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Protein
Submitted name:

Apoptosis-inducing factor 1, mitochondrial

Gene

AIFM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Apoptosis-inducing factor 1, mitochondrialImported
Gene namesi
Name:AIFM1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000156709.13
HGNCiHGNC:8768 AIFM1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156709

PTM / Processingi

Proteomic databases

EPDiE9PMA0
MaxQBiE9PMA0
PeptideAtlasiE9PMA0
PRIDEiE9PMA0

Expressioni

Gene expression databases

BgeeiENSG00000156709
ExpressionAtlasiE9PMA0 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9PMA0
SMRiE9PMA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 121FAD/NAD-binding_domInterPro annotationAdd BLAST117
Domaini126 – 255AIF_CInterPro annotationAdd BLAST130

Phylogenomic databases

eggNOGiKOG1346 Eukaryota
COG0446 LUCA
GeneTreeiENSGT00530000063416

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR029324 AIF_C
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
PfamiView protein in Pfam
PF14721 AIF_C, 1 hit
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit

Sequencei

Sequence statusi: Complete.

E9PMA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKILPEYLS NWTMEKVRRE GVKVMPNAIV QSVGVSSGKL LIKLKDGRKV
60 70 80 90 100
ETDHIVAAVG LEPNVELAKT GGLEIDSDFG GFRVNAELQA RSNIWVAGDA
110 120 130 140 150
ACFYDIKLGR RRVEHHDHAV VSGRLAGENM TGAAKPYWHQ SMFWSDLGPD
160 170 180 190 200
VGYEAIGLVD SSLPTVGVFA KATAQDNPKS ATEQSGTGIR SESETESEAS
210 220 230 240 250
EITIPPSTPA VPQAPVQGED YGKGVIFYLR DKVVVGIVLW NIFNRMPIAR
260 270
KIIKDGEQHE DLNEVAKLFN IHED
Length:274
Mass (Da):29,938
Last modified:April 5, 2011 - v1
Checksum:i0BFD7337C48478BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139234 Genomic DNA No translation available.
KF459397 Genomic DNA No translation available.
KF510638 Genomic DNA No translation available.
RefSeqiNP_001124318.2, NM_001130846.3
UniGeneiHs.424932

Genome annotation databases

EnsembliENST00000460436; ENSP00000431222; ENSG00000156709
GeneIDi9131
UCSCiuc011mur.3 human

Similar proteinsi

Entry informationi

Entry nameiE9PMA0_HUMAN
AccessioniPrimary (citable) accession number: E9PMA0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health