SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

E9PEV0

- E9PEV0_HUMAN

UniProt

E9PEV0 - E9PEV0_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Gamma-secretase C-terminal fragment 59
Gene
APP
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. heparin binding Source: InterPro
  2. transition metal ion binding Source: InterPro

GO - Biological processi

  1. nervous system development Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Gamma-secretase C-terminal fragment 59Imported
Gene namesi
Name:APPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:620. APP.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. integral component of membrane Source: InterPro
  3. intracellular membrane-bounded organelle Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9PEV0.

Expressioni

Gene expression databases

ArrayExpressiE9PEV0.
BgeeiE9PEV0.

Structurei

3D structure databases

ProteinModelPortaliE9PEV0.
SMRiE9PEV0. Positions 1-157, 275-457, 573-618, 631-658.

Family & Domainsi

Phylogenomic databases

KOiK04520.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00204. BETAAMYLOID.
SMARTiSM00006. A4_EXTRA. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PEV0-1 [UniParc]FASTAAdd to Basket

« Hide

MFCGRLNMHM NVQNGKWDSD PSGTKTCIDT KEGILQYCQE VYPELQITNV    50
VEANQPVTIQ NWCKRGRKQC KTHPHFVIPY RCLVGEFVSD ALLVPDKCKF 100
LHQERMDVCE THLHWHTVAK ETCSEKSTNL HDYGMLLPCG IDKFRGVEFV 150
CCPLAEESDN VDSADAEEDD SDVWWGGADT DYADGSEDKV VEVAEEEEVA 200
EVEEEEADDD EDDEDGDEVE EEAEEPYEEA TERTTSIATT TTTTTESVEE 250
VVRVPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM 300
REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR 350
VEAMLNDRRR LALENYITAL QAVPPRPRHV FNMLKKYVRA EQKDRQHTLK 400
HFEHVRMVDP KKAAQIRSQV MTHLRVIYER MNQSLSLLYN VPAVAEEIQD 450
EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET KTTVELLPVN 500
GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN 550
IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG AIIGLMVGGV 600
VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP 650
TYKFFEQMQN 660
Length:660
Mass (Da):75,110
Last modified:April 5, 2011 - v1
Checksum:i7EC5DD46A8729202
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001439 Genomic DNA. No translation available.
AP001440 Genomic DNA. No translation available.
AP001441 Genomic DNA. No translation available.
AP001442 Genomic DNA. No translation available.
AP001443 Genomic DNA. No translation available.
RefSeqiNP_001129603.1. NM_001136131.2.
UniGeneiHs.434980.

Genome annotation databases

EnsembliENST00000448388; ENSP00000388538; ENSG00000142192.
GeneIDi351.
KEGGihsa:351.
UCSCiuc011aci.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001439 Genomic DNA. No translation available.
AP001440 Genomic DNA. No translation available.
AP001441 Genomic DNA. No translation available.
AP001442 Genomic DNA. No translation available.
AP001443 Genomic DNA. No translation available.
RefSeqi NP_001129603.1. NM_001136131.2.
UniGenei Hs.434980.

3D structure databases

ProteinModelPortali E9PEV0.
SMRi E9PEV0. Positions 1-157, 275-457, 573-618, 631-658.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9PEV0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000448388 ; ENSP00000388538 ; ENSG00000142192 .
GeneIDi 351.
KEGGi hsa:351.
UCSCi uc011aci.2. human.

Organism-specific databases

CTDi 351.
HGNCi HGNC:620. APP.
GenAtlasi Search...

Phylogenomic databases

KOi K04520.

Miscellaneous databases

ChiTaRSi app. human.
GenomeRNAii 351.
NextBioi 35501774.

Gene expression databases

ArrayExpressi E9PEV0.
Bgeei E9PEV0.

Family and domain databases

Gene3Di 3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
InterProi IPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
[Graphical view ]
PANTHERi PTHR23103:SF7. PTHR23103:SF7. 1 hit.
Pfami PF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
[Graphical view ]
PRINTSi PR00203. AMYLOIDA4.
PR00204. BETAAMYLOID.
SMARTi SM00006. A4_EXTRA. 1 hit.
[Graphical view ]
SUPFAMi SSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEi PS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 21."
    Chromosome 21 mapping and sequencing consortium
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PEV0_HUMAN
AccessioniPrimary (citable) accession number: E9PEV0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi