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Protein
Submitted name:

Rho guanine nucleotide exchange factor 3

Gene

ARHGEF3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 3Imported
Gene namesi
Name:ARHGEF3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:683. ARHGEF3.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163947.

PTM / Processingi

Proteomic databases

MaxQBiE9PG37.
PaxDbiE9PG37.
PeptideAtlasiE9PG37.
PRIDEiE9PG37.

Expressioni

Gene expression databases

BgeeiENSG00000163947.
ExpressionAtlasiE9PG37. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PG37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 310DH (DBL-homology)InterPro annotationAdd BLAST183
Domaini297 – 455PHInterPro annotationAdd BLAST159

Phylogenomic databases

eggNOGiKOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000119193.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
PfamiView protein in Pfam
PF00621. RhoGEF. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PG37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSERPMVWC CLFVRSQRKR KQSTQDEDAV SLCSLDISEP SNKRVKPLSR
60 70 80 90 100
VTSLANLIPP VKATPLKRFS QTLQRSISFR SESRPDILAP RPWSRNAAPS
110 120 130 140 150
STKRRDSKLW SETFDVCVNQ MLTSKEIKRQ EAIFELSQGE EDLIEDLKLA
160 170 180 190 200
KKAYHDPMLK LSIMTEQELN QIFGTLDSLI PLHEELLSQL RDVRKPDGST
210 220 230 240 250
EHVGPILVGW LPCLSSYDSY CSNQVAAKAL LDHKKQDHRV QDFLQRCLES
260 270 280 290 300
PFSRKLDLWN FLDIPRSRLV KYPLLLREIL RHTPNDNPDQ QHLEEAINII
310 320 330 340 350
QGIVAEINTK TGESECRYYK ERLLYLEEGQ KDSLIDSSRV LCCHGELKNN
360 370 380 390 400
RGVKLHVFLF QEVLVITRAV THNEQLCYQL YRQPIPVKDL LLEDLQDGEV
410 420 430 440 450
RLGGSLRGAF SNNERIKNFF RVSFKNGSQS QTHSLQANDT FNKQQWLNCI
460 470 480 490 500
RQAKETVLCA AGQAGVLDSE GSFLNPTTGS RELQGETKLE QMDQSDSESD
510 520 530
CSMDTSEVSL DCERMEQTDS SCGNSRHGES NV
Length:532
Mass (Da):60,790
Last modified:April 5, 2011 - v1
Checksum:iA8A32FEA5303B6D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097358 Genomic DNA. No translation available.
AC099327 Genomic DNA. No translation available.
AC099559 Genomic DNA. No translation available.
AC099781 Genomic DNA. No translation available.
RefSeqiNP_001276627.1. NM_001289698.1.
UniGeneiHs.476402.

Genome annotation databases

EnsembliENST00000496106; ENSP00000420420; ENSG00000163947.
GeneIDi50650.
UCSCiuc011bew.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiE9PG37_HUMAN
AccessioniPrimary (citable) accession number: E9PG37
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 5, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported