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E9PG40

- E9PG40_HUMAN

UniProt

E9PG40 - E9PG40_HUMAN

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Protein
Submitted name:

Amyloid beta A4 protein

Gene

APP

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. heparin binding Source: InterPro
  2. serine-type endopeptidase inhibitor activity Source: InterPro
  3. transition metal ion binding Source: InterPro

GO - Biological processi

  1. nervous system development Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Amyloid beta A4 proteinImported
Gene namesi
Name:APPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:620. APP.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. integral component of membrane Source: InterPro
  3. intracellular membrane-bounded organelle Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9PG40.

Expressioni

Gene expression databases

BgeeiE9PG40.
ExpressionAtlasiE9PG40. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliE9PG40.
SMRiE9PG40. Positions 19-136, 231-286, 315-510, 627-672, 685-712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063252.
KOiK04520.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTiSM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PG40-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPGLALLLL AAWTARALEV YPELQITNVV EANQPVTIQN WCKRGRKQCK
60 70 80 90 100
THPHFVIPYR CLVGEFVSDA LLVPDKCKFL HQERMDVCET HLHWHTVAKE
110 120 130 140 150
TCSEKSTNLH DYGMLLPCGI DKFRGVEFVC CPLAEESDNV DSADAEEDDS
160 170 180 190 200
DVWWGGADTD YADGSEDKVV EVAEEEEVAE VEEEEADDDE DDEDGDEVEE
210 220 230 240 250
EAEEPYEEAT ERTTSIATTT TTTTESVEEV VREVCSEQAE TGPCRAMISR
260 270 280 290 300
WYFDVTEGKC APFFYGGCGG NRNNFDTEEY CMAVCGSAMS QSLLKTTQEP
310 320 330 340 350
LARDPVKLPT TAASTPDAVD KYLETPGDEN EHAHFQKAKE RLEAKHRERM
360 370 380 390 400
SQVMREWEEA ERQAKNLPKA DKKAVIQHFQ EKVESLEQEA ANERQQLVET
410 420 430 440 450
HMARVEAMLN DRRRLALENY ITALQAVPPR PRHVFNMLKK YVRAEQKDRQ
460 470 480 490 500
HTLKHFEHVR MVDPKKAAQI RSQVMTHLRV IYERMNQSLS LLYNVPAVAE
510 520 530 540 550
EIQDEVDELL QKEQNYSDDV LANMISEPRI SYGNDALMPS LTETKTTVEL
560 570 580 590 600
LPVNGEFSLD DLQPWHSFGA DSVPANTENE VEPVDARPAA DRGLTTRPGS
610 620 630 640 650
GLTNIKTEEI SEVKMDAEFR HDSGYEVHHQ KLVFFAEDVG SNKGAIIGLM
660 670 680 690 700
VGGVVIATVI VITLVMLKKK QYTSIHHGVV EVDAAVTPEE RHLSKMQQNG
710
YENPTYKFFE QMQN
Length:714
Mass (Da):80,833
Last modified:April 5, 2011 - v1
Checksum:i68CC52E6F29B777B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001439 Genomic DNA. No translation available.
AP001440 Genomic DNA. No translation available.
AP001441 Genomic DNA. No translation available.
AP001442 Genomic DNA. No translation available.
AP001443 Genomic DNA. No translation available.
KC877827 Genomic DNA. No translation available.
KC877829 Genomic DNA. No translation available.
KC877830 Genomic DNA. No translation available.
KC877833 Genomic DNA. No translation available.
KC877835 Genomic DNA. No translation available.
KC877836 Genomic DNA. No translation available.
KC877837 Genomic DNA. No translation available.
KC877838 Genomic DNA. No translation available.
KC877840 Genomic DNA. No translation available.
KC877846 Genomic DNA. No translation available.
KC877849 Genomic DNA. No translation available.
KF454891 Genomic DNA. No translation available.
KF457122 Genomic DNA. No translation available.
KF457123 Genomic DNA. No translation available.
KF457130 Genomic DNA. No translation available.
KF457131 Genomic DNA. No translation available.
KF457132 Genomic DNA. No translation available.
KF457133 Genomic DNA. No translation available.
KF457134 Genomic DNA. No translation available.
KF457140 Genomic DNA. No translation available.
KF510514 Genomic DNA. No translation available.
KF510515 Genomic DNA. No translation available.
KF510516 Genomic DNA. No translation available.
KF510517 Genomic DNA. No translation available.
KF510518 Genomic DNA. No translation available.
KF510519 Genomic DNA. No translation available.
KF510520 Genomic DNA. No translation available.
KF510521 Genomic DNA. No translation available.
KF510523 Genomic DNA. No translation available.
KF510525 Genomic DNA. No translation available.
KF510526 Genomic DNA. No translation available.
KF511359 Genomic DNA. No translation available.
KF511362 Genomic DNA. No translation available.
KF511363 Genomic DNA. No translation available.
KF511364 Genomic DNA. No translation available.
RefSeqiNP_001129602.1. NM_001136130.2.
UniGeneiHs.434980.

