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E9PHF0

- E9PHF0_HUMAN

UniProt

E9PHF0 - E9PHF0_HUMAN

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Protein
Submitted name:

Filamin-A

Gene
FLNA
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Filamin-AImported
Gene namesi
Name:FLNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:3754. FLNA.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: HPA
  2. cytoplasm Source: HPA
  3. plasma membrane Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9PHF0.

Expressioni

Gene expression databases

ArrayExpressiE9PHF0.
BgeeiE9PHF0.

Structurei

3D structure databases

ProteinModelPortaliE9PHF0.
SMRiE9PHF0. Positions 1-462, 464-655, 692-780.

Family & Domainsi

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF173. PTHR11915:SF173. 1 hit.
PfamiPF00630. Filamin. 8 hits.
[Graphical view]
SMARTiSM00557. IG_FLMN. 8 hits.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 9 hits.
PROSITEiPS50194. FILAMIN_REPEAT. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PHF0-1 [UniParc]FASTAAdd to Basket

« Hide

MPSGKVAQPT ITDNKDGTVT VRYAPSEAGL HEMDIRYDNM HIPGSPLQFY    50
VDYVNCGHVT AYGPGLTHGV VNKPATFTVN TKDAGEGDDS MRMSHLKVGS 100
AADIPINISE TDLSLLTATV VPPSGREEPC LLKRLRNGHV GISFVPKETG 150
EHLVHVKKNG QHVASSPIPV VISQSEIGDA SRVRVSGQGL HEGHTFEPAE 200
FIIDTRDAGY GGLSLSIEGP SKVDINTEDL EDGTCRVTYC PTEPGNYIIN 250
IKFADQHVPG SPFSVKVTGE GRVKESITRR RRAPSVANVG SHCDLSLKIP 300
EISIQDMTAQ VTSPSGKTHE AEIVEGENHT YCIRFVPAEM GTHTVSVKYK 350
GQHVPGSPFQ FTVGPLGEGG AHKVRAGGPG LERAEAGVPA EFSIWTREAG 400
AGGLAIAVEG PSKAEISFED RKDGSCGVAY VVQEPGDYEV SVKFNEEHIP 450
DSPFVVPVAS PSGDARRLTV SSLQESGLKV NQPASFAVSL NGAKGAIDAK 500
VHSPSGALEE CYVTEIDQDK YAVRFIPREN GVYLIDVKFN GTHIPGSPFK 550
IRVGEPGHGG DPGLVSAYGA GLEGGVTGNP AEFVVNTSNA GAGALSVTID 600
GPSKVKMDCQ ECPEGYRVTY TPMAPGSYLI SIKYGGPYHI GGSPFKAKVT 650
GPRLVSNHSL HETSSVFVDS LTKATCAPQH GAPGPGPADA SKVVAKGLGL 700
SKAYVGQKSS FTVDCSKAGN NMLLVGVHGP RTPCEEILVK HVGSRLYSVS 750
YLLKDKGEYT LVVKWGDEHI PGSPYRVVVP 780
Length:780
Mass (Da):82,524
Last modified:June 28, 2011 - v2
Checksum:i7E8E392BF8E8BBF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX664723 Genomic DNA. No translation available.
BX936346 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000369856; ENSP00000358872; ENSG00000196924.
UCSCiuc011mzn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX664723 Genomic DNA. No translation available.
BX936346 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9PHF0.
SMRi E9PHF0. Positions 1-462, 464-655, 692-780.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9PHF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369856 ; ENSP00000358872 ; ENSG00000196924 .
UCSCi uc011mzn.1. human.

Organism-specific databases

HGNCi HGNC:3754. FLNA.
GenAtlasi Search...

Miscellaneous databases

ChiTaRSi FLNA. human.
NextBioi 35502044.

Gene expression databases

ArrayExpressi E9PHF0.
Bgeei E9PHF0.

Family and domain databases

Gene3Di 2.60.40.10. 9 hits.
InterProi IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view ]
PANTHERi PTHR11915:SF173. PTHR11915:SF173. 1 hit.
Pfami PF00630. Filamin. 8 hits.
[Graphical view ]
SMARTi SM00557. IG_FLMN. 8 hits.
[Graphical view ]
SUPFAMi SSF81296. SSF81296. 9 hits.
PROSITEi PS50194. FILAMIN_REPEAT. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PHF0_HUMAN
AccessioniPrimary (citable) accession number: E9PHF0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 23 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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