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E9PM46 (E9PM46_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length1355 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). RuleBase RU004435

Sequence similarities

Belongs to the peptidase C19 family.

Contains USP domain. SAAS SAAS001394

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000433146

Sequences

Sequence LengthMass (Da)Tools
E9PM46 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 1AE6E4E9054F921A

FASTA1,355154,697
        10         20         30         40         50         60 
MVPGEENQLV PKEIENAAEE PRVLCIIQDT TNSKTVNERI TLNLPASTPV RKLFEDVANK 

        70         80         90        100        110        120 
VGYINGTFDL VWGNGINTAD MAPLDHTSDK SLLDANFEPG KKNFLHLTDK DGEQPQILLE 

       130        140        150        160        170        180 
DSSAGEDSVH DRFIGPLPRE GSGGSTSDYV SQSYSYSSIL NKSETGYVGL VNQAMTCYLN 

       190        200        210        220        230        240 
SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF VLLQTSKKRA IETTDVTRSF 

       250        260        270        280        290        300 
GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL YQGKLKDYVR CLECGYEGWR 

       310        320        330        340        350        360 
IDTYLDIPLV IRPYGSSQAF ASVEEALHAF IQPEILDGPN QYFCERCKKK CDARKGLRFL 

       370        380        390        400        410        420 
HFPYLLTLQL KRFDFDYTTM HRIKLNDRMT FPEELDMSTF IDVEDEKSPQ TESCTDSGAE 

       430        440        450        460        470        480 
NEGSCHSDQM SNDFSNDDGV DEGICLETNS GTEKISKSGL EKNSLIYELF SVMVHSGSAA 

       490        500        510        520        530        540 
GGHYYACIKS FSDEQWYSFN DQHVSRITQE DIKKTHGGSS GSRGYYSSAF ASSTNAYMLI 

       550        560        570        580        590        600 
YRLKDPARNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR EIERNTCKIK LFCLHPTKQV 

       610        620        630        640        650        660 
MMENKLEVHK DKTLKEAVEM AYKMMDLEEV IPLDCCRLVK YDEFHDYLER SYEGEEDTPM 

       670        680        690        700        710        720 
GLLLGGVKST YMFDLLLETR KPDQVFQSYK PGEVMVKVHV VDLKAESVAA PITVRAYLNQ 

       730        740        750        760        770        780 
TVTEFKQLIS KAIHLPAETM RIVLERCYND LRLLSVSSKT LKAEGFFRSN KVFVESSETL 

       790        800        810        820        830        840 
DYQMAFADSH LWKLLDRHAN TIRLFVLLPE QSPVSYSKRT AYQKAGGDSG NVDDDCERVK 

       850        860        870        880        890        900 
GPVGSLKSVE AILEESTEKL KSLSLQQQQD GDNGDSSKST ETSDFENIES PLNERDSSAS 

       910        920        930        940        950        960 
VDNRELEQHI QTSDPENFQS EERSDSDVNN DRSTSSVDSD ILSSSHSSDT LCNADNAQIP 

       970        980        990       1000       1010       1020 
LANGLDSHSI TSSRRTKANE GKKETWDTAE EDSGTDSEYD ESGKSRGEMQ YMYFKAEPYA 

      1030       1040       1050       1060       1070       1080 
ADEGSGEGHK WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF KVFRVYASNQ EFESVRLNET 

      1090       1100       1110       1120       1130       1140 
LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEQEPCKF LLDAVFAKGM TVRQSKEELI 

      1150       1160       1170       1180       1190       1200 
PQLREQCGLE LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI NISSNWEVFL EVLDGVEKMK 

      1210       1220       1230       1240       1250       1260 
SMSQLAVLSR RWKPSEMKLD PFQEVVLESS SVDELREKLS EISGIPLDDI EFAKGRGTFP 

      1270       1280       1290       1300       1310       1320 
CDISVLDIHQ DLDWNPKVST LNVWPLYICD DGAVIFYRDK TEELMELTDE QRNELMKKES 

      1330       1340       1350 
SRLQKTGHRV TYSPRKEKAL KIYLDGAPNK DLTQD 

« Hide

References

« Hide 'large scale' references
[1]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC104383 Genomic DNA. No translation available.
AC124276 Genomic DNA. No translation available.
RefSeqNP_001269588.1. NM_001282659.1.
UniGeneHs.577256.

3D structure databases

ProteinModelPortalE9PM46.
SMRE9PM46. Positions 162-576.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

MaxQBE9PM46.
PRIDEE9PM46.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000527733; ENSP00000433146; ENSG00000170242.
GeneID55031.
KEGGhsa:55031.
UCSCuc001mjs.3. human.

Organism-specific databases

CTD55031.
HGNCHGNC:20076. USP47.
GenAtlasSearch...

Phylogenomic databases

KOK11857.

Gene expression databases

ArrayExpressE9PM46.
BgeeE9PM46.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF14560. Ubiquitin_2. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SUPFAMSSF54236. SSF54236. 1 hit.
PROSITEPS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSUSP47. human.
NextBio35503418.

Entry information

Entry nameE9PM46_HUMAN
AccessionPrimary (citable) accession number: E9PM46
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.