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Protein
Submitted name:

Amyloid beta A4 protein

Gene

APP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Amyloid beta A4 proteinImported
Gene namesi
Name:APPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:620. APP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei645 – 66723HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 714697Sequence analysisPRO_5003242798Add
BLAST

Proteomic databases

PaxDbiE9PG40.
PRIDEiE9PG40.

Expressioni

Gene expression databases

BgeeiE9PG40.
ExpressionAtlasiE9PG40. baseline and differential.
GenevisibleiE9PG40. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000284981.

Structurei

3D structure databases

ProteinModelPortaliE9PG40.
SMRiE9PG40. Positions 19-133, 231-286, 315-510, 627-672, 685-712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 28551BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili369 – 40335Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3540. Eukaryota.
ENOG410ZW2A. LUCA.
GeneTreeiENSGT00530000063252.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 2 hits.
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTiSM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PG40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPGLALLLL AAWTARALEV YPELQITNVV EANQPVTIQN WCKRGRKQCK
60 70 80 90 100
THPHFVIPYR CLVGEFVSDA LLVPDKCKFL HQERMDVCET HLHWHTVAKE
110 120 130 140 150
TCSEKSTNLH DYGMLLPCGI DKFRGVEFVC CPLAEESDNV DSADAEEDDS
160 170 180 190 200
DVWWGGADTD YADGSEDKVV EVAEEEEVAE VEEEEADDDE DDEDGDEVEE
210 220 230 240 250
EAEEPYEEAT ERTTSIATTT TTTTESVEEV VREVCSEQAE TGPCRAMISR
260 270 280 290 300
WYFDVTEGKC APFFYGGCGG NRNNFDTEEY CMAVCGSAMS QSLLKTTQEP
310 320 330 340 350
LARDPVKLPT TAASTPDAVD KYLETPGDEN EHAHFQKAKE RLEAKHRERM
360 370 380 390 400
SQVMREWEEA ERQAKNLPKA DKKAVIQHFQ EKVESLEQEA ANERQQLVET
410 420 430 440 450
HMARVEAMLN DRRRLALENY ITALQAVPPR PRHVFNMLKK YVRAEQKDRQ
460 470 480 490 500
HTLKHFEHVR MVDPKKAAQI RSQVMTHLRV IYERMNQSLS LLYNVPAVAE
510 520 530 540 550
EIQDEVDELL QKEQNYSDDV LANMISEPRI SYGNDALMPS LTETKTTVEL
560 570 580 590 600
LPVNGEFSLD DLQPWHSFGA DSVPANTENE VEPVDARPAA DRGLTTRPGS
610 620 630 640 650
GLTNIKTEEI SEVKMDAEFR HDSGYEVHHQ KLVFFAEDVG SNKGAIIGLM
660 670 680 690 700
VGGVVIATVI VITLVMLKKK QYTSIHHGVV EVDAAVTPEE RHLSKMQQNG
710
YENPTYKFFE QMQN
Length:714
Mass (Da):80,833
Last modified:April 5, 2011 - v1
Checksum:i68CC52E6F29B777B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001442 Genomic DNA. No translation available.
AP001443 Genomic DNA. No translation available.
KF457122 Genomic DNA. No translation available.
KF457123 Genomic DNA. No translation available.
KF457130 Genomic DNA. No translation available.
KF510514 Genomic DNA. No translation available.
RefSeqiNP_001129602.1. NM_001136130.2.
UniGeneiHs.434980.

Genome annotation databases

EnsembliENST00000439274; ENSP00000398879; ENSG00000142192.
GeneIDi351.
UCSCiuc011ach.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001442 Genomic DNA. No translation available.
AP001443 Genomic DNA. No translation available.
KF457122 Genomic DNA. No translation available.
KF457123 Genomic DNA. No translation available.
KF457130 Genomic DNA. No translation available.
KF510514 Genomic DNA. No translation available.
RefSeqiNP_001129602.1. NM_001136130.2.
UniGeneiHs.434980.

3D structure databases

ProteinModelPortaliE9PG40.
SMRiE9PG40. Positions 19-133, 231-286, 315-510, 627-672, 685-712.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000284981.

Proteomic databases

PaxDbiE9PG40.
PRIDEiE9PG40.

Protocols and materials databases

DNASUi351.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439274; ENSP00000398879; ENSG00000142192.
GeneIDi351.
UCSCiuc011ach.3. human.

Organism-specific databases

CTDi351.
HGNCiHGNC:620. APP.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3540. Eukaryota.
ENOG410ZW2A. LUCA.
GeneTreeiENSGT00530000063252.

Miscellaneous databases

ChiTaRSiAPP. human.
GenomeRNAii351.

Gene expression databases

BgeeiE9PG40.
ExpressionAtlasiE9PG40. baseline and differential.
GenevisibleiE9PG40. HS.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 2 hits.
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTiSM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 21."
    Chromosome 21 mapping and sequencing consortium
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE9PG40_HUMAN
AccessioniPrimary (citable) accession number: E9PG40
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.