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Protein
Submitted name:

WD repeat-containing protein 6

Gene

WDR6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiE9PDU5.

Names & Taxonomyi

Protein namesi
Submitted name:
WD repeat-containing protein 6Imported
Gene namesi
Name:WDR6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:12758. WDR6.

PTM / Processingi

Proteomic databases

EPDiE9PDU5.
PaxDbiE9PDU5.
PRIDEiE9PDU5.

Expressioni

Gene expression databases

BgeeiE9PDU5.
ExpressionAtlasiE9PDU5. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiE9PDU5. 1 interaction.
MINTiMINT-8395075.
STRINGi9606.ENSP00000378857.

Structurei

3D structure databases

ProteinModelPortaliE9PDU5.
SMRiE9PDU5. Positions 124-276, 924-960.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini154 – 284131WD_REPEATS_REGIONInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0974. Eukaryota.
ENOG410ZJ6J. LUCA.
GeneTreeiENSGT00420000029923.
OrthoDBiEOG76T9QR.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR011044. Quino_amine_DH_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 2 hits.
SSF50978. SSF50978. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PDU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKRVQNLLG HYLIHGFRVR PEPNGDLDLE AMVAVFGSKG LRVVKISWGQ
60 70 80 90 100
GHFWELWRSG LWNMSDWIWD ARWLEGNIAL ALGHNSVVLY DPVVGCILQE
110 120 130 140 150
VPCTDRCTLS SACLIGDAWK ELTIVAGAVS NQLLVWYPAT ALADNKPVAP
160 170 180 190 200
DRRISGHVGI IFSMSYLESK GLLATASEDR SVRIWKVGDL RVPGGRVQNI
210 220 230 240 250
GHCFGHSARV WQVKLLENYL ISAGEDCVCL VWSHEGEILQ AFRGHQGRGI
260 270 280 290 300
RAIAAHERQA WVITGGDDSG IRLWHLVGRG YRGLGVSALC FKSRSRPGTL
310 320 330 340 350
KAVTLAGSWR LLAVTDTGAL YLYDVEVKCW EQLLEDKHFQ SYCLLEAAPG
360 370 380 390 400
PEGFGLCAMA NGEGRVKVVP INTPTAAVDQ TLFPGKVHSL SWALRGYEEL
410 420 430 440 450
LLLASGPGGV VACLEISAAP SGKAIFVKER CRYLLPPSKQ RWHTCSAFLP
460 470 480 490 500
PGDFLVCGDR RGSVLLFPSR PGLLKDPGVG GKARAGAGAP VVGSGSSGGG
510 520 530 540 550
NAFTGLGPVS TLPSLHGKQG VTSVTCHGGY VYTTGRDGAY YQLFVRDGQL
560 570 580 590 600
QPVLRQKSCR GMNWLAGLRI VPDGSMVILG FHANEFVVWN PRSHEKLHIV
610 620 630 640 650
NCGGGHRSWA FSDTEAAMAF AYLKDGDVML YRALGGCTRP HVILREGLHG
660 670 680 690 700
REITCVKRVG TITLGPEYGV PSFMQPDDLE PGSEGPDLTD IVITCSEDTT
710 720 730 740 750
VCVLALPTTT GSAHALTAVC NHISSVRAVA VWGIGTPGGP QDPQPGLTAH
760 770 780 790 800
VVSAGGRAEM HCFSIMVTPD PSTPSRLACH VMHLSSHRLD EYWDRQRNRH
810 820 830 840 850
RMVKVDPETR YMSLAVCELD QPGLGPLVAA ACSDGAVRLF LLQDSGRILQ
860 870 880 890 900
LLAETFHHKR CVLKVHSFTH EAPNQRRRLL LCSAATDGSL AFWDLTTMLD
910 920 930 940 950
HDSTVLEPPV DPGLPYRLGT PSLTLQAHSC GINSLHTLPT REGHHLVASG
960 970 980 990 1000
SEDGSLHVFV LAVEMLQLEE AVGEAGLVPQ LRVLEEYSVP CAHAAHVTGL
1010 1020 1030 1040 1050
KILSPSIMVS ASIDQRLTFW RLGHGEPTFM NSTVFHVPDV ADMDCWPVSP
1060 1070
EFGHRCALGG QGLEVYNWYD
Length:1,070
Mass (Da):116,169
Last modified:April 5, 2011 - v1
Checksum:iFD68E7D9589F3D01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137630 Genomic DNA. No translation available.
RefSeqiNP_001307476.1. NM_001320547.1.
UniGeneiHs.654815.

Genome annotation databases

EnsembliENST00000448293; ENSP00000413432; ENSG00000178252.
GeneIDi11180.
UCSCiuc011bbz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137630 Genomic DNA. No translation available.
RefSeqiNP_001307476.1. NM_001320547.1.
UniGeneiHs.654815.

3D structure databases

ProteinModelPortaliE9PDU5.
SMRiE9PDU5. Positions 124-276, 924-960.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9PDU5. 1 interaction.
MINTiMINT-8395075.
STRINGi9606.ENSP00000378857.

Proteomic databases

EPDiE9PDU5.
PaxDbiE9PDU5.
PRIDEiE9PDU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000448293; ENSP00000413432; ENSG00000178252.
GeneIDi11180.
UCSCiuc011bbz.2. human.

Organism-specific databases

CTDi11180.
HGNCiHGNC:12758. WDR6.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0974. Eukaryota.
ENOG410ZJ6J. LUCA.
GeneTreeiENSGT00420000029923.
OrthoDBiEOG76T9QR.

Enzyme and pathway databases

SignaLinkiE9PDU5.

Miscellaneous databases

ChiTaRSiWDR6. human.
GenomeRNAii11180.

Gene expression databases

BgeeiE9PDU5.
ExpressionAtlasiE9PDU5. baseline and differential.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR011044. Quino_amine_DH_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 2 hits.
SSF50978. SSF50978. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PDU5_HUMAN
AccessioniPrimary (citable) accession number: E9PDU5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.