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E9PHY1

- E9PHY1_HUMAN

UniProt

E9PHY1 - E9PHY1_HUMAN

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Protein
Submitted name:

Low-density lipoprotein receptor-related protein 5

Gene

LRP5

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. Wnt-activated receptor activity Source: Ensembl

GO - Biological processi

  1. anatomical structure regression Source: Ensembl
  2. anterior/posterior pattern specification Source: Ensembl
  3. apoptotic process involved in patterning of blood vessels Source: Ensembl
  4. bone development Source: Ensembl
  5. bone remodeling Source: Ensembl
  6. branching involved in mammary gland duct morphogenesis Source: Ensembl
  7. canonical Wnt signaling pathway Source: Ensembl
  8. cell-cell signaling involved in mammary gland development Source: Ensembl
  9. cell migration involved in gastrulation Source: Ensembl
  10. cholesterol metabolic process Source: Ensembl
  11. embryonic digit morphogenesis Source: Ensembl
  12. extracellular matrix-cell signaling Source: Ensembl
  13. gastrulation with mouth forming second Source: Ensembl
  14. osteoblast development Source: Ensembl
  15. positive regulation of osteoblast proliferation Source: Ensembl
  16. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  17. positive regulation of transcription, DNA-templated Source: Ensembl
  18. regulation of apoptotic process Source: Ensembl
  19. regulation of bone remodeling Source: Ensembl
  20. regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
  21. response to peptide hormone Source: Ensembl
  22. retina vasculature morphogenesis in camera-type eye Source: Ensembl
  23. somatic stem cell maintenance Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Low-density lipoprotein receptor-related protein 5Imported
Gene namesi
Name:LRP5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6697. LRP5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiE9PHY1.
ExpressionAtlasiE9PHY1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PHY1.
SMRiE9PHY1. Positions 32-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118968.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF00058. Ldl_recept_b. 5 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00135. LY. 7 hits.
[Graphical view]
PROSITEiPS51120. LDLRB. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PHY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAAPPGPPW PLLLLLLLLL ALCGCPAPAA ASPLLLFANR RDVRLVDAGG
60 70 80 90 100
VKLESTIVVS GLEDAAAVDF QFSKGAVYWT DVSEEAIKQT YLNQTGAAVQ
110 120 130 140 150
NVVISGLVSP DGLACDWVGK KLYWTDSETN RIEVANLNGT SRKVLFWQDL
160 170 180 190 200
DQPRAIALDP AHGYMYWTDW GETPRIERAG MDGSTRKIIV DSDIYWPNGL
210 220 230 240 250
TIDLEEQKLY WADAKLSFIH RANLDGSFRQ KVVEGSLTHP FALTLSGDTL
260 270 280 290 300
YWTDWQTRSI HACNKRTGGK RKEILSALYS PMDIQVLSQE RQPFFHTRCE
310 320 330 340 350
EDNGGCSHLC LLSPSEPFYT CACPTGVQLQ DNGRTCKAGA EEVLLLARRT
360 370 380 390 400
DLRRISLDTP DFTDIVLQVD DIRHAIAIDY DPLEGYVYWT DDEVRAIRRA
410 420 430 440 450
YLDGSGAQTL VNTEINDPDG IAVDWVARNL YWTDTGTDRI EVTRLNGTSR
460 470
KILVSEDLDE PRAIALHPVM G
Length:471
Mass (Da):52,432
Last modified:April 5, 2011 - v1
Checksum:i9457467F2F09FCC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000807 Genomic DNA. No translation available.
AP002813 Genomic DNA. No translation available.
KF455408 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000529993; ENSP00000436652; ENSG00000162337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000807 Genomic DNA. No translation available.
AP002813 Genomic DNA. No translation available.
KF455408 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9PHY1.
SMRi E9PHY1. Positions 32-471.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000529993 ; ENSP00000436652 ; ENSG00000162337 .

Organism-specific databases

HGNCi HGNC:6697. LRP5.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118968.

Miscellaneous databases

ChiTaRSi LRP5. human.
NextBioi 35502095.

Gene expression databases

Bgeei E9PHY1.
ExpressionAtlasi E9PHY1. baseline and differential.

Family and domain databases

Gene3Di 2.120.10.30. 2 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view ]
Pfami PF00058. Ldl_recept_b. 5 hits.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00135. LY. 7 hits.
[Graphical view ]
PROSITEi PS51120. LDLRB. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PHY1_HUMAN
AccessioniPrimary (citable) accession number: E9PHY1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3