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Protein
Submitted name:

Ankyrin-2

Gene

ANK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Ankyrin-2Imported
Gene namesi
Name:ANK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:493. ANK2.

PTM / Processingi

Proteomic databases

EPDiE9PHW9.
PaxDbiE9PHW9.

Expressioni

Gene expression databases

BgeeiE9PHW9.
ExpressionAtlasiE9PHW9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349588.

Structurei

3D structure databases

ProteinModelPortaliE9PHW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 828784ANK_REP_REGIONInterPro annotationAdd
BLAST
Domaini981 – 1121141ZU5InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 20 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR030301. Ankyrin-B.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000906. ZU5_dom.
[Graphical view]
PANTHERiPTHR24123:SF17. PTHR24123:SF17. 3 hits.
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 7 hits.
PF00791. ZU5. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 23 hits.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 20 hits.
PS51145. ZU5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PHW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNEDAAQKS DSGEKFNGSS QRRKRPKKVT CPQMKPEAAN IEKSDSNASF
60 70 80 90 100
LRAARAGNLD KVVEYLKGGI DINTCNQNGL NALHLAAKEG HVGLVQELLG
110 120 130 140 150
RGSSVDSATK KGNTALHIAS LAGQAEVVKV LVKEGANINA QSQNGFTPLY
160 170 180 190 200
MAAQENHIDV VKYLLENGAN QSTATEDGFT PLAVALQQGH NQAVAILLEN
210 220 230 240 250
DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKMM VNRTTESGFT
260 270 280 290 300
PLHIAAHYGN VNVATLLLNR GAAVDFTARN GITPLHVASK RGNTNMVKLL
310 320 330 340 350
LDRGGQIDAK TRDGLTPLHC AARSGHDQVV ELLLERGAPL LARTKNGLSP
360 370 380 390 400
LHMAAQGDHV ECVKHLLQHK APVDDVTLDY LTALHVAAHC GHYRVTKLLL
410 420 430 440 450
DKRANPNARA LNGFTPLHIA CKKNRIKVME LLVKYGASIQ AITESGLTPI
460 470 480 490 500
HVAAFMGHLN IVLLLLQNGA SPDVTNIRGE TALHMAARAG QVEVVRCLLR
510 520 530 540 550
NGALVDARAR EEQTPLHIAS RLGKTEIVQL LLQHMAHPDA ATTNGYTPLH
560 570 580 590 600
ISAREGQVDV ASVLLEAGAA HSLATKKGFT PLHVAAKYGS LDVAKLLLQR
610 620 630 640 650
RAAADSAGKN GLTPLHVAAH YDNQKVALLL LEKGASPHAT AKNGYTPLHI
660 670 680 690 700
AAKKNQMQIA STLLNYGAET NIVTKQGVTP LHLASQEGHT DMVTLLLDKG
710 720 730 740 750
ANIHMSTKSG LTSLHLAAQE DKVNVADILT KHGADQDAHT KLGYTPLIVA
760 770 780 790 800
CHYGNVKMVN FLLKQGANVN AKTKNGYTPL HQAAQQGHTH IINVLLQHGA
810 820 830 840 850
KPNATTANGN TALAIAKRLG YISVVDTLKV VTEEVTTTTT TITEKHKLNV
860 870 880 890 900
PETMTEVLDV SDEEGDDTMT GDGGEYLRPE DLKELGDDSL PSSQFLDGMN
910 920 930 940 950
YLRYSLEGGR SDSLRSFSSD RSHTLSHASY LRDSAVMDDS VVIPSHQVST
960 970 980 990 1000
LAKEAERNSY RLSWGTENLD NVALSSSPIH SGFLVSFMVD ARGGAMRGCR
1010 1020 1030 1040 1050
HNGLRIIIPP RKCTAPTRVT CRLVKRHRLA TMPPMVEGEG LASRLIEVGP
1060 1070 1080 1090 1100
SGAQFLGKLH LPTAPPPLNE GESLVSRILQ LGPPGTKFLG PVIVEIPHFA
1110 1120 1130 1140 1150
ALRGKERELV VLRSENGDSW KEHFCDYTED ELNEILNGMD EVLDSPEDLE
1160 1170 1180 1190 1200
KKRICRIITR DFPQYFAVVS RIKQDSNLIG PEGGVLSSTV VPQVQAVFPE
1210 1220 1230 1240 1250
GALTKRIRVG LQAQPMHSEL VKKILGNKAT FSPIVTLEPR RRKFHKPITM
1260 1270 1280 1290 1300
TIPVPKASSD VMLNGFGGDA PTLRLLCSIT GGTTPAQWED ITGTTPLTFV
1310 1320 1330 1340 1350
NECVSFTTNV SARFWLIDCR QIQESVTFAS QVYREIICVP YMAKFVVFAK
1360 1370 1380 1390 1400
SHDPIEARLR CFCMTDDKVD KTLEQQENFA EVARSRDVEV LEGKPIYVDC
1410 1420 1430 1440 1450
FGNLVPLTKS GQHHIFSFFA FKENRLPLFV KVRDTTQEPC GRLSFMKEPK
1460 1470 1480 1490 1500
STRGLVHQAI CNLNITLPIY TKESESDQEQ EEEIDMTSEK NDETESTETS
1510 1520 1530 1540 1550
VLKSHLVNEV PVLASPDLLS EVSEMKQDLI KMTAILTTDV SDKAGSIKVK
1560 1570 1580 1590 1600
ELVKAAEEEP GEPFEIVERV KEDLEKVNEI LRSGTCTRDE SSVQSSRSER
1610 1620 1630 1640 1650
GLVEEEWVIV SDEEIEEARQ KAPLEITEYP CVEVRIDKEI KGKVEKDSTG
1660 1670 1680 1690 1700
LVNYLTDDLN TCVPLPKEQL QTVQDKAGKK CEALAVGRSS EKEGKDIPPD
1710 1720 1730
ETQSTQKQHK PSLGIKKPVR RKLKEKQKQK
Length:1,730
Mass (Da):189,107
Last modified:April 5, 2011 - v1
Checksum:i8B8CDD7984185FDA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1730 – 17301Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004057 Genomic DNA. No translation available.
AC017007 Genomic DNA. No translation available.
AC093617 Genomic DNA. No translation available.
AC093879 Genomic DNA. No translation available.
AC093900 Genomic DNA. No translation available.
AC108042 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000504454; ENSP00000424722; ENSG00000145362.
UCSCiuc062zdc.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004057 Genomic DNA. No translation available.
AC017007 Genomic DNA. No translation available.
AC093617 Genomic DNA. No translation available.
AC093879 Genomic DNA. No translation available.
AC093900 Genomic DNA. No translation available.
AC108042 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PHW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349588.

Proteomic databases

EPDiE9PHW9.
PaxDbiE9PHW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000504454; ENSP00000424722; ENSG00000145362.
UCSCiuc062zdc.1. human.

Organism-specific databases

HGNCiHGNC:493. ANK2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.

Miscellaneous databases

ChiTaRSiANK2. human.

Gene expression databases

BgeeiE9PHW9.
ExpressionAtlasiE9PHW9. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR030301. Ankyrin-B.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000906. ZU5_dom.
[Graphical view]
PANTHERiPTHR24123:SF17. PTHR24123:SF17. 3 hits.
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 7 hits.
PF00791. ZU5. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 23 hits.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 20 hits.
PS51145. ZU5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE9PHW9_HUMAN
AccessioniPrimary (citable) accession number: E9PHW9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.