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Protein

Phospholipid scramblase

Gene

PLSCR4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.UniRule annotation

Cofactori

Ca2+UniRule annotation

Keywordsi

LigandCalciumUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid scramblaseUniRule annotation
Gene namesi
Name:PLSCR4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:16497. PLSCR4.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000114698.

PTM / Processingi

Keywords - PTMi

Lipoprotein, PalmitateUniRule annotation

Proteomic databases

MaxQBiE9PHR9.
PaxDbiE9PHR9.
PeptideAtlasiE9PHR9.
PRIDEiE9PHR9.

Expressioni

Gene expression databases

BgeeiENSG00000114698.
ExpressionAtlasiE9PHR9. baseline and differential.
GenevisibleiE9PHR9. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347038.

Structurei

3D structure databases

ProteinModelPortaliE9PHR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipid scramblase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0621. Eukaryota.
ENOG410XSYS. LUCA.
GeneTreeiENSGT00390000002884.

Family and domain databases

InterProiIPR005552. Scramblase.
[Graphical view]
PANTHERiPTHR23248. PTHR23248. 1 hit.
PfamiPF03803. Scramblase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PHR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGVVPTAPE QPAGEMENQT KPPDPRPDAP PEYNSHFLPG PPGTAVPPPT
60 70 80 90 100
GYPGGLPMGY YSPQQPSTFP LYQPVGGIHP VRYQPGKYPM PNQSVPITWM
110 120 130 140 150
PGPTPMANCP PGLEYLVQLE VQCPPGVTIG FVAEHWNLCR AVYSIQNEKK
160 170 180 190 200
ENVMRVRGPC STYGCGSDSV FEVKSLDGIS NIGSIIRKWN GLLSAMADAD
210 220 230
HFDIHFPLDL DVKMKAMIFG ACFLIDFMYF ERSPPQRSR
Length:239
Mass (Da):26,249
Last modified:April 5, 2011 - v1
Checksum:i9136336E3F1891D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092982 Genomic DNA. No translation available.
RefSeqiNP_001121778.1. NM_001128306.1.
XP_016862410.1. XM_017006921.1.
UniGeneiHs.477869.

Genome annotation databases

EnsembliENST00000383083; ENSP00000372561; ENSG00000114698.
GeneIDi57088.
UCSCiuc010hva.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092982 Genomic DNA. No translation available.
RefSeqiNP_001121778.1. NM_001128306.1.
XP_016862410.1. XM_017006921.1.
UniGeneiHs.477869.

3D structure databases

ProteinModelPortaliE9PHR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347038.

Proteomic databases

MaxQBiE9PHR9.
PaxDbiE9PHR9.
PeptideAtlasiE9PHR9.
PRIDEiE9PHR9.

Protocols and materials databases

DNASUi57088.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383083; ENSP00000372561; ENSG00000114698.
GeneIDi57088.
UCSCiuc010hva.5. human.

Organism-specific databases

CTDi57088.
HGNCiHGNC:16497. PLSCR4.
OpenTargetsiENSG00000114698.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0621. Eukaryota.
ENOG410XSYS. LUCA.
GeneTreeiENSGT00390000002884.

Miscellaneous databases

GenomeRNAii57088.

Gene expression databases

BgeeiENSG00000114698.
ExpressionAtlasiE9PHR9. baseline and differential.
GenevisibleiE9PHR9. HS.

Family and domain databases

InterProiIPR005552. Scramblase.
[Graphical view]
PANTHERiPTHR23248. PTHR23248. 1 hit.
PfamiPF03803. Scramblase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PHR9_HUMAN
AccessioniPrimary (citable) accession number: E9PHR9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: January 18, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.