Skip Header

Contribute Send feedback
Read comments (?) or add your own

E9PG40 (E9PG40_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesSubmitted name:
Gamma-secretase C-terminal fragment 59 Ensembl ENSP00000398879
Gene names
Name:APP Ensembl ENSP00000398879
OrganismHomo sapiens (Human) [Reference proteome] Ensembl ENSP00000398879
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length714 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 BPTI/Kunitz inhibitor domain. RuleBase RU000413

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000398879

Sequences

Sequence LengthMass (Da)Tools
E9PG40 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 68CC52E6F29B777B

FASTA71480,833
        10         20         30         40         50         60 
MLPGLALLLL AAWTARALEV YPELQITNVV EANQPVTIQN WCKRGRKQCK THPHFVIPYR 

        70         80         90        100        110        120 
CLVGEFVSDA LLVPDKCKFL HQERMDVCET HLHWHTVAKE TCSEKSTNLH DYGMLLPCGI 

       130        140        150        160        170        180 
DKFRGVEFVC CPLAEESDNV DSADAEEDDS DVWWGGADTD YADGSEDKVV EVAEEEEVAE 

       190        200        210        220        230        240 
VEEEEADDDE DDEDGDEVEE EAEEPYEEAT ERTTSIATTT TTTTESVEEV VREVCSEQAE 

       250        260        270        280        290        300 
TGPCRAMISR WYFDVTEGKC APFFYGGCGG NRNNFDTEEY CMAVCGSAMS QSLLKTTQEP 

       310        320        330        340        350        360 
LARDPVKLPT TAASTPDAVD KYLETPGDEN EHAHFQKAKE RLEAKHRERM SQVMREWEEA 

       370        380        390        400        410        420 
ERQAKNLPKA DKKAVIQHFQ EKVESLEQEA ANERQQLVET HMARVEAMLN DRRRLALENY 

       430        440        450        460        470        480 
ITALQAVPPR PRHVFNMLKK YVRAEQKDRQ HTLKHFEHVR MVDPKKAAQI RSQVMTHLRV 

       490        500        510        520        530        540 
IYERMNQSLS LLYNVPAVAE EIQDEVDELL QKEQNYSDDV LANMISEPRI SYGNDALMPS 

       550        560        570        580        590        600 
LTETKTTVEL LPVNGEFSLD DLQPWHSFGA DSVPANTENE VEPVDARPAA DRGLTTRPGS 

       610        620        630        640        650        660 
GLTNIKTEEI SEVKMDAEFR HDSGYEVHHQ KLVFFAEDVG SNKGAIIGLM VGGVVIATVI 

       670        680        690        700        710 
VITLVMLKKK QYTSIHHGVV EVDAAVTPEE RHLSKMQQNG YENPTYKFFE QMQN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP001439 Genomic DNA. No translation available.
AP001440 Genomic DNA. No translation available.
AP001441 Genomic DNA. No translation available.
AP001442 Genomic DNA. No translation available.
AP001443 Genomic DNA. No translation available.
IPIIPI00914602.
RefSeqNP_001129602.1. NM_001136130.2.
UniGeneHs.434980.

3D structure databases

ProteinModelPortalE9PG40.
SMRE9PG40. Positions 19-136, 231-286, 315-510, 627-672, 685-712.
ModBaseSearch...

Proteomic databases

PRIDEE9PG40.

Protocols and materials databases

DNASU351.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000439274; ENSP00000398879; ENSG00000142192.
GeneID351.
KEGGhsa:351.
UCSCuc011ach.2. human.

Organism-specific databases

CTD351.
HGNCHGNC:620. APP.
GenAtlasSearch...

Phylogenomic databases

KOK04520.

Gene expression databases

ArrayExpressE9PG40.
BgeeE9PG40.

Family and domain databases

Gene3D3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR019543. APP_amyloid_C.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTSM00131. KU. 1 hit.
[Graphical view]
SUPFAMSSF56491. A4_extra. 1 hit.
SSF89811. Amyloid_glyco_Cu-bd. 1 hit.
SSF57362. Prot_inh_Kunz-m. 1 hit.
SSF109843. SSF109843. 1 hit.
PROSITEPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSapp. human.
GenomeRNAi351.
NextBio1445.

Entry information

Entry nameE9PG40_HUMAN
AccessionPrimary (citable) accession number: E9PG40
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info