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Protein

V-type proton ATPase subunit a

Gene

TCIRG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:TCIRG1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11647. TCIRG1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110719.

PTM / Processingi

Proteomic databases

PaxDbiE9PM12.
PeptideAtlasiE9PM12.
PRIDEiE9PM12.

Expressioni

Gene expression databases

BgeeiENSG00000110719.
ExpressionAtlasiE9PM12. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265686.

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
GeneTreeiENSGT00390000004941.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PM12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSMFRSEEV ALVQLFLPTA AAYTCVSRLG ELGLVEFRDL NASVSAFQRR
60 70 80 90 100
FVVDVRRCEE LEKTFTFLQE EVRRAGLVLP PPKGRLPAPP PRDLLRIQEE
110 120 130 140 150
TERLAQELRD VRGNQQALRA QLHQLQLHAA VLRQGHEPQL AAAHTDGASE
160 170 180 190 200
RTPLLQAPGG PHQDLRVNFV AGAVEPHKAP ALERLLWRAC RGFLIASFRE
210
LEQPLEHPVT GEPATWM
Length:217
Mass (Da):24,341
Last modified:October 5, 2016 - v8
Checksum:i254F5DECA9870B35
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei217Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002807 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000529657; ENSP00000435023; ENSG00000110719.
UCSCiuc058ell.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002807 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265686.

Proteomic databases

PaxDbiE9PM12.
PeptideAtlasiE9PM12.
PRIDEiE9PM12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000529657; ENSP00000435023; ENSG00000110719.
UCSCiuc058ell.1. human.

Organism-specific databases

HGNCiHGNC:11647. TCIRG1.
OpenTargetsiENSG00000110719.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
GeneTreeiENSGT00390000004941.

Miscellaneous databases

ChiTaRSiTCIRG1. human.

Gene expression databases

BgeeiENSG00000110719.
ExpressionAtlasiE9PM12. baseline and differential.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PM12_HUMAN
AccessioniPrimary (citable) accession number: E9PM12
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 5, 2016
Last modified: November 2, 2016
This is version 41 of the entry and version 8 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.