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E9PER6

- E9PER6_HUMAN

UniProt

E9PER6 - E9PER6_HUMAN

Protein
Submitted name:

3-phosphoinositide-dependent protein kinase 1

Gene

PDPK1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 3-phosphoinositide-dependent protein kinase activity Source: Ensembl
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. focal adhesion assembly Source: Ensembl
    2. hyperosmotic response Source: Ensembl
    3. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
    4. negative regulation of toll-like receptor signaling pathway Source: Ensembl
    5. regulation of endothelial cell migration Source: Ensembl
    6. regulation of mast cell degranulation Source: Ensembl
    7. type B pancreatic cell development Source: Ensembl

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiE9PER6.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    3-phosphoinositide-dependent protein kinase 1Imported
    Gene namesi
    Name:PDPK1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:8816. PDPK1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytoplasmic membrane-bounded vesicle Source: Ensembl
    3. cytosol Source: Ensembl
    4. plasma membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiE9PER6.

    Expressioni

    Gene expression databases

    ArrayExpressiE9PER6.
    BgeeiE9PER6.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PER6.
    SMRiE9PER6. Positions 48-529.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK06276.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    InterProiIPR011009. Kinase-like_dom.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PER6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRTQTESST PPGIPGGSRQ GPAMDGTAAE PRPGAGSLQH AQPPPQPRKK    50
    RPEDFKFGKI LGEGSFSTVV LARELATSRE YAIKILEKRH IIKENKVPYV 100
    TRERDVMSRL DHPFFVKLYF TFQDDEKLYF GLSYAKNGEL LKYIRKIGSF 150
    DETCTRFYTA EIVSALEYLH GKGIIHRDLK PENILLNEDM HIQITDFGTA 200
    KVLSPESKQA RANSFVGTAQ YVSPELLTEK SACKSSDLWA LGCIIYQLVA 250
    GLPPFRAGNE YLIFQKIIKL EYDFPEKFFP KARDLVEKLL VLDATKRLGC 300
    EEMEGYGPLK AHPFFESVTW ENLHQQTPPK LTAYLPAMSE DDEDCYGNYD 350
    NLLSQFGCMQ VSSSSSSHSL SASDTGLPQR SGSNIEQYIH DLDSNSFELD 400
    LQFSEDEKRL LLEKQAGGNP WHQFVENNLI LKMGPVDKRK GLFARRRQLL 450
    LTEGPHLYYV DPVNKVLKGE IPWSQELRPE AKNFKTFFVH TPNRTYYLMD 500
    PSGNAHKWCR KIQEVWRQRY QSHPDAAVQ 529
    Length:529
    Mass (Da):60,329
    Last modified:April 5, 2011 - v1
    Checksum:iD2E118E969E45DF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093525 Genomic DNA. No translation available.
    AC141586 Genomic DNA. No translation available.
    RefSeqiXP_005255413.1. XM_005255356.1.
    UniGeneiHs.459691.

    Genome annotation databases

    EnsembliENST00000389224; ENSP00000373876; ENSG00000140992.
    GeneIDi5170.
    KEGGihsa:5170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093525 Genomic DNA. No translation available.
    AC141586 Genomic DNA. No translation available.
    RefSeqi XP_005255413.1. XM_005255356.1.
    UniGenei Hs.459691.

    3D structure databases

    ProteinModelPortali E9PER6.
    SMRi E9PER6. Positions 48-529.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9PER6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000389224 ; ENSP00000373876 ; ENSG00000140992 .
    GeneIDi 5170.
    KEGGi hsa:5170.

    Organism-specific databases

    CTDi 5170.
    HGNCi HGNC:8816. PDPK1.
    GenAtlasi Search...

    Phylogenomic databases

    KOi K06276.

    Enzyme and pathway databases

    SignaLinki E9PER6.

    Miscellaneous databases

    ChiTaRSi PDPK1. human.
    GenomeRNAii 5170.
    NextBioi 35501766.

    Gene expression databases

    ArrayExpressi E9PER6.
    Bgeei E9PER6.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    InterProi IPR011009. Kinase-like_dom.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE9PER6_HUMAN
    AccessioniPrimary (citable) accession number: E9PER6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3