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E9PIQ1

- E9PIQ1_HUMAN

UniProt

E9PIQ1 - E9PIQ1_HUMAN

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Protein
Submitted name:

Breast cancer type 2 susceptibility protein

Gene
BRCA2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell aging Source: Ensembl
  3. chromosome organization Source: Ensembl
  4. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
  5. double-strand break repair via homologous recombination Source: Ensembl
  6. female gonad development Source: Ensembl
  7. hemopoiesis Source: Ensembl
  8. inner cell mass cell proliferation Source: Ensembl
  9. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  10. male meiosis I Source: Ensembl
  11. oocyte maturation Source: Ensembl
  12. positive regulation of mitotic cell cycle Source: Ensembl
  13. regulation of cytokinesis Source: Ensembl
  14. replication fork protection Source: Ensembl
  15. response to gamma radiation Source: Ensembl
  16. response to UV-C Source: Ensembl
  17. response to X-ray Source: Ensembl
  18. spermatogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Breast cancer type 2 susceptibility proteinImported
Gene namesi
Name:BRCA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:1101. BRCA2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiE9PIQ1.
BgeeiE9PIQ1.

Family & Domainsi

Family and domain databases

InterProiIPR015525. BRCA2.
[Graphical view]
PANTHERiPTHR11289. PTHR11289. 1 hit.

Sequencei

Sequence statusi: Fragment.

E9PIQ1-1 [UniParc]FASTAAdd to Basket

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MDQADDVSCP LLNSCLSESP VVLQCTHVTP QRDKSVVCGS LFHTPKFVKG    50
RQTPKHISES LGAEVDPDMS WSSSLATPPT LSSTVLIVRN EEASETVFPH 100
DTTANVKSYF SNHDESLKKN DRFIASVTDS ENTNQREAAS HGFGKTSGNS 150
FKVNSCKDHI GKSMPNVLED EVYETVVDTS EEDSFSLCFS KCRTKNLQKV 200
RTSKTRKKIF HEANADECEK SKNQVKEKYS FVSEVEPNDT DPLDSNVANQ 250
KPFESGSDKI SKEVVPSLAC EWSQLTLSGL NGAQMEKIPL LHISSCDQNI 300
SEKDLLDTEN KRKKDFLTSE NSLPRISSLP KSEKPLNEET VVNKRDEEQH 350
LESHTDCILA VKQAISGTSP VASSFQGIKK SIFRIRESPK ETFNASFSGH 400
MTDPNFKKET EASESGLEIH TVCSQKEDSL CPNLIDNGSW PATTTQNSVA 450
LKNAGLISTL KKKTNKFIYA IHDETSYKGK K 481
Length:481
Mass (Da):53,300
Last modified:June 26, 2013 - v2
Checksum:i028355CC96460AE8
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei481 – 4811Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL137247 Genomic DNA. No translation available.
AL445212 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000530893; ENSP00000435699; ENSG00000139618.
UCSCiuc001uua.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL137247 Genomic DNA. No translation available.
AL445212 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000530893 ; ENSP00000435699 ; ENSG00000139618 .
UCSCi uc001uua.1. human.

Organism-specific databases

HGNCi HGNC:1101. BRCA2.
GenAtlasi Search...

Miscellaneous databases

NextBioi 35502340.

Gene expression databases

ArrayExpressi E9PIQ1.
Bgeei E9PIQ1.

Family and domain databases

InterProi IPR015525. BRCA2.
[Graphical view ]
PANTHERi PTHR11289. PTHR11289. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PIQ1_HUMAN
AccessioniPrimary (citable) accession number: E9PIQ1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: June 26, 2013
Last modified: July 9, 2014
This is version 19 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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