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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 11

Gene

MAP3K11

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. JUN kinase kinase kinase activity Source: Ensembl

GO - Biological processi

  1. cell death Source: Ensembl
  2. positive regulation of neuron apoptotic process Source: Ensembl
  3. protein autophosphorylation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 11Imported
Gene namesi
Name:MAP3K11Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:6850. MAP3K11.

Expressioni

Gene expression databases

BgeeiE9PID4.
ExpressionAtlasiE9PID4. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliE9PID4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118807.

Sequencei

Sequence statusi: Complete.

E9PID4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEATWYLDS DDSSPLGSPS TPPALNGNPP RPSLEPEEPK RPVPAERGSS
60 70 80 90 100
SGTPKLIQRA LLRGTALLAS LGLGRDLQPP GGPGRERGES PTTPPTPTPA
110 120 130 140 150
PCPTEPPPSP LICFSLKTPD SPPTPAPLLL DLGIPVGQRS AKSPRREEEP
160 170 180 190 200
RGGTVSPPPG TSRSAPGTPG TPRSPPLGLI SRPRPSPLRS RIDPWSFVSA
210 220 230 240 250
GPRPSPLPSP QPAPRRAPWT LFPDSDPFWD SPPANPFQGG PQDCRAQTKD
260
MGAQAPWVPE AGP
Length:263
Mass (Da):27,585
Last modified:April 5, 2011 - v1
Checksum:i03486BE4D6F197F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001362 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000532507; ENSP00000432068; ENSG00000173327.
UCSCiuc001oev.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001362 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PID4.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiE9PID4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532507; ENSP00000432068; ENSG00000173327.
UCSCiuc001oev.3. human.

Organism-specific databases

HGNCiHGNC:6850. MAP3K11.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118807.

Miscellaneous databases

NextBioi35502236.

Gene expression databases

BgeeiE9PID4.
ExpressionAtlasiE9PID4. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:ra46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE9PID4_HUMAN
AccessioniPrimary (citable) accession number: E9PID4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 1, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationMaxQB annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.