ID   E9PQL4_HUMAN            Unreviewed;       159 AA.
AC   E9PQL4;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=SRY-box transcription factor 6 {ECO:0000313|Ensembl:ENSP00000436170.1};
DE   Flags: Fragment;
GN   Name=SOX6 {ECO:0000313|Ensembl:ENSP00000436170.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436170.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436170.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [3] {ECO:0007829|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [4] {ECO:0000313|Ensembl:ENSP00000436170.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AC009869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC013595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC026639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC100865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC103794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E9PQL4; -.
DR   MassIVE; E9PQL4; -.
DR   PeptideAtlas; E9PQL4; -.
DR   ProteomicsDB; 23051; -.
DR   Antibodypedia; 1097; 343 antibodies from 33 providers.
DR   Ensembl; ENST00000533411.5; ENSP00000436170.1; ENSG00000110693.19.
DR   UCSC; uc057zjz.1; human.
DR   HGNC; HGNC:16421; SOX6.
DR   VEuPathDB; HostDB:ENSG00000110693; -.
DR   GeneTree; ENSGT00940000156433; -.
DR   OMA; GDKAMNG; -.
DR   ChiTaRS; SOX6; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000110693; Expressed in epithelial cell of pancreas and 168 other cell types or tissues.
DR   ExpressionAtlas; E9PQL4; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   PANTHER; PTHR45789; FI18025P1; 1.
DR   PANTHER; PTHR45789:SF1; TRANSCRIPTION FACTOR SOX-6; 1.
PE   1: Evidence at protein level;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:E9PQL4,
KW   ECO:0007829|ProteomicsDB:E9PQL4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         159
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000436170.1"
SQ   SEQUENCE   159 AA;  17842 MW;  02ED44D3B2A502EB CRC64;
     MSSKQATSPF ACAADGEDAM TQDLTSREKE EGSDQHVASH LPLHPIMHNK PHSEELPTLV
     STIQQDADWD SVLSSQQRME SENNKLCSLY SFRNTSTSPH KPDEGSRDRE IMTSVTFGTP
     ERRKGSLADV VDTLKQKKLE EMTRTEQEDS SCMEKLLSK
//