011 - v1
Checksum:i1D182B40930BF138
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei127 – 1271Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001132 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000534685; ENSP00000432470; ENSG00000149554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001132 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9PQW7.
SMRi E9PQW7. Positions 2-127.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000534685 ; ENSP00000432470 ; ENSG00000149554 .

Organism-specific databases

HGNCi HGNC:1925. CHEK1.
GenAtlasi Search...

Enzyme and pathway databases

SignaLinki E9PQW7.

Miscellaneous databases

ChiTaRSi CHEK1. human.
NextBioi 35504515.

Gene expression databases

ArrayExpressi E9PQW7.
Bgeei E9PQW7.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PQW7_HUMAN
AccessioniPrimary (citable) accession number: E9PQW7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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