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Protein

Tetraspanin

Gene

CD81

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
TetraspaninUniRule annotation
Gene namesi
Name:CD81Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1701. CD81.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 43HelicalUniRule annotationAdd BLAST24
Transmembranei131 – 155HelicalUniRule annotationAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110651.

PTM / Processingi

Proteomic databases

MaxQBiE9PJK1.

Expressioni

Gene expression databases

BgeeiENSG00000110651.
ExpressionAtlasiE9PJK1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000263645.

Structurei

3D structure databases

ProteinModelPortaliE9PJK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00870000136424.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiView protein in InterPro
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
PfamiView protein in Pfam
PF00335. Tetraspannin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PJK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFVGFLGCY GAIQESQCLL GTFFTCLVIL FACEVAAGIW GFVNKDQIAK
60 70 80 90 100
DVKQFYDQAL QQAVVDDDAN NAKAVVKTFH ETLDCCGSST LTALTTSVLK
110 120 130 140 150
NNLCPSGSNI ISNLFKEDCH QKIDDLFSGK LYLIGIAAIV VAVIMIFEMI
160
LSMVLCCGIR NSSVY
Length:165
Mass (Da):17,963
Last modified:April 5, 2011 - v1
Checksum:iAABF8E4548B76329
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124057 Genomic DNA. No translation available.
AC129929 Genomic DNA. No translation available.
RefSeqiNP_001284578.1. NM_001297649.1.
XP_016874087.1. XM_017018598.1.
UniGeneiHs.54457.

Genome annotation databases

EnsembliENST00000492627; ENSP00000437242; ENSG00000110651.
ENST00000526072; ENSP00000431780; ENSG00000110651.
GeneIDi975.
UCSCiuc057xxn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124057 Genomic DNA. No translation available.
AC129929 Genomic DNA. No translation available.
RefSeqiNP_001284578.1. NM_001297649.1.
XP_016874087.1. XM_017018598.1.
UniGeneiHs.54457.

3D structure databases

ProteinModelPortaliE9PJK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263645.

Proteomic databases

MaxQBiE9PJK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000492627; ENSP00000437242; ENSG00000110651.
ENST00000526072; ENSP00000431780; ENSG00000110651.
GeneIDi975.
UCSCiuc057xxn.1. human.

Organism-specific databases

CTDi975.
HGNCiHGNC:1701. CD81.
OpenTargetsiENSG00000110651.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00870000136424.

Miscellaneous databases

ChiTaRSiCD81. human.
GenomeRNAii975.

Gene expression databases

BgeeiENSG00000110651.
ExpressionAtlasiE9PJK1. baseline and differential.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiView protein in InterPro
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
PfamiView protein in Pfam
PF00335. Tetraspannin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiE9PJK1_HUMAN
AccessioniPrimary (citable) accession number: E9PJK1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 12, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.