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E9PKQ3

- E9PKQ3_HUMAN

UniProt

E9PKQ3 - E9PKQ3_HUMAN

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Protein
Submitted name: Serine/threonine-protein kinase Chk1
Gene
CHEK1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histone kinase activity (H3-T11 specific) Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. DNA damage checkpoint Source: Ensembl
  2. DNA damage induced protein phosphorylation Source: Ensembl
  3. DNA repair Source: Ensembl
  4. G2/M transition of mitotic cell cycle Source: Ensembl
  5. cellular response to caffeine Source: Ensembl
  6. chromatin-mediated maintenance of transcription Source: Ensembl
  7. regulation of cell proliferation Source: Ensembl
  8. regulation of histone H3-K9 acetylation Source: Ensembl
  9. regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiE9PKQ3.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase Chk1Imported
Gene namesi
Name:CHEK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1925. CHEK1.

Subcellular locationi

GO - Cellular componenti

  1. chromatin Source: Ensembl
  2. nucleus Source: Ensembl
  3. replication fork Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiE9PKQ3.
BgeeiE9PKQ3.

Structurei

3D structure databases

ProteinModelPortaliE9PKQ3.
SMRiE9PKQ3. Positions 3-204.

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PKQ3-1 [UniParc]FASTAAdd to Basket

« Hide

MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE    50
NIKKEICINK MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI 100
GMPEPDAQRF FHQLMAGVVY LHGIGITHRD IKPENLLLDE RDNLKISDFG 150
LATVFRYNNR ERLLNKMCGT LPYVAPELLK RREFHAEPVD VWSCGIVLTA 200
MLAG 204
Length:204
Mass (Da):23,296
Last modified:April 5, 2011 - v1
Checksum:i01DB751003708DDA
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei204 – 2041Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001132 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000527013; ENSP00000431525; ENSG00000149554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001132 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9PKQ3.
SMRi E9PKQ3. Positions 3-204.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000527013 ; ENSP00000431525 ; ENSG00000149554 .

Organism-specific databases

HGNCi HGNC:1925. CHEK1.
GenAtlasi Search...

Enzyme and pathway databases

SignaLinki E9PKQ3.

Miscellaneous databases

ChiTaRSi CHEK1. human.
NextBioi 35502980.

Gene expression databases

ArrayExpressi E9PKQ3.
Bgeei E9PKQ3.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PKQ3_HUMAN
AccessioniPrimary (citable) accession number: E9PKQ3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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