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Protein
Submitted name:

Adenomatous polyposis coli protein

Gene

APC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiE9PFT7

Names & Taxonomyi

Protein namesi
Submitted name:
Adenomatous polyposis coli proteinImported
Gene namesi
Name:APCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000134982.16
HGNCiHGNC:583 APC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134982

PTM / Processingi

Proteomic databases

PeptideAtlasiE9PFT7
PRIDEiE9PFT7

Expressioni

Gene expression databases

BgeeiENSG00000134982
ExpressionAtlasiE9PFT7 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9PFT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 55APC_N_CCInterPro annotationAdd BLAST52
Repeati660 – 702ARMPROSITE-ProRule annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili6 – 54Sequence analysisAdd BLAST49
Coiled coili134 – 168Sequence analysisAdd BLAST35
Coiled coili207 – 227Sequence analysisAdd BLAST21
Coiled coili530 – 550Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2122 Eukaryota
ENOG410XR2V LUCA
GeneTreeiENSGT00530000063749

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR026836 APC
IPR009240 APC_15aa_rpt
IPR026831 APC_dom
IPR026818 Apc_fam
IPR032038 APC_N
IPR036149 APC_N_sf
IPR009223 APC_rpt
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
PANTHERiPTHR12607 PTHR12607, 1 hit
PTHR12607:SF11 PTHR12607:SF11, 1 hit
PfamiView protein in Pfam
PF05972 APC_15aa, 4 hits
PF16689 APC_N_CC, 1 hit
PF05923 APC_r, 1 hit
PF00514 Arm, 2 hits
SMARTiView protein in SMART
SM00185 ARM, 7 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF58050 SSF58050, 1 hit
SSF82931 SSF82931, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

Sequencei

Sequence statusi: Fragment.

E9PFT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ
60 70 80 90 100
LQGSIEDEAM ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE
110 120 130 140 150
GSVSSRSGEC SPVPMGSFPR RGFVNGSRES TGYLEELEKE RSLLLADLDK
160 170 180 190 200
EEKEKDWYYA QLQNLTKRID SLPLTENFSL QTDMTRRQLE YEARQIRVAM
210 220 230 240 250
EEQLGTCQDM EKRAQRRIAR IQQIEKDILR IRQLLQSQAT EAERSSQNKH
260 270 280 290 300
ETGSHDAERQ NEGQGVGEIN MATSGNGQGS TTRMDHETAS VLSSSSTHSA
310 320 330 340 350
PRRLTSHLGT KVEMVYSLLS MLGTHDKDDM SRTLLAMSSS QDSCISMRQS
360 370 380 390 400
GCLPLLIQLL HGNDKDSVLL GNSRGSKEAR ARASAALHNI IHSQPDDKRG
410 420 430 440 450
RREIRVLHLL EQIRAYCETC WEWQEAHEPG MDQDKNPMPA PVEHQICPAV
460 470 480 490 500
CVLMKLSFDE EHRHAMNELG GLQAIAELLQ VDCEMYGLTN DHYSITLRRY
510 520 530 540 550
AGMALTNLTF GDVANKATLC SMKGCMRALV AQLKSESEDL QQVIASVLRN
560 570 580 590 600
LSWRADVNSK KTLREVGSVK ALMECALEVK KESTLKSVLS ALWNLSAHCT
610 620 630 640 650
ENKADICAVD GALAFLVGTL TYRSQTNTLA IIESGGGILR NVSSLIATNE
660 670 680 690 700
DHRQILRENN CLQTLLQHLK SHSLTIVSNA CGTLWNLSAR NPKDQEALWD
710 720 730 740 750
MGAVSMLKNL IHSKHKMIAM GSAAALRNLM ANRPAKYKDA NIMSPGSSLP
760 770 780 790 800
SLHVRKQKAL EAELDAQHLS ETFDNIDNLS PKASHRSKQR HKQSLYGDYV
810 820 830 840 850
FDTNRHDDNR SDNFNTGNMT VLSPYLNTTV LPSSSSSRGS LDSSRSEKDR
860 870 880 890 900
SLERERGIGL GNYHPATENP GTSSKRGLQI STTAAQIAKV MEEVSAIHTS
910 920 930 940 950
QEDRSSGSTT ELHCVTDERN ALRRSSAAHT HSNTYNFTKS ENSNRTCSMP
960 970 980 990 1000
YAKLEYKRSS NDSLNSVSSS DGYGKRGQMK PSIESYSEDD ESKFCSYGQY
1010 1020 1030 1040 1050
PADLAHKIHS ANHMDDNDGE LDTPINYSLK YSDEQLNSGR QSPSQNERWA
1060 1070 1080 1090 1100
RPKHIIEDEI KQSEQRQSRN QSTTYPVYTE STDDKHLKFQ PHFGQQECVS
1110 1120 1130 1140 1150
PYRSRGANGS ETNRVGSNHG INQNVSQSLC QEDDYEDDKP TNYSERYSEE
1160 1170 1180 1190 1200
EQHEEEERPT NYSIKYNEEK RHVDQPIDYS LKYATDIPSS QKQSFSFSKS
1210 1220 1230 1240 1250
SSGQSSKTEH MSSSSENTST PSSNAKRQNQ LHPSSAQSRS GQPQKAATCK
1260 1270 1280 1290 1300
VSSINQETIQ TYCVEDTPIC FSRCSSLSSL SSAEDEIGCN QTTQEADSAN

TLQI
Length:1,304
Mass (Da):145,688
Last modified:October 5, 2016 - v8
Checksum:i3C44BED5CCEFA1B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1304Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008575 Genomic DNA No translation available.
AC136500 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000512211; ENSP00000423828; ENSG00000134982
UCSCiuc063gap.1 human

Similar proteinsi

Entry informationi

Entry nameiE9PFT7_HUMAN
AccessioniPrimary (citable) accession number: E9PFT7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 5, 2016
Last modified: May 23, 2018
This is version 65 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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