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Protein
Submitted name:

Lysosomal acid phosphatase

Gene

ACP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Lysosomal acid phosphataseImported
Gene namesi
Name:ACP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000134575.9
HGNCiHGNC:123 ACP2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei318 – 341HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134575

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_500324284631 – 360Sequence analysisAdd BLAST330

Proteomic databases

MaxQBiE9PHY0
PeptideAtlasiE9PHY0
PRIDEiE9PHY0

Expressioni

Gene expression databases

BgeeiENSG00000134575
ExpressionAtlasiE9PHY0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PHY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3720 Eukaryota
ENOG410ZVBQ LUCA
GeneTreeiENSGT00530000062956

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
Gene3Di3.40.50.1240, 2 hits
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR029033 His_PPase_superfam
PfamiView protein in Pfam
PF00328 His_Phos_2, 2 hits
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit
PS00778 HIS_ACID_PHOSPHAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

E9PHY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLLY RHGDRSPVKT
60 70 80 90 100
YPKDPYQEEE WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV
110 120 130 140 150
YVRSTDFDRT LMSAEANLAG LFPPNGMQRF NPNISWQPIP VHTVPITEDR
160 170 180 190 200
QTHGLRLPPW ASPQTMQRLS RLKDFSFRFL FGIYQQAEKA RLQGGVLLAQ
210 220 230 240 250
IRKNLTLMAT TSQLPKLLVY SAHDTTLVAL QMALDVYNGE QAPYASCHIF
260 270 280 290 300
ELYQEDSGNF SVEMYFRNES DKAPWPLSLP GCPHRCPLQD FLRLTEPVVP
310 320 330 340 350
KDWQQECQLA SGPADTEVIV ALAVCGSILF LLIVLLLTVL FRMQAQPPGY
360
RHVADGEDHA
Length:360
Mass (Da):40,990
Last modified:April 5, 2011 - v1
Checksum:i3EB3A21AF99FF6A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018410 Genomic DNA No translation available.
RefSeqiNP_001289420.1, NM_001302491.1
UniGeneiHs.532492

Genome annotation databases

EnsembliENST00000529444; ENSP00000436658; ENSG00000134575
GeneIDi53
UCSCiuc010rhg.3 human

Similar proteinsi

Entry informationi

Entry nameiE9PHY0_HUMAN
AccessioniPrimary (citable) accession number: E9PHY0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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