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E9PG40

- E9PG40_HUMAN

UniProt

E9PG40 - E9PG40_HUMAN

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Protein
Submitted name: Gamma-secretase C-terminal fragment 59
Gene
APP
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. heparin binding Source: InterPro
  2. serine-type endopeptidase inhibitor activity Source: InterPro
  3. transition metal ion binding Source: InterPro

GO - Biological processi

  1. nervous system development Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Gamma-secretase C-terminal fragment 59Imported
Gene namesi
Name:APPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:620. APP.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. integral component of membrane Source: InterPro
  3. intracellular membrane-bounded organelle Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9PG40.

Expressioni

Gene expression databases

ArrayExpressiE9PG40.
BgeeiE9PG40.

Structurei

3D structure databases

ProteinModelPortaliE9PG40.
SMRiE9PG40. Positions 19-136, 231-286, 315-510, 627-672, 685-712.

Family & Domainsi

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.UniRule annotation

Phylogenomic databases

KOiK04520.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTiSM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PG40-1 [UniParc]FASTAAdd to Basket

« Hide

MLPGLALLLL AAWTARALEV YPELQITNVV EANQPVTIQN WCKRGRKQCK    50
THPHFVIPYR CLVGEFVSDA LLVPDKCKFL HQERMDVCET HLHWHTVAKE 100
TCSEKSTNLH DYGMLLPCGI DKFRGVEFVC CPLAEESDNV DSADAEEDDS 150
DVWWGGADTD YADGSEDKVV EVAEEEEVAE VEEEEADDDE DDEDGDEVEE 200
EAEEPYEEAT ERTTSIATTT TTTTESVEEV VREVCSEQAE TGPCRAMISR 250
WYFDVTEGKC APFFYGGCGG NRNNFDTEEY CMAVCGSAMS QSLLKTTQEP 300
LARDPVKLPT TAASTPDAVD KYLETPGDEN EHAHFQKAKE RLEAKHRERM 350
SQVMREWEEA ERQAKNLPKA DKKAVIQHFQ EKVESLEQEA ANERQQLVET 400
HMARVEAMLN DRRRLALENY ITALQAVPPR PRHVFNMLKK YVRAEQKDRQ 450
HTLKHFEHVR MVDPKKAAQI RSQVMTHLRV IYERMNQSLS LLYNVPAVAE 500
EIQDEVDELL QKEQNYSDDV LANMISEPRI SYGNDALMPS LTETKTTVEL 550
LPVNGEFSLD DLQPWHSFGA DSVPANTENE VEPVDARPAA DRGLTTRPGS 600
GLTNIKTEEI SEVKMDAEFR HDSGYEVHHQ KLVFFAEDVG SNKGAIIGLM 650
VGGVVIATVI VITLVMLKKK QYTSIHHGVV EVDAAVTPEE RHLSKMQQNG 700
YENPTYKFFE QMQN 714
Length:714
Mass (Da):80,833
Last modified:April 5, 2011 - v1
Checksum:i68CC52E6F29B777B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001439 Genomic DNA. No translation available.
AP001440 Genomic DNA. No translation available.
AP001441 Genomic DNA. No translation available.
AP001442 Genomic DNA. No translation available.
AP001443 Genomic DNA. No translation available.
RefSeqiNP_001129602.1. NM_001136130.2.
UniGeneiHs.434980.

Genome annotation databases

EnsembliENST00000439274; ENSP00000398879; ENSG00000142192.
GeneIDi351.
KEGGihsa:351.
UCSCiuc011ach.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001439 Genomic DNA. No translation available.
AP001440 Genomic DNA. No translation available.
AP001441 Genomic DNA. No translation available.
AP001442 Genomic DNA. No translation available.
AP001443 Genomic DNA. No translation available.
RefSeqi NP_001129602.1. NM_001136130.2.
UniGenei Hs.434980.

3D structure databases

ProteinModelPortali E9PG40.
SMRi E9PG40. Positions 19-136, 231-286, 315-510, 627-672, 685-712.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9PG40.

Protocols and materials databases

DNASUi 351.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000439274 ; ENSP00000398879 ; ENSG00000142192 .
GeneIDi 351.
KEGGi hsa:351.
UCSCi uc011ach.2. human.

Organism-specific databases

CTDi 351.
HGNCi HGNC:620. APP.
GenAtlasi Search...

Phylogenomic databases

KOi K04520.

Miscellaneous databases

ChiTaRSi app. human.
GenomeRNAii 351.
NextBioi 1445.

Gene expression databases

ArrayExpressi E9PG40.
Bgeei E9PG40.

Family and domain databases

Gene3Di 3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProi IPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view ]
PANTHERi PTHR23103:SF7. PTHR23103:SF7. 1 hit.
Pfami PF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view ]
PRINTSi PR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTi SM00131. KU. 1 hit.
[Graphical view ]
SUPFAMi SSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEi PS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 21."
    Chromosome 21 mapping and sequencing consortium
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PG40_HUMAN
AccessioniPrimary (citable) accession number: E9PG40
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi