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Protein
Submitted name:

Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

Gene

MCCC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrialImported
Gene namesi
Name:MCCC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:6936. MCCC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000078070.

PTM / Processingi

Proteomic databases

MaxQBiE9PHF7.
PaxDbiE9PHF7.
PeptideAtlasiE9PHF7.
PRIDEiE9PHF7.

Expressioni

Gene expression databases

BgeeiENSG00000078070.
ExpressionAtlasiE9PHF7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265594.

Structurei

3D structure databases

ProteinModelPortaliE9PHF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 385Biotin carboxylationInterPro annotationAdd BLAST385
Domaini58 – 255ATP-graspInterPro annotationAdd BLAST198
Domaini534 – 606Lipoyl-bindingInterPro annotationAdd BLAST73

Phylogenomic databases

eggNOGiKOG0238. Eukaryota.
COG4770. LUCA.
GeneTreeiENSGT00550000074675.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005481. BC-like_N.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00289. Biotin_carb_N. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PHF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIIQVAKT SAAQAIHPGC GFLSENMEFA ELCKQEGIIF IGPPPSAIRD
60 70 80 90 100
MGIKSTSKSI MAAAGVPVVE GYHGEDQSDQ CLKEHARRIG YPVMIKAVRG
110 120 130 140 150
GGGKGMRIVR SEQEFQEQLE SARREAKKSF NDDAMLIEKF VDTPRHVEVQ
160 170 180 190 200
VFGDHHGNAV YLFERDCSVQ RRHQKIIEEA PAPGIKSEVR KKLGEAAVRA
210 220 230 240 250
AKAVNYVGAG TVEFIMDSKH NFCFMEMNTR LQVEHPVTEM ITGTDLVEWQ
260 270 280 290 300
LRIAAGEKIP LSQEEITLQG HAFEARIYAE DPSNNFMPVA GPLVHLSTPR
310 320 330 340 350
ADPSTRIETG VRQGDEVSVH YDPMIAKLVV WAADRQAALT KLRYSLRQYN
360 370 380 390 400
IVGLHTNIDF LLNLSGHPEF EAGNVHTDFI PQHHKQLLLS RKAAAKESLC
410 420 430 440 450
QAALGLILKE KAMTDTFTLQ AHDQFSPFSS SSGRRLNISY TRNMTLKDGK
460 470 480 490 500
NNVAIAVTYN HDGSYSMQIE DKTFQVLGNL YSEGDCTYLK CSVNGVASKA
510 520 530 540 550
KLIILENTIY LFSKEGSIEI DIPVPKYLSS VSSQETQGGP LAPMTGTIEK
560 570 580 590 600
VFVKAGDKVK AGDSLMVMIA MKMEHTIKSP KDGTVKKVFY REGAQANRHT
610
PLVEFEEEES DKRESE
Length:616
Mass (Da):68,332
Last modified:April 5, 2011 - v1
Checksum:i1629BA54FD70EC17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104641 Genomic DNA. No translation available.
AC108741 Genomic DNA. No translation available.
RefSeqiXP_006713765.1. XM_006713702.1.
XP_016862363.1. XM_017006874.1.
XP_016862364.1. XM_017006875.1.
UniGeneiHs.47649.

Genome annotation databases

EnsembliENST00000492597; ENSP00000419898; ENSG00000078070.
GeneIDi56922.
UCSCiuc003flg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104641 Genomic DNA. No translation available.
AC108741 Genomic DNA. No translation available.
RefSeqiXP_006713765.1. XM_006713702.1.
XP_016862363.1. XM_017006874.1.
XP_016862364.1. XM_017006875.1.
UniGeneiHs.47649.

3D structure databases

ProteinModelPortaliE9PHF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265594.

Proteomic databases

MaxQBiE9PHF7.
PaxDbiE9PHF7.
PeptideAtlasiE9PHF7.
PRIDEiE9PHF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000492597; ENSP00000419898; ENSG00000078070.
GeneIDi56922.
UCSCiuc003flg.4. human.

Organism-specific databases

CTDi56922.
HGNCiHGNC:6936. MCCC1.
OpenTargetsiENSG00000078070.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0238. Eukaryota.
COG4770. LUCA.
GeneTreeiENSGT00550000074675.

Miscellaneous databases

ChiTaRSiMCCC1. human.
GenomeRNAii56922.

Gene expression databases

BgeeiENSG00000078070.
ExpressionAtlasiE9PHF7. baseline and differential.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005481. BC-like_N.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00289. Biotin_carb_N. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PHF7_HUMAN
AccessioniPrimary (citable) accession number: E9PHF7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.