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E9PG40

- E9PG40_HUMAN

UniProt

E9PG40 - E9PG40_HUMAN

Protein
Submitted name:

Amyloid beta A4 protein

Gene

APP

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. heparin binding Source: InterPro
    2. serine-type endopeptidase inhibitor activity Source: InterPro
    3. transition metal ion binding Source: InterPro

    GO - Biological processi

    1. nervous system development Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Amyloid beta A4 proteinImported
    Gene namesi
    Name:APPImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:620. APP.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: HPA
    2. integral component of membrane Source: InterPro
    3. intracellular membrane-bounded organelle Source: HPA

    PTM / Processingi

    Proteomic databases

    PRIDEiE9PG40.

    Expressioni

    Gene expression databases

    ArrayExpressiE9PG40.
    BgeeiE9PG40.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PG40.
    SMRiE9PG40. Positions 19-136, 231-286, 315-510, 627-672, 685-712.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 BPTI/Kunitz inhibitor domain.UniRule annotation

    Phylogenomic databases

    KOiK04520.

    Family and domain databases

    Gene3Di3.30.1490.140. 1 hit.
    3.90.570.10. 1 hit.
    4.10.230.10. 1 hit.
    4.10.410.10. 1 hit.
    InterProiIPR008155. Amyloid_glyco.
    IPR013803. Amyloid_glyco_Abeta.
    IPR011178. Amyloid_glyco_Cu-bd.
    IPR024329. Amyloid_glyco_E2_domain.
    IPR019744. Amyloid_glyco_extracell_CS.
    IPR015849. Amyloid_glyco_heparin-bd.
    IPR019745. Amyloid_glyco_intracell_CS.
    IPR028866. APP.
    IPR019543. APP_amyloid_C.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    [Graphical view]
    PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
    PfamiPF10515. APP_amyloid. 1 hit.
    PF12924. APP_Cu_bd. 1 hit.
    PF12925. APP_E2. 1 hit.
    PF02177. APP_N. 1 hit.
    PF03494. Beta-APP. 1 hit.
    PF00014. Kunitz_BPTI. 1 hit.
    [Graphical view]
    PRINTSiPR00203. AMYLOIDA4.
    PR00759. BASICPTASE.
    PR00204. BETAAMYLOID.
    SMARTiSM00131. KU. 1 hit.
    [Graphical view]
    SUPFAMiSSF109843. SSF109843. 1 hit.
    SSF56491. SSF56491. 1 hit.
    SSF57362. SSF57362. 1 hit.
    SSF89811. SSF89811. 1 hit.
    PROSITEiPS00319. A4_EXTRA. 1 hit.
    PS00320. A4_INTRA. 1 hit.
    PS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PG40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPGLALLLL AAWTARALEV YPELQITNVV EANQPVTIQN WCKRGRKQCK    50
    THPHFVIPYR CLVGEFVSDA LLVPDKCKFL HQERMDVCET HLHWHTVAKE 100
    TCSEKSTNLH DYGMLLPCGI DKFRGVEFVC CPLAEESDNV DSADAEEDDS 150
    DVWWGGADTD YADGSEDKVV EVAEEEEVAE VEEEEADDDE DDEDGDEVEE 200
    EAEEPYEEAT ERTTSIATTT TTTTESVEEV VREVCSEQAE TGPCRAMISR 250
    WYFDVTEGKC APFFYGGCGG NRNNFDTEEY CMAVCGSAMS QSLLKTTQEP 300
