E9PKQ3 (E9PKQ3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Serine/threonine-protein kinase Chk1 Ensembl ENSP00000431525

Gene names

Name:

CHEK1 Ensembl ENSP00000431525

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000431525

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	204 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the protein kinase superfamily. RuleBase RU000305
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000431525

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage induced protein phosphorylation Inferred from electronic annotation. Source: Compara DNA repair Inferred from electronic annotation. Source: Compara G2 DNA damage checkpoint Inferred from electronic annotation. Source: Compara G2/M transition of mitotic cell cycle Inferred from electronic annotation. Source: Compara cellular response to caffeine Inferred from electronic annotation. Source: Compara chromatin-mediated maintenance of transcription Inferred from electronic annotation. Source: Compara histone H3-T11 phosphorylation Inferred from electronic annotation. Source: GOC regulation of S phase Inferred from electronic annotation. Source: Compara regulation of cell proliferation Inferred from electronic annotation. Source: Compara regulation of histone H3-K9 acetylation Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Inferred from electronic annotation. Source: Compara
Cellular_component	chromatin Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara replication fork Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW histone kinase activity (H3-T11 specific) Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	204	1	Ensembl ENSP00000431525

Sequences

	Sequence		Length	Mass (Da)
	E9PKQ3 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 01DB751003708DDA	FASTA	204	23,296
	10 20 30 40 50 60 MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE NIKKEICINK 70 80 90 100 110 120 MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI GMPEPDAQRF FHQLMAGVVY 130 140 150 160 170 180 LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRYNNR ERLLNKMCGT LPYVAPELLK 190 200 RREFHAEPVD VWSCGIVLTA MLAG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP001132 Genomic DNA. No translation available.
IPI	IPI00973081.
3D structure databases
ProteinModelPortal	E9PKQ3.
SMR	E9PKQ3. Positions 3-204.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000527013; ENSP00000431525; ENSG00000149554.
Organism-specific databases
HGNC	HGNC:1925. CHEK1.
GenAtlas	Search...
Enzyme and pathway databases
SignaLink	E9PKQ3.
Gene expression databases
ArrayExpress	E9PKQ3.
Bgee	E9PKQ3.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CHEK1. human.
NextBio	35502980.

Entry information

Entry name

E9PKQ3_HUMAN

Accession

Primary (citable) accession number: E9PKQ3

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 29, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.