ID   E9PF59_HUMAN            Unreviewed;       801 AA.
AC   E9PF59;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=Dipeptidyl aminopeptidase-like protein 6 {ECO:0000256|ARBA:ARBA00040948};
DE   AltName: Full=Dipeptidyl peptidase 6 {ECO:0000256|ARBA:ARBA00042016};
DE   AltName: Full=Dipeptidyl peptidase VI {ECO:0000256|ARBA:ARBA00041991};
GN   Name=DPP6 {ECO:0000313|Ensembl:ENSP00000385578.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000385578.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000385578.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000385578.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC005588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC099341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC142230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEKP01160869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001034439.1; NM_001039350.2.
DR   AlphaFoldDB; E9PF59; -.
DR   SMR; E9PF59; -.
DR   ESTHER; human-DPP6; DPP4N_Peptidase_S9.
DR   MEROPS; S09.973; -.
DR   MassIVE; E9PF59; -.
DR   PeptideAtlas; E9PF59; -.
DR   ProteomicsDB; 20034; -.
DR   Antibodypedia; 33071; 267 antibodies from 27 providers.
DR   DNASU; 1804; -.
DR   Ensembl; ENST00000404039.5; ENSP00000385578.1; ENSG00000130226.18.
DR   GeneID; 1804; -.
DR   UCSC; uc003wli.4; human.
DR   CTD; 1804; -.
DR   HGNC; HGNC:3010; DPP6.
DR   VEuPathDB; HostDB:ENSG00000130226; -.
DR   GeneTree; ENSGT00940000156280; -.
DR   OrthoDB; 2876738at2759; -.
DR   BioGRID-ORCS; 1804; 13 hits in 392 CRISPR screens.
DR   ChiTaRS; DPP6; human.
DR   GenomeRNAi; 1804; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000130226; Expressed in middle temporal gyrus and 162 other cell types or tissues.
DR   ExpressionAtlas; E9PF59; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF20; DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR   Genevisible; E9PF59; HS.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|MaxQB:E9PF59,
KW   ECO:0007829|PeptideAtlas:E9PF59};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        32..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          131..497
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          578..784
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   801 AA;  91246 MW;  5B272181F6CD6391 CRC64;
     MKEKAMIKTA KMQGNVMELV GSNPPQRNWK GIAIALLVIL VICSLIVTSV ILLTPAEDNS
     LSQKKKVTVE DLFSEDFKIH DPEAKWISDT EFIYREQKGT VRLWNVETNT STVLIEGKKI
     ESLRAIRYEI SPDREYALFS YNVEPIYQHS YTGYYVLSKI PHGDPQSLDP PEVSNAKLQY
     AGWGPKGQQL IFIFENNIYY CAHVGKQAIR VVSTGKEGVI YNGLSDWLYE EEILKTHIAH
     WWSPDGTRLA YAAINDSRVP IMELPTYTGS IYPTVKPYHY PKAGSENPSI SLHVIGLNGP
     THDLEMMPPD DPRMREYYIT MVKWATSTKV AVTWLNRAQN VSILTLCDAT TGVCTKKHED
     ESEAWLHRQN EEPVFSKDGR KFFFIRAIPQ GGRGKFYHIT VSSSQPNSSN DNIQSITSGD
     WDVTKILAYD EKGNKIYFLS TEDLPRRRQL YSANTVGNFN RQCLSCDLVE NCTYFSASFS
     HSMDFFLLKC EGPGVPMVTV HNTTDKKKMF DLETNEHVKK AINDRQMPKV EYRDIEIDDY
     NLPMQILKPA TFTDTTHYPL LLVVDGTPGS QSVAEKFEVS WETVMVSSHG AVVVKCDGRG
     SGFQGTKLLH EVRRRLGLLE EKDQMEAVRT MLKEQYIDRT RVAVFGKDYG GYLSTYILPA
     KGENQGQTFT CGSALSPITD FKLYASAFSE RYLGLHGLDN RAYEMTKVAH RVSALEEQQF
     LIIHPTADEK IHFQHTAELI TQLIRGKANY SLQIYPDESH YFTSSSLKQH LYRSIINFFV
     ECFRIQDKLL TVTAKEDEEE D
//