    LARDPVKLPT TAASTPDAVD KYLETPGDEN EHAHFQKAKE RLEAKHRERM 350
    SQVMREWEEA ERQAKNLPKA DKKAVIQHFQ EKVESLEQEA ANERQQLVET 400
    HMARVEAMLN DRRRLALENY ITALQAVPPR PRHVFNMLKK YVRAEQKDRQ 450
    HTLKHFEHVR MVDPKKAAQI RSQVMTHLRV IYERMNQSLS LLYNVPAVAE 500
    EIQDEVDELL QKEQNYSDDV LANMISEPRI SYGNDALMPS LTETKTTVEL 550
    LPVNGEFSLD DLQPWHSFGA DSVPANTENE VEPVDARPAA DRGLTTRPGS 600
    GLTNIKTEEI SEVKMDAEFR HDSGYEVHHQ KLVFFAEDVG SNKGAIIGLM 650
    VGGVVIATVI VITLVMLKKK QYTSIHHGVV EVDAAVTPEE RHLSKMQQNG 700
    YENPTYKFFE QMQN 714
    Length:714
    Mass (Da):80,833
    Last modified:April 5, 2011 - v1
    Checksum:i68CC52E6F29B777B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP001439 Genomic DNA. No translation available.
    AP001440 Genomic DNA. No translation available.
    AP001441 Genomic DNA. No translation available.
    AP001442 Genomic DNA. No translation available.
    AP001443 Genomic DNA. No translation available.
    KC877827 Genomic DNA. No translation available.
    KC877829 Genomic DNA. No translation available.
    KC877830 Genomic DNA. No translation available.
    KC877833 Genomic DNA. No translation available.
    KC877835 Genomic DNA. No translation available.
    KC877836 Genomic DNA. No translation available.
    KC877837 Genomic DNA. No translation available.
    KC877838 Genomic DNA. No translation available.
    KC877840 Genomic DNA. No translation available.
    KC877846 Genomic DNA. No translation available.
    KC877849 Genomic DNA. No translation available.
    KF454891 Genomic DNA. No translation available.
    KF457122 Genomic DNA. No translation available.
    KF457123 Genomic DNA. No translation available.
    KF457130 Genomic DNA. No translation available.
    KF457131 Genomic DNA. No translation available.
    KF457132 Genomic DNA. No translation available.
    KF457133 Genomic DNA. No translation available.
    KF457134 Genomic DNA. No translation available.
    KF457140 Genomic DNA. No translation available.
    KF510514 Genomic DNA. No translation available.
    KF510515 Genomic DNA. No translation available.
    KF510516 Genomic DNA. No translation available.
    KF510517 Genomic DNA. No translation available.
    KF510518 Genomic DNA. No translation available.
    KF510519 Genomic DNA. No translation available.
    KF510520 Genomic DNA. No translation available.
    KF510521 Genomic DNA. No translation available.
    KF510523 Genomic DNA. No translation available.
    KF510525 Genomic DNA. No translation available.
    KF510526 Genomic DNA. No translation available.
    KF511359 Genomic DNA. No translation available.
    KF511362 Genomic DNA. No translation available.
    KF511363 Genomic DNA. No translation available.
    KF511364 Genomic DNA. No translation available.
    RefSeqiNP_001129602.1. NM_001136130.2.
    UniGeneiHs.434980.

