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E9PHB6

- E9PHB6_HUMAN

UniProt

E9PHB6 - E9PHB6_HUMAN

Protein

Sodium channel protein

Gene

SCN5A

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

    GO - Molecular functioni

    1. voltage-gated sodium channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel proteinUniRule annotation
    Gene namesi
    Name:SCN5AImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:10593. SCN5A.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiE9PHB6.

    Expressioni

    Gene expression databases

    ArrayExpressiE9PHB6.
    BgeeiE9PHB6.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PHB6.
    SMRiE9PHB6. Positions 1743-1895.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

    Phylogenomic databases

    KOiK04838.

    Family and domain databases

    Gene3Di1.20.120.350. 3 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR008053. Na_channel_a5su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view]
    PfamiPF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.
    PR01666. NACHANNEL5.
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PHB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSTTLQ ESREGLPEEE     50
    APRPQLDLQA SKKLPDLYGN PPQELIGEPL EDLDPFYSTQ KTFIVLNKGK 100
    TIFRFSATNA LYVLSPFHPI RRAAVKILVH SLFNMLIMCT ILTNCVFMAQ 150
    HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV 200
    IIMAYVSENI KLGNLSALRT FRVLRALKTI SVIPGLKTIV GALIQSVKKL 250
    ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNGT NGSVEADGLV 300
    WESLDLYLSD PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH 350
    GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG 400
    SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI 450
    RGVDTVSRSS LEMSPLAPVN SHERRSKRRK RMSSGTEECG EDRLPKSDSE 500
    DGPRAMNHLS LTRGLSRTSM KPRSSRGSIF TFRRRDLGSE ADFADDENST 550
    AGESESHHTS LLVPWPLRRT SAQGQPSPGT SAPGHALHGK KNSTVDCNGV 600
    VSLLGAGDPE ATSPGSHLLR PVMLEHPPDT TTPSEEPGGP QMLTSQAPCV 650
    DGFEEPGARQ RALSAVSVLT SALEELEESR HKCPPCWNRL AQRYLIWECC 700
    PLWMSIKQGV KLVVMDPFTD LTITMCIVLN TLFMALEHYN MTSEFEEMLQ 750
    VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG WNIFDSIIVI LSLMELGLSR 800
    MSNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG NLTLVLAIIV 850
    FIFAVVGMQL FGKNYSELRD SDSGLLPRWH MMDFFHAFLI IFRILCGEWI 900
    ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP 950
    DEDREMNNLQ LALARIQRGL RFVKRTTWDF CCGLLRQRPQ KPAALAAQGQ 1000
    LPSCIATPYS PPPPETEKVP PTRKETRFEE GEQPGQGTPG DPEPVCVPIA 1050
    VAESDTDDQE EDEENSLGTE EESSKQESQP VSGGPEAPPD SRTWSQVSAT 1100
    ASSEAEASAS QADWRQQWKA EPQAPGCGET PEDSCSEGST ADMTNTAELL 1150
    EQIPDLGQDV KDPEDCFTEG CVRRCPCCAV DTTQAPGKVW WRLRKTCYHI 1200
    VEHSWFETFI IFMILLSSGA LAFEDIYLEE RKTIKVLLEY ADKMFTYVFV 1250
    LEMLLKWVAY GFKKYFTNAW CWLDFLIVDV SLVSLVANTL GFAEMGPIKS 1300
    LRTLRALRPL RALSRFEGMR VVVNALVGAI PSIMNVLLVC LIFWLIFSIM 1350
    GVNLFAGKFG RCINQTEGDL PLNYTIVNNK SQCESLNLTG ELYWTKVKVN 1400
    FDNVGAGYLA LLQVATFKGW MDIMYAAVDS RGYEEQPQWE YNLYMYIYFV 1450
    IFIIFGSFFT LNLFIGVIID NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL 1500
    GSKKPQKPIP RPLNKYQGFI FDIVTKQAFD VTIMFLICLN MVTMMVETDD 1550
    QSPEKINILA KINLLFVAIF TGTVLSDIIQ KYFFSPTLFR VIRLARIGRI 1600
    LRLIRGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIYSI FGMANFAYVK 1650
    WEAGIDDMFN FQTFANSMLC LFQITTSAGW DGLLSPILNT GPPYCDPTLP 1700
    NSNGSRGDCG SPAVGILFFT TYIIISFLIV VNMYIAIILE NFSVATEEST 1750
    EPLSEDDFDM FYEIWEKFDP EATQFIEYSV LSDFADALSE PLRIAKPNQI 1800
    SLINMDLPMV SGDRIHCMDI LFAFTKRVLG ESGEMDALKI QMEEKFMAAN 1850
    PSKISYEPIT TTLRRKHEEV SAMVIQRAFR RHLLQRSLKH ASFLFRQQAG 1900
    SGLSEEDAPE REGLIAYVMS ENFSRPLGPP SSSSISSTSF PPSYDSVTRA 1950
    TSDNLQVRGS DYSHSEDLAD FPPSPDRDRE SIV 1983
    Length:1,983
    Mass (Da):223,100
    Last modified:April 5, 2011 - v1
    Checksum:i579B086E9266CFDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006241 Genomic DNA. No translation available.
    RefSeqiNP_001153632.1. NM_001160160.1.
    UniGeneiHs.517898.

    Genome annotation databases

    EnsembliENST00000455624; ENSP00000399524; ENSG00000183873.
    GeneIDi6331.
    KEGGihsa:6331.
    UCSCiuc021wvk.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006241 Genomic DNA. No translation available.
    RefSeqi NP_001153632.1. NM_001160160.1.
    UniGenei Hs.517898.

    3D structure databases

    ProteinModelPortali E9PHB6.
    SMRi E9PHB6. Positions 1743-1895.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9PHB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000455624 ; ENSP00000399524 ; ENSG00000183873 .
    GeneIDi 6331.
    KEGGi hsa:6331.
    UCSCi uc021wvk.1. human.

    Organism-specific databases

    CTDi 6331.
    HGNCi HGNC:10593. SCN5A.
    GenAtlasi Search...

    Phylogenomic databases

    KOi K04838.

    Miscellaneous databases

    GenomeRNAii 6331.
    NextBioi 24578.

    Gene expression databases

    ArrayExpressi E9PHB6.
    Bgeei E9PHB6.

    Family and domain databases

    Gene3Di 1.20.120.350. 3 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR008053. Na_channel_a5su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view ]
    Pfami PF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    PR01666. NACHANNEL5.
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE9PHB6_HUMAN
    AccessioniPrimary (citable) accession number: E9PHB6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3