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Protein
Submitted name:

Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

Gene

MCCC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrialImported
Gene namesi
Name:MCCC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000078070.11
HGNCiHGNC:6936 MCCC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000078070

PTM / Processingi

Proteomic databases

MaxQBiE9PHF7
PeptideAtlasiE9PHF7
PRIDEiE9PHF7

Expressioni

Gene expression databases

BgeeiENSG00000078070
ExpressionAtlasiE9PHF7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PHF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 385Biotin carboxylationInterPro annotationAdd BLAST385
Domaini58 – 255ATP-graspInterPro annotationAdd BLAST198
Domaini534 – 606Lipoyl-bindingInterPro annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili112 – 132Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0238 Eukaryota
COG4770 LUCA
GeneTreeiENSGT00550000074675

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00867 CPSASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

E9PHF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIIQVAKT SAAQAIHPGC GFLSENMEFA ELCKQEGIIF IGPPPSAIRD
60 70 80 90 100
MGIKSTSKSI MAAAGVPVVE GYHGEDQSDQ CLKEHARRIG YPVMIKAVRG
110 120 130 140 150
GGGKGMRIVR SEQEFQEQLE SARREAKKSF NDDAMLIEKF VDTPRHVEVQ
160 170 180 190 200
VFGDHHGNAV YLFERDCSVQ RRHQKIIEEA PAPGIKSEVR KKLGEAAVRA
210 220 230 240 250
AKAVNYVGAG TVEFIMDSKH NFCFMEMNTR LQVEHPVTEM ITGTDLVEWQ
260 270 280 290 300
LRIAAGEKIP LSQEEITLQG HAFEARIYAE DPSNNFMPVA GPLVHLSTPR
310 320 330 340 350
ADPSTRIETG VRQGDEVSVH YDPMIAKLVV WAADRQAALT KLRYSLRQYN
360 370 380 390 400
IVGLHTNIDF LLNLSGHPEF EAGNVHTDFI PQHHKQLLLS RKAAAKESLC
410 420 430 440 450
QAALGLILKE KAMTDTFTLQ AHDQFSPFSS SSGRRLNISY TRNMTLKDGK
460 470 480 490 500
NNVAIAVTYN HDGSYSMQIE DKTFQVLGNL YSEGDCTYLK CSVNGVASKA
510 520 530 540 550
KLIILENTIY LFSKEGSIEI DIPVPKYLSS VSSQETQGGP LAPMTGTIEK
560 570 580 590 600
VFVKAGDKVK AGDSLMVMIA MKMEHTIKSP KDGTVKKVFY REGAQANRHT
610
PLVEFEEEES DKRESE
Length:616
Mass (Da):68,332
Last modified:April 5, 2011 - v1
Checksum:i1629BA54FD70EC17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104641 Genomic DNA No translation available.
AC108741 Genomic DNA No translation available.
RefSeqiXP_006713765.1, XM_006713702.1
XP_016862363.1, XM_017006874.1
XP_016862364.1, XM_017006875.1
UniGeneiHs.47649

Genome annotation databases

EnsembliENST00000492597; ENSP00000419898; ENSG00000078070
GeneIDi56922
UCSCiuc003flg.4 human

Similar proteinsi

Entry informationi

Entry nameiE9PHF7_HUMAN
AccessioniPrimary (citable) accession number: E9PHF7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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