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E9PE75

- E9PE75_HUMAN

UniProt

E9PE75 - E9PE75_HUMAN

Protein
Submitted name:

Peroxisome biogenesis factor 1

Gene

PEX1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase activity, coupled Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein targeting to peroxisome Source: InterPro

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Peroxisome biogenesis factor 1Imported
    Gene namesi
    Name:PEX1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:8850. PEX1.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: HPA
    2. peroxisomal membrane Source: InterPro

    Expressioni

    Gene expression databases

    ArrayExpressiE9PE75.
    BgeeiE9PE75.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PE75.
    SMRiE9PE75. Positions 13-92, 272-775.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAA ATPase family.UniRule annotation

    Phylogenomic databases

    OrthoDBiEOG7W9RT0.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR009010. Asp_de-COase-like_dom.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    IPR015343. Peroxisome_synth_fac_1_a/b.
    IPR025653. Pex1.
    [Graphical view]
    PANTHERiPTHR23077:SF12. PTHR23077:SF12. 1 hit.
    PfamiPF00004. AAA. 2 hits.
    PF09263. PEX-2N. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PE75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWGSDRLAGA GGGGAAVTVA FTNARDCFLH LPRRLVAQLH LLQNQAIEVV    50
    WSHQPAFLSW VEGRHFSDQG ENVAEINRQV GQKLGLSNGG QIPDDLRKRL 100
    NIEMHAVVRI TPVEVTPKIP RSLKLQPREN LPKDISEEDI KTVFYSWLQQ 150
    STTTMLPLVI SEEEFIKLET KDGLKEFSLS IVHSWEKEKD KNIFLLSPNL 200
    LQKTTIQVLL DPMVKEENSE EIDFILPFLK LSSLGGVNSL GVSSLEHITH 250
    SLLGRPLSRQ LMSLVAGLRN GALLLTGGKG SGKSTLAKAI CKEAFDKLDA 300
    HVERVDCKAL RGKRLENIQK TLEVAFSEAV WMQPSVVLLD DLDLIAGLPA 350
    VPEHEHSPDA VQSQRLAHAL NDMIKEFISM GSLVALIATS QSQQSLHPLL 400
    VSAQGVHIFQ CVQHIQPPNQ EQRCEILCNV IKNKLDCDIN KFTDLDLQHV 450
    AKETGGFVAR DFTVLVDRAI HSRLSRQSIS TREKLVLTTL DFQKALRGFL 500
    PASLRSVNLH KPRDLGWDKI GGLHEVRQIL MDTIQLPAKY PELFANLPIR 550
    QRTGILLYGP PGTGKTLLAG VIARESRMNF ISVKGPELLS KYIGASEQAV 600
    RDIFIRAQAA KPCILFFDEF ESIAPRRGHD NTGVTDRVVN QLLTQLDGVE 650
    GLQGVYVLAA TSRPDLIDPA LLRPGRLDKC VYCPPPDQVS RLEILNVLSD 700
    SLPLADDVDL QHVASVTDSF TGADLKALLY NAQLEALHGM LLSSGLQDGS 750
    SSSDSDLSLS SMVFLNHSSG SDDSAGDGEC GLDQSLVSLE MSEILPDESK 800
    FNMYRLYFGS SYESELGNGT SSDLSSQCLS APSSMTQDLP GVPGKDQLFS 850
    QPPVLRTASQ EGCQELTQEQ RDQLRADISI IKGRYRSQSG EDESMNQPGP 900
    IKTRLAISQS HLMTALGHTR PSISEDDWKN FAELYESFQN PKRRKNQSGT 950
    MFRPGQKVTL A 961
    Length:961
    Mass (Da):105,999
    Last modified:April 5, 2011 - v1
    Checksum:iE768626F405F9534
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007566 Genomic DNA. No translation available.
    KF458517 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000438045; ENSP00000410438; ENSG00000127980.
    UCSCiuc011khs.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007566 Genomic DNA. No translation available.
    KF458517 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E9PE75.
    SMRi E9PE75. Positions 13-92, 272-775.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000438045 ; ENSP00000410438 ; ENSG00000127980 .
    UCSCi uc011khs.2. human.

    Organism-specific databases

    HGNCi HGNC:8850. PEX1.
    GenAtlasi Search...

    Phylogenomic databases

    OrthoDBi EOG7W9RT0.

    Miscellaneous databases

    NextBioi 35501712.

    Gene expression databases

    ArrayExpressi E9PE75.
    Bgeei E9PE75.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR009010. Asp_de-COase-like_dom.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    IPR015343. Peroxisome_synth_fac_1_a/b.
    IPR025653. Pex1.
    [Graphical view ]
    PANTHERi PTHR23077:SF12. PTHR23077:SF12. 1 hit.
    Pfami PF00004. AAA. 2 hits.
    PF09263. PEX-2N. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE9PE75_HUMAN
    AccessioniPrimary (citable) accession number: E9PE75
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3