    Genome annotation databases

    EnsembliENST00000439274; ENSP00000398879; ENSG00000142192.
    GeneIDi351.
    KEGGihsa:351.
    UCSCiuc011ach.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP001439 Genomic DNA. No translation available.
    AP001440 Genomic DNA. No translation available.
    AP001441 Genomic DNA. No translation available.
    AP001442 Genomic DNA. No translation available.
    AP001443 Genomic DNA. No translation available.
    KC877827 Genomic DNA. No translation available.
    KC877829 Genomic DNA. No translation available.
    KC877830 Genomic DNA. No translation available.
    KC877833 Genomic DNA. No translation available.
    KC877835 Genomic DNA. No translation available.
    KC877836 Genomic DNA. No translation available.
    KC877837 Genomic DNA. No translation available.
    KC877838 Genomic DNA. No translation available.
    KC877840 Genomic DNA. No translation available.
    KC877846 Genomic DNA. No translation available.
    KC877849 Genomic DNA. No translation available.
    KF454891 Genomic DNA. No translation available.
    KF457122 Genomic DNA. No translation available.
    KF457123 Genomic DNA. No translation available.
    KF457130 Genomic DNA. No translation available.
    KF457131 Genomic DNA. No translation available.
    KF457132 Genomic DNA. No translation available.
    KF457133 Genomic DNA. No translation available.
    KF457134 Genomic DNA. No translation available.
    KF457140 Genomic DNA. No translation available.
    KF510514 Genomic DNA. No translation available.
    KF510515 Genomic DNA. No translation available.
    KF510516 Genomic DNA. No translation available.
    KF510517 Genomic DNA. No translation available.
    KF510518 Genomic DNA. No translation available.
    KF510519 Genomic DNA. No translation available.
    KF510520 Genomic DNA. No translation available.
    KF510521 Genomic DNA. No translation available.
    KF510523 Genomic DNA. No translation available.
    KF510525 Genomic DNA. No translation available.
    KF510526 Genomic DNA. No translation available.
    KF511359 Genomic DNA. No translation available.
    KF511362 Genomic DNA. No translation available.
    KF511363 Genomic DNA. No translation available.
    KF511364 Genomic DNA. No translation available.
    RefSeqi NP_001129602.1. NM_001136130.2.
    UniGenei Hs.434980.

    3D structure databases

    ProteinModelPortali E9PG40.
    SMRi E9PG40. Positions 19-136, 231-286, 315-510, 627-672, 685-712.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9PG40.

    Protocols and materials databases

    DNASUi 351.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000439274 ; ENSP00000398879 ; ENSG00000142192 .
    GeneIDi 351.
    KEGGi hsa:351.
    UCSCi uc011ach.2. human.

    Organism-specific databases

    CTDi 351.
    HGNCi HGNC:620. APP.
    GenAtlasi Search...

    Phylogenomic databases

    KOi K04520.

    Miscellaneous databases

    ChiTaRSi app. human.
    GenomeRNAii 351.
    NextBioi 1445.

    Gene expression databases

    ArrayExpressi E9PG40.
    Bgeei E9PG40.

    Family and domain databases

    Gene3Di 3.30.1490.140. 1 hit.
    3.90.570.10. 1 hit.
    4.10.230.10. 1 hit.
    4.10.410.10. 1 hit.
    InterProi IPR008155. Amyloid_glyco.
    IPR013803. Amyloid_glyco_Abeta.
    IPR011178. Amyloid_glyco_Cu-bd.
    IPR024329. Amyloid_glyco_E2_domain.
    IPR019744. Amyloid_glyco_extracell_CS.
    IPR015849. Amyloid_glyco_heparin-bd.
    IPR019745. Amyloid_glyco_intracell_CS.
    IPR028866. APP.
    IPR019543. APP_amyloid_C.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    [Graphical view ]
    PANTHERi PTHR23103:SF7. PTHR23103:SF7. 1 hit.
    Pfami PF10515. APP_amyloid. 1 hit.
    PF12924. APP_Cu_bd. 1 hit.
    PF12925. APP_E2. 1 hit.
    PF02177. APP_N. 1 hit.
    PF03494. Beta-APP. 1 hit.
    PF00014. Kunitz_BPTI. 1 hit.
    [Graphical view ]
    PRINTSi PR00203. AMYLOIDA4.
    PR00759. BASICPTASE.
    PR00204. BETAAMYLOID.
    SMARTi SM00131. KU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109843. SSF109843. 1 hit.
    SSF56491. SSF56491. 1 hit.
    SSF57362. SSF57362. 1 hit.
    SSF89811. SSF89811. 1 hit.
    PROSITEi PS00319. A4_EXTRA. 1 hit.
    PS00320. A4_INTRA. 1 hit.
    PS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 21."
      Chromosome 21 mapping and sequencing consortium
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE9PG40_HUMAN
    AccessioniPrimary (citable) accession number: E9PG40
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3