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Protein

Tetraspanin

Gene

CD81

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
TetraspaninUniRule annotation
Gene namesi
Name:CD81Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110651.11
HGNCiHGNC:1701 CD81

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 43HelicalUniRule annotationAdd BLAST24
Transmembranei131 – 155HelicalUniRule annotationAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110651

PTM / Processingi

Proteomic databases

MaxQBiE9PJK1
PeptideAtlasiE9PJK1
PRIDEiE9PJK1

Expressioni

Gene expression databases

BgeeiENSG00000110651
ExpressionAtlasiE9PJK1 baseline and differential

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit

Sequencei

Sequence statusi: Complete.

E9PJK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFVGFLGCY GAIQESQCLL GTFFTCLVIL FACEVAAGIW GFVNKDQIAK
60 70 80 90 100
DVKQFYDQAL QQAVVDDDAN NAKAVVKTFH ETLDCCGSST LTALTTSVLK
110 120 130 140 150
NNLCPSGSNI ISNLFKEDCH QKIDDLFSGK LYLIGIAAIV VAVIMIFEMI
160
LSMVLCCGIR NSSVY
Length:165
Mass (Da):17,963
Last modified:April 5, 2011 - v1
Checksum:iAABF8E4548B76329
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124057 Genomic DNA No translation available.
AC129929 Genomic DNA No translation available.
RefSeqiNP_001284578.1, NM_001297649.1
XP_016874087.1, XM_017018598.1
UniGeneiHs.54457

Genome annotation databases

EnsembliENST00000492627; ENSP00000437242; ENSG00000110651
ENST00000526072; ENSP00000431780; ENSG00000110651
GeneIDi975
UCSCiuc057xxn.1 human

Similar proteinsi

Entry informationi

Entry nameiE9PJK1_HUMAN
AccessioniPrimary (citable) accession number: E9PJK1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health