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Protein
Submitted name:

Neutral alpha-glucosidase AB

Gene

GANAB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Names & Taxonomyi

Protein namesi
Submitted name:
Neutral alpha-glucosidase ABImported
Gene namesi
Name:GANABImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:4138. GANAB.

PTM / Processingi

Proteomic databases

EPDiE9PKU7.
PaxDbiE9PKU7.
PRIDEiE9PKU7.

Expressioni

Gene expression databases

BgeeiE9PKU7.
ExpressionAtlasiE9PKU7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340466.

Structurei

3D structure databases

ProteinModelPortaliE9PKU7.
SMRiE9PKU7. Positions 147-819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini162 – 23271Gal_mutarotas_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1066. Eukaryota.
COG1501. LUCA.
GeneTreeiENSGT00760000119229.
KOiK05546.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR030458. Glyco_hydro_31_AS.
IPR030459. Glyco_hydro_31_CS.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PKU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVAAVAAR RRRLSVSGRD ENSVELTMAE GPYKIILTAR PFRLDLLEDR
60 70 80 90 100
SLLLSVNARG LLEFEHQRAP RVSFSDKVNL TLGSIWDKIK NLFSRQGSKD
110 120 130 140 150
PAEGDGAQPE ETPRDGDKPE ETQGKAEKDE PGAWEETFKT HSDSKPYGPM
160 170 180 190 200
SVGLDFSLPG MEHVYGIPEH ADNLRLKVTE GGEPYRLYNL DVFQYELYNP
210 220 230 240 250
MALYGSVPVL LAHNPHRDLG IFWLNAAETW VDISSNTAGK TLFGKMMDYL
260 270 280 290 300
QGSGETPQTD VRWMSETGII DVFLLLGPSI SDVFRQYASL TGTQALPPLF
310 320 330 340 350
SLGYHQSRWN YRDEADVLEV DQGFDDHNLP CDVIWLDIEH ADGKRYFTWD
360 370 380 390 400
PSRFPQPRTM LERLASKRRK LVAIVDPHIK VDSGYRVHEE LRNLGLYVKT
410 420 430 440 450
RDGSDYEGWC WPGSAGYPDF TNPTMRAWWA NMFSYDNYEG SAPNLFVWND
460 470 480 490 500
MNEPSVFNGP EVTMLKDAQH YGGWEHRDVH NIYGLYVHMA TADGLRQRSG
510 520 530 540 550
GMERPFVLAR AFFAGSQRFG AVWTGDNTAE WDHLKISIPM CLSLGLVGLS
560 570 580 590 600
FCGADVGGFF KNPEPELLVR WYQMGAYQPF FRAHAHLDTG RREPWLLPSQ
610 620 630 640 650
HNDIIRDALG QRYSLLPFWY TLLYQAHREG IPVMRPLWVQ YPQDVTTFNI
660 670 680 690 700
DDQYLLGDAL LVHPVSDSGA HGVQVYLPGQ GEVWYDIQSY QKHHGPQTLY
710 720 730 740 750
LPVTLSSIPV FQRGGTIVPR WMRVRRSSEC MKDDPITLFV ALSPQGTAQG
760 770 780 790 800
ELFLDDGHTF NYQTRQEFLL RRFSFSGNTL VSSSADPEGH FETPIWIERV
810 820 830 840 850
VIIGAGKPAA VVLQTKGSPE SRLSFQHDPE TSVLVLRKPG INVASDWSIH

LR
Length:852
Mass (Da):96,544
Last modified:April 5, 2011 - v1
Checksum:iD4E65914B91010E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001458 Genomic DNA. No translation available.
RefSeqiNP_001265121.1. NM_001278192.1.
UniGeneiHs.595071.

Genome annotation databases

EnsembliENST00000534779; ENSP00000435306; ENSG00000089597.
GeneIDi23193.
KEGGihsa:23193.
UCSCiuc010rma.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001458 Genomic DNA. No translation available.
RefSeqiNP_001265121.1. NM_001278192.1.
UniGeneiHs.595071.

3D structure databases

ProteinModelPortaliE9PKU7.
SMRiE9PKU7. Positions 147-819.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340466.

Proteomic databases

EPDiE9PKU7.
PaxDbiE9PKU7.
PRIDEiE9PKU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000534779; ENSP00000435306; ENSG00000089597.
GeneIDi23193.
KEGGihsa:23193.
UCSCiuc010rma.4. human.

Organism-specific databases

CTDi23193.
HGNCiHGNC:4138. GANAB.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1066. Eukaryota.
COG1501. LUCA.
GeneTreeiENSGT00760000119229.
KOiK05546.

Miscellaneous databases

ChiTaRSiGANAB. human.
GenomeRNAii23193.

Gene expression databases

BgeeiE9PKU7.
ExpressionAtlasiE9PKU7. baseline and differential.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR030458. Glyco_hydro_31_AS.
IPR030459. Glyco_hydro_31_CS.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "N-terminome analysis of the human mitochondrial proteome."
    Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.
    Proteomics 15:2519-2524(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE9PKU7_HUMAN
AccessioniPrimary (citable) accession number: E9PKU7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.