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E9PE75

- E9PE75_HUMAN

UniProt

E9PE75 - E9PE75_HUMAN

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Protein
Submitted name:

Peroxisome biogenesis factor 1

Gene
PEX1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATPase activity, coupled Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein targeting to peroxisome Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome biogenesis factor 1Imported
Gene namesi
Name:PEX1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:8850. PEX1.

Subcellular locationi

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: HPA
  2. peroxisomal membrane Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiE9PE75.
BgeeiE9PE75.

Structurei

3D structure databases

ProteinModelPortaliE9PE75.
SMRiE9PE75. Positions 13-92, 272-775.

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Phylogenomic databases

OrthoDBiEOG7W9RT0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015343. Peroxisome_synth_fac_1_a/b.
IPR025653. Pex1.
[Graphical view]
PANTHERiPTHR23077:SF12. PTHR23077:SF12. 1 hit.
PfamiPF00004. AAA. 2 hits.
PF09263. PEX-2N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PE75-1 [UniParc]FASTAAdd to Basket

« Hide

MWGSDRLAGA GGGGAAVTVA FTNARDCFLH LPRRLVAQLH LLQNQAIEVV    50
WSHQPAFLSW VEGRHFSDQG ENVAEINRQV GQKLGLSNGG QIPDDLRKRL 100
NIEMHAVVRI TPVEVTPKIP RSLKLQPREN LPKDISEEDI KTVFYSWLQQ 150
STTTMLPLVI SEEEFIKLET KDGLKEFSLS IVHSWEKEKD KNIFLLSPNL 200
LQKTTIQVLL DPMVKEENSE EIDFILPFLK LSSLGGVNSL GVSSLEHITH 250
SLLGRPLSRQ LMSLVAGLRN GALLLTGGKG SGKSTLAKAI CKEAFDKLDA 300
HVERVDCKAL RGKRLENIQK TLEVAFSEAV WMQPSVVLLD DLDLIAGLPA 350
VPEHEHSPDA VQSQRLAHAL NDMIKEFISM GSLVALIATS QSQQSLHPLL 400
VSAQGVHIFQ CVQHIQPPNQ EQRCEILCNV IKNKLDCDIN KFTDLDLQHV 450
AKETGGFVAR DFTVLVDRAI HSRLSRQSIS TREKLVLTTL DFQKALRGFL 500
PASLRSVNLH KPRDLGWDKI GGLHEVRQIL MDTIQLPAKY PELFANLPIR 550
QRTGILLYGP PGTGKTLLAG VIARESRMNF ISVKGPELLS KYIGASEQAV 600
RDIFIRAQAA KPCILFFDEF ESIAPRRGHD NTGVTDRVVN QLLTQLDGVE 650
GLQGVYVLAA TSRPDLIDPA LLRPGRLDKC VYCPPPDQVS RLEILNVLSD 700
SLPLADDVDL QHVASVTDSF TGADLKALLY NAQLEALHGM LLSSGLQDGS 750
SSSDSDLSLS SMVFLNHSSG SDDSAGDGEC GLDQSLVSLE MSEILPDESK 800
FNMYRLYFGS SYESELGNGT SSDLSSQCLS APSSMTQDLP GVPGKDQLFS 850
QPPVLRTASQ EGCQELTQEQ RDQLRADISI IKGRYRSQSG EDESMNQPGP 900
IKTRLAISQS HLMTALGHTR PSISEDDWKN FAELYESFQN PKRRKNQSGT 950
MFRPGQKVTL A 961
Length:961
Mass (Da):105,999
Last modified:April 5, 2011 - v1
Checksum:iE768626F405F9534
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007566 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000438045; ENSP00000410438; ENSG00000127980.
UCSCiuc011khs.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007566 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9PE75.
SMRi E9PE75. Positions 13-92, 272-775.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000438045 ; ENSP00000410438 ; ENSG00000127980 .
UCSCi uc011khs.2. human.

Organism-specific databases

HGNCi HGNC:8850. PEX1.
GenAtlasi Search...

Phylogenomic databases

OrthoDBi EOG7W9RT0.

Miscellaneous databases

GenomeRNAii 5189.
NextBioi 35501712.

Gene expression databases

ArrayExpressi E9PE75.
Bgeei E9PE75.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015343. Peroxisome_synth_fac_1_a/b.
IPR025653. Pex1.
[Graphical view ]
PANTHERi PTHR23077:SF12. PTHR23077:SF12. 1 hit.
Pfami PF00004. AAA. 2 hits.
PF09263. PEX-2N. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PE75_HUMAN
AccessioniPrimary (citable) accession number: E9PE75
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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