E9PIX4 (E9PIX4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Paired box protein Pax-6 Ensembl ENSP00000431961

Gene names

Name:

PAX6 Ensembl ENSP00000431961

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000431961

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity RuleBase RU000682.
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000431961

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU000682
Domain	Homeobox RuleBase RU000682
Ligand	DNA-binding RuleBase RU000682
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	astrocyte differentiation Inferred from electronic annotation. Source: Compara axon guidance Inferred from electronic annotation. Source: Compara cell fate determination Inferred from electronic annotation. Source: Compara cerebral cortex regionalization Inferred from electronic annotation. Source: Compara commitment of neuronal cell to specific neuron type in forebrain Inferred from electronic annotation. Source: Compara dorsal/ventral axis specification Inferred from electronic annotation. Source: Compara embryonic camera-type eye morphogenesis Inferred from electronic annotation. Source: Compara eye photoreceptor cell development Inferred from electronic annotation. Source: Compara forebrain anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara forebrain dorsal/ventral pattern formation Inferred from electronic annotation. Source: Compara forebrain-midbrain boundary formation Inferred from electronic annotation. Source: Compara hindbrain development Inferred from electronic annotation. Source: Compara keratinocyte differentiation Inferred from electronic annotation. Source: Compara lacrimal gland development Inferred from electronic annotation. Source: Compara lens development in camera-type eye Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of neuron differentiation Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara oligodendrocyte cell fate specification Inferred from electronic annotation. Source: Compara pancreatic A cell development Inferred from electronic annotation. Source: Compara pituitary gland development Inferred from electronic annotation. Source: Compara positive regulation of cell fate specification Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of neuroblast proliferation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara protein localization to organelle Inferred from electronic annotation. Source: Compara regulation of cell migration Inferred from electronic annotation. Source: Compara regulation of timing of cell differentiation Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Inferred from electronic annotation. Source: Compara salivary gland morphogenesis Inferred from electronic annotation. Source: Compara signal transduction involved in regulation of gene expression Inferred from electronic annotation. Source: Compara smoothened signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nuclear chromatin Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay. Source: HPA
Molecular_function	AT DNA binding Inferred from electronic annotation. Source: Compara RNA polymerase II core promoter sequence-specific DNA binding Inferred from electronic annotation. Source: Compara double-stranded DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E9PIX4 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 2B5AECC2464BBCE3	FASTA	221	24,949
	10 20 30 40 50 60 MRLQLKRKLQ RNRTSFTQEQ IEALEKEFER THYPDVFARE RLAAKIDLPE ARIQVWFSNR 70 80 90 100 110 120 RAKWRREEKL RNQRRQASNT PSHIPISSSF STSVYQPIPQ PTTPVSSFTS GSMLGRTDTA 130 140 150 160 170 180 LTNTYSALPP MPSFTMANNL PMQPPVPSQT SSYSCMLPTS PSVNGRSYDT YTPPHMQTHM 190 200 210 220 NSQPMGTSGT TSTGLISPGV SVPVQVPGSE PDMSQYWPRL Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z83307 Genomic DNA. No translation available. Z95332 Genomic DNA. No translation available.
IPI	IPI00975481.
3D structure databases
ProteinModelPortal	E9PIX4.
SMR	E9PIX4. Positions 10-77.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000464174; ENSP00000431961; ENSG00000007372.
Organism-specific databases
HGNC	HGNC:8620. PAX6.
GenAtlas	Search...
Gene expression databases
ArrayExpress	E9PIX4.
Bgee	E9PIX4.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35502407.

Entry information

Entry name

E9PIX4_HUMAN

Accession

Primary (citable) accession number: E9PIX4

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	April 3, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.