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Protein
Submitted name:

Low-density lipoprotein receptor-related protein 5

Gene

LRP5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Low-density lipoprotein receptor-related protein 5Imported
Gene namesi
Name:LRP5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000162337.11
HGNCiHGNC:6697 LRP5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162337

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_500324503932 – 471Sequence analysisAdd BLAST440

Proteomic databases

MaxQBiE9PHY1
PeptideAtlasiE9PHY1
PRIDEiE9PHY1

Expressioni

Gene expression databases

BgeeiENSG00000162337
ExpressionAtlasiE9PHY1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PHY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati75 – 119LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati120 – 162LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati163 – 206LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati207 – 249LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati250 – 290LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati385 – 427LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati428 – 470LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IPT4 Eukaryota
ENOG410XSY5 LUCA
GeneTreeiENSGT00760000118968

Family and domain databases

Gene3Di2.120.10.30, 2 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR000033 LDLR_classB_rpt
PfamiView protein in Pfam
PF00058 Ldl_recept_b, 5 hits
SMARTiView protein in SMART
SM00135 LY, 7 hits
PROSITEiView protein in PROSITE
PS51120 LDLRB, 7 hits

Sequencei

Sequence statusi: Complete.

E9PHY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAPPGPPW PLLLLLLLLL ALCGCPAPAA ASPLLLFANR RDVRLVDAGG
60 70 80 90 100
VKLESTIVVS GLEDAAAVDF QFSKGAVYWT DVSEEAIKQT YLNQTGAAVQ
110 120 130 140 150
NVVISGLVSP DGLACDWVGK KLYWTDSETN RIEVANLNGT SRKVLFWQDL
160 170 180 190 200
DQPRAIALDP AHGYMYWTDW GETPRIERAG MDGSTRKIIV DSDIYWPNGL
210 220 230 240 250
TIDLEEQKLY WADAKLSFIH RANLDGSFRQ KVVEGSLTHP FALTLSGDTL
260 270 280 290 300
YWTDWQTRSI HACNKRTGGK RKEILSALYS PMDIQVLSQE RQPFFHTRCE
310 320 330 340 350
EDNGGCSHLC LLSPSEPFYT CACPTGVQLQ DNGRTCKAGA EEVLLLARRT
360 370 380 390 400
DLRRISLDTP DFTDIVLQVD DIRHAIAIDY DPLEGYVYWT DDEVRAIRRA
410 420 430 440 450
YLDGSGAQTL VNTEINDPDG IAVDWVARNL YWTDTGTDRI EVTRLNGTSR
460 470
KILVSEDLDE PRAIALHPVM G
Length:471
Mass (Da):52,432
Last modified:April 5, 2011 - v1
Checksum:i9457467F2F09FCC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000807 Genomic DNA No translation available.
AP002813 Genomic DNA No translation available.
KF455408 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000529993; ENSP00000436652; ENSG00000162337
UCSCiuc058enc.1 human

Similar proteinsi

Entry informationi

Entry nameiE9PHY1_HUMAN
AccessioniPrimary (citable) accession number: E9PHY1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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