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Protein

V-type proton ATPase subunit a

Gene

TCIRG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:TCIRG1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11647. TCIRG1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiE9PNA6.
PeptideAtlasiE9PNA6.

Expressioni

Gene expression databases

BgeeiE9PNA6.
ExpressionAtlasiE9PNA6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265686.

Structurei

3D structure databases

ProteinModelPortaliE9PNA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili233 – 26331Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
GeneTreeiENSGT00390000004941.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PNA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSMFRSEEV ALVQLFLPTA AAYTCLNASV SAFQRRFVVD VRRCEELEKT
60 70 80 90 100
FTFLQEEVRR AGLVLPPPKG RLPAPPPRDL LRIQEETERL AQELRDVRGN
110 120 130 140 150
QQALRAQLHQ LQLHAAVLRQ GHEPQLAAAH TDGASERTPL LQAPGGPHQD
160 170 180 190 200
LRVNFVAGAV EPHKAPALER LLWRACRGFL IASFRELEQP LEHPVTGEPA
210 220 230 240 250
TWMTFLISYW GEQIGQKIRK ITDCFHCHVF PFLQQEEARL GALQQLQQQS
260 270 280 290
QELQEVLGET ERFLSQVLGR VLQLLPPGQV QVHKMKAVYL ALNQCSVST
Length:299
Mass (Da):33,778
Last modified:April 5, 2011 - v1
Checksum:i5825169E58AF2704
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei299 – 2991Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002807 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000524598; ENSP00000432846; ENSG00000110719.
UCSCiuc058elk.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002807 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PNA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265686.

Proteomic databases

PaxDbiE9PNA6.
PeptideAtlasiE9PNA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000524598; ENSP00000432846; ENSG00000110719.
UCSCiuc058elk.1. human.

Organism-specific databases

HGNCiHGNC:11647. TCIRG1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
GeneTreeiENSGT00390000004941.

Miscellaneous databases

ChiTaRSiTCIRG1. human.

Gene expression databases

BgeeiE9PNA6.
ExpressionAtlasiE9PNA6. baseline and differential.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PNA6_HUMAN
AccessioniPrimary (citable) accession number: E9PNA6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.