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E9PHY1 (E9PHY1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:LRP5 Ensembl ENSP00000436652
OrganismHomo sapiens (Human) [Reference proteome] Ensembl ENSP00000436652
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000436652

Ontologies

Keywords
   Cellular componentMembrane
   DomainEGF-like domain SAAS SAAS011042
Repeat SAAS SAAS011042
Transmembrane
Transmembrane helix SAAS SAAS000033
   PTMDisulfide bond SAAS SAAS011042
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanatomical structure regression

Inferred from electronic annotation. Source: Ensembl

anterior/posterior pattern specification

Inferred from electronic annotation. Source: Ensembl

apoptotic process involved in patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

bone development

Inferred from electronic annotation. Source: Ensembl

bone remodeling

Inferred from electronic annotation. Source: Ensembl

branching involved in mammary gland duct morphogenesis

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

cell migration involved in gastrulation

Inferred from electronic annotation. Source: Ensembl

cell-cell signaling involved in mammary gland development

Inferred from electronic annotation. Source: Ensembl

cholesterol metabolic process

Inferred from electronic annotation. Source: Ensembl

embryonic digit morphogenesis

Inferred from electronic annotation. Source: Ensembl

extracellular matrix-cell signaling

Inferred from electronic annotation. Source: Ensembl

gastrulation with mouth forming second

Inferred from electronic annotation. Source: Ensembl

osteoblast development

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

regulation of bone remodeling

Inferred from electronic annotation. Source: Ensembl

regulation of insulin secretion involved in cellular response to glucose stimulus

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

retina vasculature morphogenesis in camera-type eye

Inferred from electronic annotation. Source: Ensembl

somatic stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrion

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionWnt-activated receptor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
E9PHY1 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 9457467F2F09FCC9

FASTA47152,432
        10         20         30         40         50         60 
MEAAPPGPPW PLLLLLLLLL ALCGCPAPAA ASPLLLFANR RDVRLVDAGG VKLESTIVVS 

        70         80         90        100        110        120 
GLEDAAAVDF QFSKGAVYWT DVSEEAIKQT YLNQTGAAVQ NVVISGLVSP DGLACDWVGK 

       130        140        150        160        170        180 
KLYWTDSETN RIEVANLNGT SRKVLFWQDL DQPRAIALDP AHGYMYWTDW GETPRIERAG 

       190        200        210        220        230        240 
MDGSTRKIIV DSDIYWPNGL TIDLEEQKLY WADAKLSFIH RANLDGSFRQ KVVEGSLTHP 

       250        260        270        280        290        300 
FALTLSGDTL YWTDWQTRSI HACNKRTGGK RKEILSALYS PMDIQVLSQE RQPFFHTRCE 

       310        320        330        340        350        360 
EDNGGCSHLC LLSPSEPFYT CACPTGVQLQ DNGRTCKAGA EEVLLLARRT DLRRISLDTP 

       370        380        390        400        410        420 
DFTDIVLQVD DIRHAIAIDY DPLEGYVYWT DDEVRAIRRA YLDGSGAQTL VNTEINDPDG 

       430        440        450        460        470 
IAVDWVARNL YWTDTGTDRI EVTRLNGTSR KILVSEDLDE PRAIALHPVM G 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP000807 Genomic DNA. No translation available.
AP002813 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalE9PHY1.
SMRE9PHY1. Positions 32-471.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000529993; ENSP00000436652; ENSG00000162337.

Organism-specific databases

HGNCHGNC:6697. LRP5.
GenAtlasSearch...

Gene expression databases

ArrayExpressE9PHY1.
BgeeE9PHY1.

Family and domain databases

Gene3D2.120.10.30. 2 hits.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamPF00058. Ldl_recept_b. 5 hits.
[Graphical view]
SMARTSM00181. EGF. 1 hit.
SM00135. LY. 7 hits.
[Graphical view]
PROSITEPS51120. LDLRB. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio35502095.

Entry information

Entry nameE9PHY1_HUMAN
AccessionPrimary (citable) accession number: E9PHY1
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.