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Protein

V-type proton ATPase subunit a

Gene

TCIRG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:TCIRG1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110719.9
HGNCiHGNC:11647 TCIRG1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110719

PTM / Processingi

Proteomic databases

MaxQBiE9PMC5
PeptideAtlasiE9PMC5
PRIDEiE9PMC5

Expressioni

Gene expression databases

BgeeiENSG00000110719
ExpressionAtlasiE9PMC5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PMC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 114Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2189 Eukaryota
COG1269 LUCA
GeneTreeiENSGT00390000004941

Family and domain databases

InterProiView protein in InterPro
IPR002490 V-ATPase_116kDa_su
PANTHERiPTHR11629 PTHR11629, 1 hit
PfamiView protein in Pfam
PF01496 V_ATPase_I, 1 hit

Sequencei

Sequence statusi: Complete.

E9PMC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSMFRSEEV ALVQLFLPTA AAYTCVSRLG ELGLVEFRDL NASVSAFQRR
60 70 80 90 100
FVVDVRRCEE LEKTFTFLQE EVRRAGLVLP PPKGRLPAPP PRDLLRIQEE
110 120 130 140 150
TERLAQELRD VRGNQQALRA QLHQLQLHAA VLRQGHEPQL AAAHTDGASE
160 170
RTPLLQAPGG PHQDLRVKAS QPRG
Length:174
Mass (Da):19,440
Last modified:April 5, 2011 - v1
Checksum:i058367B0C8D7BCC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002807 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000534673; ENSP00000431174; ENSG00000110719
UCSCiuc058elj.1 human

Similar proteinsi

Entry informationi

Entry nameiE9PMC5_HUMAN
AccessioniPrimary (citable) accession number: E9PMC5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health