Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Gene

HADH

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77Coenzyme AUniRule annotation1
Binding sitei84Coenzyme AUniRule annotation1
Binding sitei153Coenzyme AUniRule annotation1
Sitei174Important for catalytic activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialImported
Gene namesi
Name:HADHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4799. HADH.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138796.

PTM / Processingi

Proteomic databases

EPDiE9PF18.
MaxQBiE9PF18.
PeptideAtlasiE9PF18.
PRIDEiE9PF18.

Expressioni

Gene expression databases

BgeeiENSG00000138796.
ExpressionAtlasiE9PF18. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PF18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 2183HCDH_NInterPro annotationAdd BLAST171
Domaini220 – 3173HCDHInterPro annotationAdd BLAST98

Phylogenomic databases

GeneTreeiENSGT00720000108673.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PF18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCRTALGVTT LQDLGVCWRK EHDPAEMLRV GRAELGGWKP SWEAIVKEVA
60 70 80 90 100
AATGHTVVLV DQTEDILAKS KKGIEESLRK VAKKKFAENL KAGDEFVEKT
110 120 130 140 150
LSTIATSTDA ASVVHSTDLV VEAIVENLKV KNELFKRLDK FAAEHTIFAS
160 170 180 190 200
NTSSLQITSI ANATTRQDRF AGLHFFNPVP VMKLVEVIKT PMTSQKTFES
210 220 230 240 250
LVDFSKALGK HPVSCKDTPG FIVNRLLVPY LMEAIRLYER GDASKEDIDT
260 270 280 290 300
AMKLGAGYPM GPFELLDYVG LDTTKFIVDG WHEMDAENPL HQPSPSLNKL
310
VAENKFGKKT GEGFYKYK
Length:318
Mass (Da):35,237
Last modified:April 5, 2011 - v1
Checksum:i7F86567AD18096E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114733 Genomic DNA. No translation available.
AC118062 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000505878; ENSP00000425952; ENSG00000138796.
ENST00000626637; ENSP00000486771; ENSG00000138796.
UCSCiuc003hyr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114733 Genomic DNA. No translation available.
AC118062 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PF18.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiE9PF18.
MaxQBiE9PF18.
PeptideAtlasiE9PF18.
PRIDEiE9PF18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000505878; ENSP00000425952; ENSG00000138796.
ENST00000626637; ENSP00000486771; ENSG00000138796.
UCSCiuc003hyr.4. human.

Organism-specific databases

CTDi3033.
HGNCiHGNC:4799. HADH.
OpenTargetsiENSG00000138796.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00720000108673.

Miscellaneous databases

ChiTaRSiHADH. human.
GenomeRNAii3033.

Gene expression databases

BgeeiENSG00000138796.
ExpressionAtlasiE9PF18. baseline and differential.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PF18_HUMAN
AccessioniPrimary (citable) accession number: E9PF18
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.