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E9PHY1

- E9PHY1_HUMAN

UniProt

E9PHY1 - E9PHY1_HUMAN

Protein
Submitted name:

Low-density lipoprotein receptor-related protein 5

Gene

LRP5

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. Wnt-activated receptor activity Source: Ensembl

    GO - Biological processi

    1. anatomical structure regression Source: Ensembl
    2. anterior/posterior pattern specification Source: Ensembl
    3. apoptotic process involved in patterning of blood vessels Source: Ensembl
    4. bone development Source: Ensembl
    5. bone remodeling Source: Ensembl
    6. branching involved in mammary gland duct morphogenesis Source: Ensembl
    7. canonical Wnt signaling pathway Source: Ensembl
    8. cell-cell signaling involved in mammary gland development Source: Ensembl
    9. cell migration involved in gastrulation Source: Ensembl
    10. cholesterol metabolic process Source: Ensembl
    11. embryonic digit morphogenesis Source: Ensembl
    12. extracellular matrix-cell signaling Source: Ensembl
    13. gastrulation with mouth forming second Source: Ensembl
    14. osteoblast development Source: Ensembl
    15. positive regulation of osteoblast proliferation Source: Ensembl
    16. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    17. positive regulation of transcription, DNA-templated Source: Ensembl
    18. regulation of apoptotic process Source: Ensembl
    19. regulation of bone remodeling Source: Ensembl
    20. regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
    21. response to peptide hormone Source: Ensembl
    22. retina vasculature morphogenesis in camera-type eye Source: Ensembl
    23. somatic stem cell maintenance Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Low-density lipoprotein receptor-related protein 5Imported
    Gene namesi
    Name:LRP5Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:6697. LRP5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiE9PHY1.
    BgeeiE9PHY1.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PHY1.
    SMRiE9PHY1. Positions 32-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    EGF-like domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.120.10.30. 2 hits.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR000033. LDLR_classB_rpt.
    [Graphical view]
    PfamiPF00058. Ldl_recept_b. 5 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    SM00135. LY. 7 hits.
    [Graphical view]
    PROSITEiPS51120. LDLRB. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PHY1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAAPPGPPW PLLLLLLLLL ALCGCPAPAA ASPLLLFANR RDVRLVDAGG    50
    VKLESTIVVS GLEDAAAVDF QFSKGAVYWT DVSEEAIKQT YLNQTGAAVQ 100
    NVVISGLVSP DGLACDWVGK KLYWTDSETN RIEVANLNGT SRKVLFWQDL 150
    DQPRAIALDP AHGYMYWTDW GETPRIERAG MDGSTRKIIV DSDIYWPNGL 200
    TIDLEEQKLY WADAKLSFIH RANLDGSFRQ KVVEGSLTHP FALTLSGDTL 250
    YWTDWQTRSI HACNKRTGGK RKEILSALYS PMDIQVLSQE RQPFFHTRCE 300
    EDNGGCSHLC LLSPSEPFYT CACPTGVQLQ DNGRTCKAGA EEVLLLARRT 350
    DLRRISLDTP DFTDIVLQVD DIRHAIAIDY DPLEGYVYWT DDEVRAIRRA 400
    YLDGSGAQTL VNTEINDPDG IAVDWVARNL YWTDTGTDRI EVTRLNGTSR 450
    KILVSEDLDE PRAIALHPVM G 471
    Length:471
    Mass (Da):52,432
    Last modified:April 5, 2011 - v1
    Checksum:i9457467F2F09FCC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000807 Genomic DNA. No translation available.
    AP002813 Genomic DNA. No translation available.
    KF455408 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000529993; ENSP00000436652; ENSG00000162337.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000807 Genomic DNA. No translation available.
    AP002813 Genomic DNA. No translation available.
    KF455408 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E9PHY1.
    SMRi E9PHY1. Positions 32-471.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000529993 ; ENSP00000436652 ; ENSG00000162337 .

    Organism-specific databases

    HGNCi HGNC:6697. LRP5.
    GenAtlasi Search...

    Miscellaneous databases

    NextBioi 35502095.

    Gene expression databases

    ArrayExpressi E9PHY1.
    Bgeei E9PHY1.

    Family and domain databases

    Gene3Di 2.120.10.30. 2 hits.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR000033. LDLR_classB_rpt.
    [Graphical view ]
    Pfami PF00058. Ldl_recept_b. 5 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    SM00135. LY. 7 hits.
    [Graphical view ]
    PROSITEi PS51120. LDLRB. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE9PHY1_HUMAN
    AccessioniPrimary (citable) accession number: E9PHY1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3