Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

AP-2 complex subunit mu

Gene

AP2M1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei366Phosphatidylinositol lipid headgroupUniRule annotation1
Binding sitei368Phosphatidylinositol lipid headgroupUniRule annotation1
Binding sitei370Phosphatidylinositol lipid headgroupUniRule annotation1
Binding sitei379Phosphatidylinositol lipid headgroupUniRule annotation1
Binding sitei381Phosphatidylinositol lipid headgroupUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transportSAAS annotation, Transport
LigandLipid-bindingUniRule annotation

Enzyme and pathway databases

SignaLinkiE9PFW3.

Names & Taxonomyi

Protein namesi
Submitted name:
AP-2 complex subunit muImported
Gene namesi
Name:AP2M1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000161203.13.
HGNCiHGNC:564. AP2M1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161203.

PTM / Processingi

Proteomic databases

EPDiE9PFW3.
MaxQBiE9PFW3.
PeptideAtlasiE9PFW3.
PRIDEiE9PFW3.

Expressioni

Gene expression databases

BgeeiENSG00000161203.
ExpressionAtlasiE9PFW3. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9PFW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 459MHDInterPro annotationAdd BLAST265

Sequence similaritiesi

Belongs to the adaptor complexes medium subunit family.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000062779.
OMAiSWRKADV.
OrthoDBiEOG091G06XI.
PhylomeDBiE9PFW3.

Family and domain databases

InterProiView protein in InterPro
IPR036168. AP2_Mu_C_sf.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom_sf.
IPR028565. MHD.
PfamiView protein in Pfam
PF00928. Adap_comp_sub. 1 hit.
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiView protein in PROSITE
PS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PFW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGGLFIYNH KGEVLISRVY RDDIGSRQAA DSAVFSSSGP FPGEWLEANR
60 70 80 90 100
RNAVDAFRVN VIHARQQVRS PVTNIARTSF FHVKRSNIWL AAVTKQNVNA
110 120 130 140 150
AMVFEFLYKM CDVMAAYFGK ISEENIKNNF VLIYELLDEI LDFGYPQNSE
160 170 180 190 200
TGALKTFITQ QGIKSQHQTK EEQSQITSQV TGQIGWRREG IKYRRNELFL
210 220 230 240 250
DVLESVNLLM SPQGQVLSAH VSGRVVMKSY LSGMPECKFG MNDKIVIEKQ
260 270 280 290 300
GKGTADETSK SGKQSIAIDD CTFHQCVRLS KFDSERSISF IPPDGEFELM
310 320 330 340 350
RYRTTKDIIL PFRVIPLVRE VGRTKLEVKV VIKSNFKPSL LAQKIEVRIP
360 370 380 390 400
TPLNTSGVQV ICMKGKAKYK ASENAIVWKI KRMAGMKESQ ISAEIELLPT
410 420 430 440 450
NDKKKWARPP ISMNFEVPFA PSGLKVRYLK VFEPKLNYSD HDVIKWVRYI
460
GRSGIYETRC
Length:460
Mass (Da):52,304
Last modified:April 5, 2011 - v1
Checksum:iB693E3B0195DAC5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131235 Genomic DNA. No translation available.
RefSeqiNP_001298127.1. NM_001311198.1.
UniGeneiHs.518460.

Genome annotation databases

EnsembliENST00000411763; ENSP00000403362; ENSG00000161203.
GeneIDi1173.
UCSCiuc062qrq.1. human.

Similar proteinsi

Entry informationi

Entry nameiE9PFW3_HUMAN
AccessioniPrimary (citable) accession number: E9PFW3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 22, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported