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E9PHY1

- E9PHY1_HUMAN

UniProt

E9PHY1 - E9PHY1_HUMAN

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Protein
Submitted name: Low-density lipoprotein receptor-related protein 5
Gene
LRP5
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. Wnt-activated receptor activity Source: Ensembl

GO - Biological processi

  1. anatomical structure regression Source: Ensembl
  2. anterior/posterior pattern specification Source: Ensembl
  3. apoptotic process involved in patterning of blood vessels Source: Ensembl
  4. bone development Source: Ensembl
  5. bone remodeling Source: Ensembl
  6. branching involved in mammary gland duct morphogenesis Source: Ensembl
  7. canonical Wnt signaling pathway Source: Ensembl
  8. cell migration involved in gastrulation Source: Ensembl
  9. cell-cell signaling involved in mammary gland development Source: Ensembl
  10. cholesterol metabolic process Source: Ensembl
  11. embryonic digit morphogenesis Source: Ensembl
  12. extracellular matrix-cell signaling Source: Ensembl
  13. gastrulation with mouth forming second Source: Ensembl
  14. osteoblast development Source: Ensembl
  15. positive regulation of osteoblast proliferation Source: Ensembl
  16. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  17. positive regulation of transcription, DNA-templated Source: Ensembl
  18. regulation of apoptotic process Source: Ensembl
  19. regulation of bone remodeling Source: Ensembl
  20. regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
  21. response to peptide hormone Source: Ensembl
  22. retina vasculature morphogenesis in camera-type eye Source: Ensembl
  23. somatic stem cell maintenance Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Low-density lipoprotein receptor-related protein 5Imported
Gene namesi
Name:LRP5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6697. LRP5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiE9PHY1.
BgeeiE9PHY1.

Structurei

3D structure databases

ProteinModelPortaliE9PHY1.
SMRiE9PHY1. Positions 32-471.

Family & Domainsi

Keywords - Domaini

EGF-like domainSAAS annotations, RepeatSAAS annotations, Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF00058. Ldl_recept_b. 5 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00135. LY. 7 hits.
[Graphical view]
PROSITEiPS51120. LDLRB. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PHY1-1 [UniParc]FASTAAdd to Basket

« Hide

MEAAPPGPPW PLLLLLLLLL ALCGCPAPAA ASPLLLFANR RDVRLVDAGG    50
VKLESTIVVS GLEDAAAVDF QFSKGAVYWT DVSEEAIKQT YLNQTGAAVQ 100
NVVISGLVSP DGLACDWVGK KLYWTDSETN RIEVANLNGT SRKVLFWQDL 150
DQPRAIALDP AHGYMYWTDW GETPRIERAG MDGSTRKIIV DSDIYWPNGL 200
TIDLEEQKLY WADAKLSFIH RANLDGSFRQ KVVEGSLTHP FALTLSGDTL 250
YWTDWQTRSI HACNKRTGGK RKEILSALYS PMDIQVLSQE RQPFFHTRCE 300
EDNGGCSHLC LLSPSEPFYT CACPTGVQLQ DNGRTCKAGA EEVLLLARRT 350
DLRRISLDTP DFTDIVLQVD DIRHAIAIDY DPLEGYVYWT DDEVRAIRRA 400
YLDGSGAQTL VNTEINDPDG IAVDWVARNL YWTDTGTDRI EVTRLNGTSR 450
KILVSEDLDE PRAIALHPVM G 471
Length:471
Mass (Da):52,432
Last modified:April 5, 2011 - v1
Checksum:i9457467F2F09FCC9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000807 Genomic DNA. No translation available.
AP002813 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000529993; ENSP00000436652; ENSG00000162337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000807 Genomic DNA. No translation available.
AP002813 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9PHY1.
SMRi E9PHY1. Positions 32-471.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000529993 ; ENSP00000436652 ; ENSG00000162337 .

Organism-specific databases

HGNCi HGNC:6697. LRP5.
GenAtlasi Search...

Miscellaneous databases

NextBioi 35502095.

Gene expression databases

ArrayExpressi E9PHY1.
Bgeei E9PHY1.

Family and domain databases

Gene3Di 2.120.10.30. 2 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view ]
Pfami PF00058. Ldl_recept_b. 5 hits.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00135. LY. 7 hits.
[Graphical view ]
PROSITEi PS51120. LDLRB. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PHY1_HUMAN
AccessioniPrimary (citable) accession number: E9PHY1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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