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E9PKQ3

- E9PKQ3_HUMAN

UniProt

E9PKQ3 - E9PKQ3_HUMAN

Protein
Submitted name:

Serine/threonine-protein kinase Chk1

Gene

CHEK1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. histone kinase activity (H3-T11 specific) Source: Ensembl

    GO - Biological processi

    1. cellular response to caffeine Source: Ensembl
    2. chromatin-mediated maintenance of transcription Source: Ensembl
    3. DNA damage checkpoint Source: Ensembl
    4. DNA damage induced protein phosphorylation Source: Ensembl
    5. DNA repair Source: Ensembl
    6. G2/M transition of mitotic cell cycle Source: Ensembl
    7. regulation of cell proliferation Source: Ensembl
    8. regulation of histone H3-K9 acetylation Source: Ensembl
    9. regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiE9PKQ3.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Serine/threonine-protein kinase Chk1Imported
    Gene namesi
    Name:CHEK1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:1925. CHEK1.

    Subcellular locationi

    GO - Cellular componenti

    1. chromatin Source: Ensembl
    2. nucleus Source: Ensembl
    3. replication fork Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiE9PKQ3.
    BgeeiE9PKQ3.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PKQ3.
    SMRiE9PKQ3. Positions 3-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.UniRule annotation

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    E9PKQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE    50
    NIKKEICINK MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI 100
    GMPEPDAQRF FHQLMAGVVY LHGIGITHRD IKPENLLLDE RDNLKISDFG 150
    LATVFRYNNR ERLLNKMCGT LPYVAPELLK RREFHAEPVD VWSCGIVLTA 200
    MLAG 204
    Length:204
    Mass (Da):23,296
    Last modified:April 5, 2011 - v1
    Checksum:i01DB751003708DDA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei204 – 2041Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP001132 Genomic DNA. No translation available.
    KF455559 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000527013; ENSP00000431525; ENSG00000149554.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP001132 Genomic DNA. No translation available.
    KF455559 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E9PKQ3.
    SMRi E9PKQ3. Positions 3-204.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000527013 ; ENSP00000431525 ; ENSG00000149554 .

    Organism-specific databases

    HGNCi HGNC:1925. CHEK1.
    GenAtlasi Search...

    Enzyme and pathway databases

    SignaLinki E9PKQ3.

    Miscellaneous databases

    ChiTaRSi CHEK1. human.
    NextBioi 35502980.

    Gene expression databases

    ArrayExpressi E9PKQ3.
    Bgeei E9PKQ3.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE9PKQ3_HUMAN
    AccessioniPrimary (citable) accession number: E9PKQ3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3