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Protein

Phospholipid-transporting ATPase

Gene

ATP11A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
Name:ATP11AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000068650.18.
HGNCiHGNC:13552. ATP11A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei69 – 87HelicalUniRule annotationAdd BLAST19
Transmembranei295 – 318HelicalUniRule annotationAdd BLAST24
Transmembranei349 – 368HelicalUniRule annotationAdd BLAST20
Transmembranei965 – 987HelicalUniRule annotationAdd BLAST23
Transmembranei999 – 1021HelicalUniRule annotationAdd BLAST23
Transmembranei1033 – 1057HelicalUniRule annotationAdd BLAST25
Transmembranei1063 – 1088HelicalUniRule annotationAdd BLAST26

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000068650.

PTM / Processingi

Proteomic databases

EPDiE9PEJ6.
MaxQBiE9PEJ6.
PaxDbiE9PEJ6.
PRIDEiE9PEJ6.

Expressioni

Gene expression databases

BgeeiENSG00000068650.
ExpressionAtlasiE9PEJ6. baseline and differential.
GenevisibleiE9PEJ6. HS.

Structurei

3D structure databases

ProteinModelPortaliE9PEJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 96PhoLip_ATPase_NInterPro annotationAdd BLAST55
Domaini851 – 1103PhoLip_ATPase_CInterPro annotationAdd BLAST253

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili628 – 652Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00870000136387.
OMAiGIDMIDS.
OrthoDBiEOG091G03B1.
PhylomeDBiE9PEJ6.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR030361. ATP11A.
IPR023299. ATPase_P-typ_cyto_dom_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom_sf.
IPR008250. ATPase_P-typ_transduc_dom_A_sf.
IPR036412. HAD-like_sf.
IPR023214. HAD_sf.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF33. PTHR24092:SF33. 1 hit.
PfamiView protein in Pfam
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 2 hits.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PEJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCSLVRTLV HRYCAGEENW VDSRTIYVGH REPPPGAEAY IPQRYPDNRI
60 70 80 90 100
VSSKYTFWNF IPKNLFEQFR RVANFYFLII FLVQLIIDTP TSPVTSGLPL
110 120 130 140 150
FFVITVTAIK QGYEDWLRHK ADNAMNQCPV HFIQHGKLVR KQSRKLRVGD
160 170 180 190 200
IVMVKEDETF PCDLIFLSSN RGDGTCHVTT ASLDGESSHK THYAVQDTKG
210 220 230 240 250
FHTEEDIGGL HATIECEQPQ PDLYKFVGRI NVYSDLNDPV VRPLGSENLL
260 270 280 290 300
LRGATLKNTE KIFGVAIYTG METKMALNYQ SKSQKRSAVE KSMNAFLIVY
310 320 330 340 350
LCILISKALI NTVLKYMWQS EPFRDEPWYN QKTESERQRN LFLKAFTDFL
360 370 380 390 400
AFMVLFNYII PVSMYVTVEM QKFLGSYFIT WDEDMFDEET GEGPLVNTSD
410 420 430 440 450
LNEELGQVEY IFTDKTGTLT ENNMEFKECC IEGHVYVPHV ICNGQVLPES
460 470 480 490 500
SGIDMIDSSP SVNGREREEL FFRALCLCHT VQVKDDDSVD GPRKSPDGGK
510 520 530 540 550
SCVYISSSPD EVALVEGVQR LGFTYLRLKD NYMEILNREN HIERFELLEI
560 570 580 590 600
LSFDSVRRRM SVIVKSATGE IYLFCKGADS SIFPRVIEGK VDQIRARVER
610 620 630 640 650
NAVEGLRTLC VAYKRLIQEE YEGICKLLQA AKVALQDREK KLAEAYEQIE
660 670 680 690 700
KDLTLLGATA VEDRLQEKAA DTIEALQKAG IKVWVLTGDK METAAATCYA
710 720 730 740 750
CKLFRRNTQL LELTTKRIEE QSLHDVLFEL SKTVLRHSGS LTRDNLSGLS
760 770 780 790 800
ADMQDYGLII DGAALSLIMK PREDGSSGNY RELFLEICRS CSAVLCCRMA
810 820 830 840 850
PLQKAQIVKL IKFSKEHPIT LAIGDGANDV SMILEAHVGI GVIGKEGRQA
860 870 880 890 900
ARNSDYAIPK FKHLKKMLLV HGHFYYIRIS ELVQYFFYKN VCFIFPQFLY
910 920 930 940 950
QFFCGFSQQT LYDTAYLTLY NISFTSLPIL LYSLMEQHVG IDVLKRDPTL
960 970 980 990 1000
YRDVAKNALL RWRVFIYWTL LGLFDALVFF FGAYFVFENT TVTSNGQIFG
1010 1020 1030 1040 1050
NWTFGTLVFT VMVFTVTLKL ALDTHYWTWI NHFVIWGSLL FYVVFSLLWG
1060 1070 1080 1090 1100
GVIWPFLNYQ RMYYVFIQML SSGPAWLAIV LLVTISLLPD VLKKVLCRQL
1110 1120 1130 1140 1150
WPTATERVQN GCAQPRDRDS EFTPLASLQS PGYQSTCPSA AWYSSHSQQV
1160 1170 1180 1190
TLAAWKEKVS TEPPPILGGS HHHCSSIPSH SCPRSRVGML V
Length:1,191
Mass (Da):135,847
Last modified:April 5, 2011 - v1
Checksum:i1A4535B7979B4892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139384 Genomic DNA. No translation available.
AL162711 Genomic DNA. No translation available.
AL356740 Genomic DNA. No translation available.
AL356752 Genomic DNA. No translation available.
RefSeqiNP_115565.3. NM_032189.3.
UniGeneiHs.29189.

Genome annotation databases

EnsembliENST00000375630; ENSP00000364781; ENSG00000068650.
GeneIDi23250.
UCSCiuc001vsj.4. human.

Similar proteinsi

Entry informationi

Entry nameiE9PEJ6_HUMAN
AccessioniPrimary (citable) accession number: E9PEJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 22, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported