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Protein
Submitted name:

Sortilin-related receptor

Gene

SORL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Sortilin-related receptorImported
Gene namesi
Name:SORL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11185. SORL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1080 – 1103HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137642.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiE9PPB3.
PaxDbiE9PPB3.
PeptideAtlasiE9PPB3.
PRIDEiE9PPB3.

Expressioni

Gene expression databases

BgeeiENSG00000137642.
ExpressionAtlasiE9PPB3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000260197.

Structurei

3D structure databases

ProteinModelPortaliE9PPB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini501 – 593Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini597 – 689Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini693 – 788Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini878 – 973Fibronectin type-IIIInterPro annotationAdd BLAST96

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
KOG3511. Eukaryota.
ENOG410Y3W5. LUCA.
GeneTreeiENSGT00760000118968.

Family and domain databases

CDDicd00063. FN3. 5 hits.
Gene3Di2.60.40.10. 5 hits.
4.10.400.10. 10 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00057. Ldl_recept_a. 10 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00060. FN3. 6 hits.
SM00192. LDLa. 11 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
SSF57424. SSF57424. 11 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01209. LDLRA_1. 10 hits.
PS50068. LDLRA_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PPB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDCPQGYQL KNNTCVKQEN TCLRNQYRCS NGNCINSIWW CDFDNDCGDM
60 70 80 90 100
SDERNCPTTI CDLDTQFRCQ ESGTCIPLSY KCDLEDDCGD NSDESHCEMH
110 120 130 140 150
QCRSDEYNCS SGMCIRSSWV CDGDNDCRDW SDEANCTAIY HTCEASNFQC
160 170 180 190 200
RNGHCIPQRW ACDGDTDCQD GSDEDPVNCE KKCNGFRCPN GTCIPSSKHC
210 220 230 240 250
DGLRDCSDGS DEQHCEPLCT HFMDFVCKNR QQCLFHSMVC DGIIQCRDGS
260 270 280 290 300
DEDAAFAGCS QDPEFHKVCD EFGFQCQNGV CISLIWKCDG MDDCGDYSDE
310 320 330 340 350
ANCENPTEAP NCSRYFQFRC ENGHCIPNRW KCDRENDCGD WSDEKDCGDS
360 370 380 390 400
HILPFSTPGP STCLPNYYRC SSGTCVMDTW VCDGYRDCAD GSDEEACPLL
410 420 430 440 450
ANVTAASTPT QLGRCDRFEF ECHQPKTCIP NWKRCDGHQD CQDGRDEANC
460 470 480 490 500
PTHSTLTCMS REFQCEDGEA CIVLSERCDG FLDCSDESDE KACSDELTVY
510 520 530 540 550
KVQNLQWTAD FSGDVTLTWM RPKKMPSASC VYNVYYRVVG ESIWKTLETH
560 570 580 590 600
SNKTNTVLKV LKPDTTYQVK VQVQCLSKAH NTNDFVTLRT PEGLPDAPRN
610 620 630 640 650
LQLSLPREAE GVIVGHWAPP IHTHGLIREY IVEYSRSGSK MWASQRAASN
660 670 680 690 700
FTEIKNLLVN TLYTVRVAAV TSRGIGNWSD SKSITTIKGK VIPPPDIHID
710 720 730 740 750
SYGENYLSFT LTMESDIKVN GYVVNLFWAF DTHKQERRTL NFRGSILSHK
760 770 780 790 800
VGNLTAHTSY EISAWAKTDL GDSPLAFEHV MTRGVRPPAP SLKAKAINQT
810 820 830 840 850
AVECTWTGPR NVVYGIFYAT SFLDLYRNPK SLTTSLHNKT VIVSKDEQYL
860 870 880 890 900
FLVRVVVPYQ GPSSDYVVVK MIPDSRLPPR HLHVVHTGKT SVVIKWESPY
910 920 930 940 950
DSPDQDLLYA VAVKDLIRKT DRSYKVKSRN STVEYTLNKL EPGGKYHIIV
960 970 980 990 1000
QLGNMSKDSS IKITTVSLSA PDALKIITEN DHVLLFWKSL ALKEKHFNES
1010 1020 1030 1040 1050
RGYEIHMFDS AMNITAYLGN TTDNFFKISN LKMGHNYTFT VQARCLFGNQ
1060 1070 1080 1090 1100
ICGEPAILLY DELGSGADAS ATQAARSTDV AAVVVPILFL ILLSLGVGFA
1110 1120 1130 1140 1150
ILYTKHRRLQ SSFTAFANSH YSSRLGSAIF SSGDDLGEDD EDAPMITGFS

DDVPMVIA
Length:1,158
Mass (Da):129,705
Last modified:April 5, 2011 - v1
Checksum:i2C4720A07C9D4C9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000664 Genomic DNA. No translation available.
AP000977 Genomic DNA. No translation available.
KF459541 Genomic DNA. No translation available.
RefSeqiXP_011541269.1. XM_011542967.2.
UniGeneiHs.368592.

Genome annotation databases

EnsembliENST00000525532; ENSP00000434634; ENSG00000137642.
GeneIDi6653.
UCSCiuc058ina.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000664 Genomic DNA. No translation available.
AP000977 Genomic DNA. No translation available.
KF459541 Genomic DNA. No translation available.
RefSeqiXP_011541269.1. XM_011542967.2.
UniGeneiHs.368592.

3D structure databases

ProteinModelPortaliE9PPB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000260197.

Proteomic databases

MaxQBiE9PPB3.
PaxDbiE9PPB3.
PeptideAtlasiE9PPB3.
PRIDEiE9PPB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000525532; ENSP00000434634; ENSG00000137642.
GeneIDi6653.
UCSCiuc058ina.1. human.

Organism-specific databases

CTDi6653.
HGNCiHGNC:11185. SORL1.
OpenTargetsiENSG00000137642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
KOG3511. Eukaryota.
ENOG410Y3W5. LUCA.
GeneTreeiENSGT00760000118968.

Miscellaneous databases

ChiTaRSiSORL1. human.
GenomeRNAii6653.

Gene expression databases

BgeeiENSG00000137642.
ExpressionAtlasiE9PPB3. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 5 hits.
Gene3Di2.60.40.10. 5 hits.
4.10.400.10. 10 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00057. Ldl_recept_a. 10 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00060. FN3. 6 hits.
SM00192. LDLa. 11 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
SSF57424. SSF57424. 11 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01209. LDLRA_1. 10 hits.
PS50068. LDLRA_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PPB3_HUMAN
AccessioniPrimary (citable) accession number: E9PPB3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.