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E9PJI4

- E9PJI4_HUMAN

UniProt

E9PJI4 - E9PJI4_HUMAN

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Protein
Submitted name:

Serine/threonine-protein kinase Chk1

Gene

CHEK1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histone kinase activity (H3-T11 specific) Source: Ensembl

GO - Biological processi

  1. cellular response to caffeine Source: Ensembl
  2. chromatin-mediated maintenance of transcription Source: Ensembl
  3. DNA damage checkpoint Source: Ensembl
  4. DNA damage induced protein phosphorylation Source: Ensembl
  5. DNA repair Source: Ensembl
  6. G2/M transition of mitotic cell cycle Source: Ensembl
  7. negative regulation of DNA biosynthetic process Source: Ensembl
  8. negative regulation of G2/M transition of mitotic cell cycle Source: Ensembl
  9. regulation of cell proliferation Source: Ensembl
  10. regulation of histone H3-K9 acetylation Source: Ensembl
  11. regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiE9PJI4.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase Chk1Imported
Gene namesi
Name:CHEK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1925. CHEK1.

Subcellular locationi

GO - Cellular componenti

  1. chromatin Source: Ensembl
  2. nucleus Source: Ensembl
  3. replication fork Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9PJI4.
ExpressionAtlasiE9PJI4. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliE9PJI4.
SMRiE9PJI4. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000111032.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PJI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE
60 70 80 90 100
NIKKEICINK MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI
110 120 130 140 150
GMPEPDAQRF FHQLMAGVVY LHGIGITHRD IKPENLLLDE RDNLKISDFG
160 170
LATVFRYNNR ERLLNKMCGT
Length:170
Mass (Da):19,531
Last modified:April 5, 2011 - v1
Checksum:i5E816AA77265F720
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei170 – 1701Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001132 Genomic DNA. No translation available.
KF455559 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000526937; ENSP00000431815; ENSG00000149554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001132 Genomic DNA. No translation available.
KF455559 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9PJI4.
SMRi E9PJI4. Positions 2-170.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi E9PJI4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000526937 ; ENSP00000431815 ; ENSG00000149554 .

Organism-specific databases

HGNCi HGNC:1925. CHEK1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00730000111032.

Enzyme and pathway databases

SignaLinki E9PJI4.

Miscellaneous databases

ChiTaRSi CHEK1. human.
NextBioi 35502599.

Gene expression databases

Bgeei E9PJI4.
ExpressionAtlasi E9PJI4. baseline and differential.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PJI4_HUMAN
AccessioniPrimary (citable) accession number: E9PJI4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3