Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Rho guanine nucleotide exchange factor 3

Gene

ARHGEF3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 3Imported
Gene namesi
Name:ARHGEF3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163947.11
HGNCiHGNC:683 ARHGEF3

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163947

PTM / Processingi

Proteomic databases

MaxQBiE9PG37
PeptideAtlasiE9PG37
PRIDEiE9PG37

Expressioni

Gene expression databases

BgeeiENSG00000163947
ExpressionAtlasiE9PG37 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9PG37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 310DHInterPro annotationAdd BLAST183
Domaini297 – 455PHInterPro annotationAdd BLAST159

Phylogenomic databases

eggNOGiKOG4305 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00760000119193

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.101 hit
2.30.29.301 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

E9PG37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSERPMVWC CLFVRSQRKR KQSTQDEDAV SLCSLDISEP SNKRVKPLSR
60 70 80 90 100
VTSLANLIPP VKATPLKRFS QTLQRSISFR SESRPDILAP RPWSRNAAPS
110 120 130 140 150
STKRRDSKLW SETFDVCVNQ MLTSKEIKRQ EAIFELSQGE EDLIEDLKLA
160 170 180 190 200
KKAYHDPMLK LSIMTEQELN QIFGTLDSLI PLHEELLSQL RDVRKPDGST
210 220 230 240 250
EHVGPILVGW LPCLSSYDSY CSNQVAAKAL LDHKKQDHRV QDFLQRCLES
260 270 280 290 300
PFSRKLDLWN FLDIPRSRLV KYPLLLREIL RHTPNDNPDQ QHLEEAINII
310 320 330 340 350
QGIVAEINTK TGESECRYYK ERLLYLEEGQ KDSLIDSSRV LCCHGELKNN
360 370 380 390 400
RGVKLHVFLF QEVLVITRAV THNEQLCYQL YRQPIPVKDL LLEDLQDGEV
410 420 430 440 450
RLGGSLRGAF SNNERIKNFF RVSFKNGSQS QTHSLQANDT FNKQQWLNCI
460 470 480 490 500
RQAKETVLCA AGQAGVLDSE GSFLNPTTGS RELQGETKLE QMDQSDSESD
510 520 530
CSMDTSEVSL DCERMEQTDS SCGNSRHGES NV
Length:532
Mass (Da):60,790
Last modified:April 5, 2011 - v1
Checksum:iA8A32FEA5303B6D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097358 Genomic DNA No translation available.
AC099327 Genomic DNA No translation available.
AC099559 Genomic DNA No translation available.
AC099781 Genomic DNA No translation available.
RefSeqiNP_001276627.1, NM_001289698.1
UniGeneiHs.476402

Genome annotation databases

EnsembliENST00000496106; ENSP00000420420; ENSG00000163947
GeneIDi50650
UCSCiuc011bew.3 human

Similar proteinsi

Entry informationi

Entry nameiE9PG37_HUMAN
AccessioniPrimary (citable) accession number: E9PG37
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported