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Protein
Submitted name:

Sortilin-related receptor

Gene

SORL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Sortilin-related receptorImported
Gene namesi
Name:SORL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137642.12
HGNCiHGNC:11185 SORL1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1080 – 1103HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137642

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 34PROSITE-ProRule annotation
Disulfide bondi29 ↔ 47PROSITE-ProRule annotation
Disulfide bondi41 ↔ 56PROSITE-ProRule annotation
Disulfide bondi82 ↔ 97PROSITE-ProRule annotation
Disulfide bondi102 ↔ 114PROSITE-ProRule annotation
Disulfide bondi109 ↔ 127PROSITE-ProRule annotation
Disulfide bondi121 ↔ 136PROSITE-ProRule annotation
Disulfide bondi143 ↔ 155PROSITE-ProRule annotation
Disulfide bondi150 ↔ 168PROSITE-ProRule annotation
Disulfide bondi188 ↔ 206PROSITE-ProRule annotation
Disulfide bondi200 ↔ 215PROSITE-ProRule annotation
Disulfide bondi269 ↔ 281PROSITE-ProRule annotation
Disulfide bondi276 ↔ 294PROSITE-ProRule annotation
Disulfide bondi288 ↔ 303PROSITE-ProRule annotation
Disulfide bondi320 ↔ 338PROSITE-ProRule annotation
Disulfide bondi332 ↔ 347PROSITE-ProRule annotation
Disulfide bondi363 ↔ 375PROSITE-ProRule annotation
Disulfide bondi370 ↔ 388PROSITE-ProRule annotation
Disulfide bondi382 ↔ 397PROSITE-ProRule annotation
Disulfide bondi435 ↔ 450PROSITE-ProRule annotation
Disulfide bondi478 ↔ 493PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

EPDiE9PPB3
MaxQBiE9PPB3
PeptideAtlasiE9PPB3
PRIDEiE9PPB3

Expressioni

Gene expression databases

BgeeiENSG00000137642
ExpressionAtlasiE9PPB3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PPB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini501 – 593Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini597 – 689Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini693 – 788Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini878 – 973Fibronectin type-IIIInterPro annotationAdd BLAST96

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1215 Eukaryota
KOG3511 Eukaryota
ENOG410Y3W5 LUCA
GeneTreeiENSGT00510000046443

Family and domain databases

CDDicd00063 FN3, 5 hits
cd00112 LDLa, 11 hits
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF00057 Ldl_recept_a, 10 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00192 LDLa, 11 hits
SUPFAMiSSF49265 SSF49265, 3 hits
SSF57424 SSF57424, 11 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS01209 LDLRA_1, 5 hits
PS50068 LDLRA_2, 11 hits

Sequencei

Sequence statusi: Complete.

E9PPB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDCPQGYQL KNNTCVKQEN TCLRNQYRCS NGNCINSIWW CDFDNDCGDM
60 70 80 90 100
SDERNCPTTI CDLDTQFRCQ ESGTCIPLSY KCDLEDDCGD NSDESHCEMH
110 120 130 140 150
QCRSDEYNCS SGMCIRSSWV CDGDNDCRDW SDEANCTAIY HTCEASNFQC
160 170 180 190 200
RNGHCIPQRW ACDGDTDCQD GSDEDPVNCE KKCNGFRCPN GTCIPSSKHC
210 220 230 240 250
DGLRDCSDGS DEQHCEPLCT HFMDFVCKNR QQCLFHSMVC DGIIQCRDGS
260 270 280 290 300
DEDAAFAGCS QDPEFHKVCD EFGFQCQNGV CISLIWKCDG MDDCGDYSDE
310 320 330 340 350
ANCENPTEAP NCSRYFQFRC ENGHCIPNRW KCDRENDCGD WSDEKDCGDS
360 370 380 390 400
HILPFSTPGP STCLPNYYRC SSGTCVMDTW VCDGYRDCAD GSDEEACPLL
410 420 430 440 450
ANVTAASTPT QLGRCDRFEF ECHQPKTCIP NWKRCDGHQD CQDGRDEANC
460 470 480 490 500
PTHSTLTCMS REFQCEDGEA CIVLSERCDG FLDCSDESDE KACSDELTVY
510 520 530 540 550
KVQNLQWTAD FSGDVTLTWM RPKKMPSASC VYNVYYRVVG ESIWKTLETH
560 570 580 590 600
SNKTNTVLKV LKPDTTYQVK VQVQCLSKAH NTNDFVTLRT PEGLPDAPRN
610 620 630 640 650
LQLSLPREAE GVIVGHWAPP IHTHGLIREY IVEYSRSGSK MWASQRAASN
660 670 680 690 700
FTEIKNLLVN TLYTVRVAAV TSRGIGNWSD SKSITTIKGK VIPPPDIHID
710 720 730 740 750
SYGENYLSFT LTMESDIKVN GYVVNLFWAF DTHKQERRTL NFRGSILSHK
760 770 780 790 800
VGNLTAHTSY EISAWAKTDL GDSPLAFEHV MTRGVRPPAP SLKAKAINQT
810 820 830 840 850
AVECTWTGPR NVVYGIFYAT SFLDLYRNPK SLTTSLHNKT VIVSKDEQYL
860 870 880 890 900
FLVRVVVPYQ GPSSDYVVVK MIPDSRLPPR HLHVVHTGKT SVVIKWESPY
910 920 930 940 950
DSPDQDLLYA VAVKDLIRKT DRSYKVKSRN STVEYTLNKL EPGGKYHIIV
960 970 980 990 1000
QLGNMSKDSS IKITTVSLSA PDALKIITEN DHVLLFWKSL ALKEKHFNES
1010 1020 1030 1040 1050
RGYEIHMFDS AMNITAYLGN TTDNFFKISN LKMGHNYTFT VQARCLFGNQ
1060 1070 1080 1090 1100
ICGEPAILLY DELGSGADAS ATQAARSTDV AAVVVPILFL ILLSLGVGFA
1110 1120 1130 1140 1150
ILYTKHRRLQ SSFTAFANSH YSSRLGSAIF SSGDDLGEDD EDAPMITGFS

DDVPMVIA
Length:1,158
Mass (Da):129,705
Last modified:April 5, 2011 - v1
Checksum:i2C4720A07C9D4C9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000664 Genomic DNA No translation available.
AP000977 Genomic DNA No translation available.
KF459541 Genomic DNA No translation available.
RefSeqiXP_011541269.1, XM_011542967.2
UniGeneiHs.368592

Genome annotation databases

EnsembliENST00000525532; ENSP00000434634; ENSG00000137642
GeneIDi6653
UCSCiuc058ina.1 human

Similar proteinsi

Entry informationi

Entry nameiE9PPB3_HUMAN
AccessioniPrimary (citable) accession number: E9PPB3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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