Genome annotation databases

EnsembliENST00000439274; ENSP00000398879; ENSG00000142192.
GeneIDi351.
KEGGihsa:351.
UCSCiuc011ach.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001439 Genomic DNA. No translation available.
AP001440 Genomic DNA. No translation available.
AP001441 Genomic DNA. No translation available.
AP001442 Genomic DNA. No translation available.
AP001443 Genomic DNA. No translation available.
KC877827 Genomic DNA. No translation available.
KC877829 Genomic DNA. No translation available.
KC877830 Genomic DNA. No translation available.
KC877833 Genomic DNA. No translation available.
KC877835 Genomic DNA. No translation available.
KC877836 Genomic DNA. No translation available.
KC877837 Genomic DNA. No translation available.
KC877838 Genomic DNA. No translation available.
KC877840 Genomic DNA. No translation available.
KC877846 Genomic DNA. No translation available.
KC877849 Genomic DNA. No translation available.
KF454891 Genomic DNA. No translation available.
KF457122 Genomic DNA. No translation available.
KF457123 Genomic DNA. No translation available.
KF457130 Genomic DNA. No translation available.
KF457131 Genomic DNA. No translation available.
KF457132 Genomic DNA. No translation available.
KF457133 Genomic DNA. No translation available.
KF457134 Genomic DNA. No translation available.
KF457140 Genomic DNA. No translation available.
KF510514 Genomic DNA. No translation available.
KF510515 Genomic DNA. No translation available.
KF510516 Genomic DNA. No translation available.
KF510517 Genomic DNA. No translation available.
KF510518 Genomic DNA. No translation available.
KF510519 Genomic DNA. No translation available.
KF510520 Genomic DNA. No translation available.
KF510521 Genomic DNA. No translation available.
KF510523 Genomic DNA. No translation available.
KF510525 Genomic DNA. No translation available.
KF510526 Genomic DNA. No translation available.
KF511359 Genomic DNA. No translation available.
KF511362 Genomic DNA. No translation available.
KF511363 Genomic DNA. No translation available.
KF511364 Genomic DNA. No translation available.
RefSeqi NP_001129602.1. NM_001136130.2.
UniGenei Hs.434980.

3D structure databases

ProteinModelPortali E9PG40.
SMRi E9PG40. Positions 19-136, 231-286, 315-510, 627-672, 685-712.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi E9PG40.

Proteomic databases

PRIDEi E9PG40.

Protocols and materials databases

DNASUi 351.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000439274 ; ENSP00000398879 ; ENSG00000142192 .
GeneIDi 351.
KEGGi hsa:351.
UCSCi uc011ach.2. human.

Organism-specific databases

CTDi 351.
HGNCi HGNC:620. APP.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000063252.
KOi K04520.

Miscellaneous databases

ChiTaRSi APP. human.
GenomeRNAii 351.
NextBioi 1445.

Gene expression databases

Bgeei E9PG40.
ExpressionAtlasi E9PG40. baseline and differential.

Family and domain databases

Gene3Di 3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProi IPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view ]
PANTHERi PTHR23103:SF7. PTHR23103:SF7. 1 hit.
Pfami PF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view ]
PRINTSi PR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTi SM00131. KU. 1 hit.
[Graphical view ]
SUPFAMi SSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEi PS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 21."
    Chromosome 21 mapping and sequencing consortium
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PG40_HUMAN
AccessioniPrimary (citable) accession number: E9PG40
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3