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Protein
Submitted name:

Transcription factor 4

Gene

TCF4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor 4Imported
Submitted name:
Transcription factor 4, isoform CRA_eImported
Gene namesi
Name:TCF4Imported
ORF Names:hCG_1811800Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:11634. TCF4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiE9PH57. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346440.

Structurei

3D structure databases

SMRiE9PH57. Positions 671-730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini670 – 72354BHLH (basic helix-loop-helix)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG3910. Eukaryota.
ENOG410XYUA. LUCA.
GeneTreeiENSGT00510000046438.
OMAiSNHMGQM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PH57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSKRLEKIP QVPLLFPFIF IILTNYSKME GAVESQPSFF KTSQDIVTCT
60 70 80 90 100
WVENCYSSFS RRPLEQMFCK HQSKNIISWT GMVAHTCNPS TLGGQGLCDF
110 120 130 140 150
AKMHHQQRMA ALGTDKELSD LLDFSAMFSP PVSSGKNGPT SLASGHFTGS
160 170 180 190 200
NVEDRSSSGS WGNGGHPSPS RNYGDGTPYD HMTSRDLGSH DNLSPPFVNS
210 220 230 240 250
RIQSKTERGS YSSYGRESNL QGCHQQSLLG GDMDMGNPGT LSPTKPGSQY
260 270 280 290 300
YQYSSNNPRR RPLHSSAMEV QTKKVRKVPP GLPSSVYAPS ASTADYNRDS
310 320 330 340 350
PGYPSSKPAT STFPSSFFMQ DGHHSSDPWS SSSGMNQPGY AGMLGNSSHI
360 370 380 390 400
PQSSSYCSLH PHERLSYPSH SSADINSSLP PMSTFHRSGT NHYSTSSCTP
410 420 430 440 450
PANGTDSIMA NRGSGAAGSS QTGDALGKAL ASIYSPDHTN NSFSSNPSTP
460 470 480 490 500
VGSPPSLSAG TAVWSRNGGQ ASSSPNYEGP LHSLQSRIED RLERLDDAIH
510 520 530 540 550
VLRNHAVGPS TAMPGGHGDM HGIIGPSHNG AMGGLGSGYG TGLLSANRHS
560 570 580 590 600
LMVGTHREDG VALRGSHSLL PNQVPVPQLP VQSATSPDLN PPQDPYRGMP
610 620 630 640 650
PGLQGQSVSS GSSEIKSDDE GDENLQDTKS SEDKKLDDDK KDIKSITRSR
660 670 680 690 700
SSNNDDEDLT PEQKAEREKE RRMANNARER LRVRDINEAF KELGRMVQLH
710 720 730 740 750
LKSDKPQTKL LILHQAVAVI LSLEQQVRER NLNPKAACLK RREEEKVSSE
760 770
PPPLSLAGPH PGMGDASNHM GQM
Length:773
Mass (Da):83,426
Last modified:October 29, 2014 - v2
Checksum:i18FDDD76D52E62AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013587 Genomic DNA. No translation available.
AC018994 Genomic DNA. No translation available.
AC090383 Genomic DNA. No translation available.
AC090684 Genomic DNA. No translation available.
AC091103 Genomic DNA. No translation available.
KF459816 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW63021.1.
RefSeqiNP_001230155.2. NM_001243226.2.
UniGeneiHs.605153.
Hs.742885.

Genome annotation databases

EnsembliENST00000398339; ENSP00000381382; ENSG00000196628.
GeneIDi6925.
UCSCiuc002lga.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013587 Genomic DNA. No translation available.
AC018994 Genomic DNA. No translation available.
AC090383 Genomic DNA. No translation available.
AC090684 Genomic DNA. No translation available.
AC091103 Genomic DNA. No translation available.
KF459816 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW63021.1.
RefSeqiNP_001230155.2. NM_001243226.2.
UniGeneiHs.605153.
Hs.742885.

3D structure databases

SMRiE9PH57. Positions 671-730.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000346440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398339; ENSP00000381382; ENSG00000196628.
GeneIDi6925.
UCSCiuc002lga.4. human.

Organism-specific databases

CTDi6925.
HGNCiHGNC:11634. TCF4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3910. Eukaryota.
ENOG410XYUA. LUCA.
GeneTreeiENSGT00510000046438.
OMAiSNHMGQM.

Miscellaneous databases

ChiTaRSiTCF4. human.
GenomeRNAii6925.
NextBioi27093.

Gene expression databases

ExpressionAtlasiE9PH57. baseline and differential.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE.
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PH57_HUMAN
AccessioniPrimary (citable) accession number: E9PH57
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 29, 2014
Last modified: May 11, 2016
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.