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E9PG37

- E9PG37_HUMAN

UniProt

E9PG37 - E9PG37_HUMAN

Protein
Submitted name:

Rho guanine nucleotide exchange factor 3

Gene

ARHGEF3

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factorSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Rho guanine nucleotide exchange factor 3Imported
    Gene namesi
    Name:ARHGEF3Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:683. ARHGEF3.

    Expressioni

    Gene expression databases

    ArrayExpressiE9PG37.
    BgeeiE9PG37.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PG37.
    SMRiE9PG37. Positions 120-455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PH domain.
    Contains DH (DBL-homology) domain.SAAS annotation
    Contains PH domain.SAAS annotation

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015721. RhoGEF-like.
    [Graphical view]
    PANTHERiPTHR22825. PTHR22825. 1 hit.
    PfamiPF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    PROSITEiPS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PG37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSERPMVWC CLFVRSQRKR KQSTQDEDAV SLCSLDISEP SNKRVKPLSR    50
    VTSLANLIPP VKATPLKRFS QTLQRSISFR SESRPDILAP RPWSRNAAPS 100
    STKRRDSKLW SETFDVCVNQ MLTSKEIKRQ EAIFELSQGE EDLIEDLKLA 150
    KKAYHDPMLK LSIMTEQELN QIFGTLDSLI PLHEELLSQL RDVRKPDGST 200
    EHVGPILVGW LPCLSSYDSY CSNQVAAKAL LDHKKQDHRV QDFLQRCLES 250
    PFSRKLDLWN FLDIPRSRLV KYPLLLREIL RHTPNDNPDQ QHLEEAINII 300
    QGIVAEINTK TGESECRYYK ERLLYLEEGQ KDSLIDSSRV LCCHGELKNN 350
    RGVKLHVFLF QEVLVITRAV THNEQLCYQL YRQPIPVKDL LLEDLQDGEV 400
    RLGGSLRGAF SNNERIKNFF RVSFKNGSQS QTHSLQANDT FNKQQWLNCI 450
    RQAKETVLCA AGQAGVLDSE GSFLNPTTGS RELQGETKLE QMDQSDSESD 500
    CSMDTSEVSL DCERMEQTDS SCGNSRHGES NV 532
    Length:532
    Mass (Da):60,790
    Last modified:April 5, 2011 - v1
    Checksum:iA8A32FEA5303B6D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC097358 Genomic DNA. No translation available.
    AC099327 Genomic DNA. No translation available.
    AC099559 Genomic DNA. No translation available.
    AC099781 Genomic DNA. No translation available.
    RefSeqiNP_001276627.1. NM_001289698.1.
    UniGeneiHs.476402.

    Genome annotation databases

    EnsembliENST00000496106; ENSP00000420420; ENSG00000163947.
    GeneIDi50650.
    KEGGihsa:50650.
    UCSCiuc011bew.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC097358 Genomic DNA. No translation available.
    AC099327 Genomic DNA. No translation available.
    AC099559 Genomic DNA. No translation available.
    AC099781 Genomic DNA. No translation available.
    RefSeqi NP_001276627.1. NM_001289698.1.
    UniGenei Hs.476402.

    3D structure databases

    ProteinModelPortali E9PG37.
    SMRi E9PG37. Positions 120-455.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000496106 ; ENSP00000420420 ; ENSG00000163947 .
    GeneIDi 50650.
    KEGGi hsa:50650.
    UCSCi uc011bew.1. human.

    Organism-specific databases

    CTDi 50650.
    HGNCi HGNC:683. ARHGEF3.
    GenAtlasi Search...

    Miscellaneous databases

    ChiTaRSi ARHGEF3. human.
    GenomeRNAii 50650.
    NextBioi 35501916.

    Gene expression databases

    ArrayExpressi E9PG37.
    Bgeei E9PG37.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015721. RhoGEF-like.
    [Graphical view ]
    PANTHERi PTHR22825. PTHR22825. 1 hit.
    Pfami PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    PROSITEi PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE9PG37_HUMAN
    AccessioniPrimary (citable) accession number: E9PG37
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3