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E9PDF2

- E9PDF2_HUMAN

UniProt

E9PDF2 - E9PDF2_HUMAN

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Protein
Submitted name:

2-oxoglutarate dehydrogenase, mitochondrial

Gene

OGDH

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase, mitochondrialImported
Gene namesi
Name:OGDHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:8124. OGDH.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9PDF2.

Expressioni

Gene expression databases

BgeeiE9PDF2.
ExpressionAtlasiE9PDF2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PDF2.
SMRiE9PDF2. Positions 130-1025.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063092.
KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PDF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFQQIRCY SAPVAAEPFL
60 70 80 90 100
SGTSSNYVEE MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS
110 120 130 140 150
RGSLAAVAHA QSLVEAQPNV DKLVEDHLAV QSLIRAYQVR GHHIAKLDPL
160 170 180 190 200
GISCVNFDDA PVTVSSNVDL AVFKERLRML TVGGFYGLDE SDLDKVFHLP
210 220 230 240 250
TTTFIGGQES ALPLREIIRR LEMAYCQHIG VEFMFINDLE QCQWIRQKFE
260 270 280 290 300
TPGIMQFTNE EKRTLLARLV RSTRFEEFLQ RKWSSEKRFG LEGCEVLIPA
310 320 330 340 350
LKTIIDKSSE NGVDYVIMGM PHRGRLNVLA NVIRKELEQI FCQFDSKLEA
360 370 380 390 400
ADEGSGDVKY HLGMYHRRIN RVTDRNITLS LVANPSHLEA ADPVVMGKTK
410 420 430 440 450
AEQFYCGDTE GKKVMSILLH GDAAFAGQGI VYETFHLSDL PSYTTHGTVH
460 470 480 490 500
VVVNNQIGFT TDPRMARSSP YPTDVARVVN APIFHVNSDD PEAVMYVCKV
510 520 530 540 550
AAEWRSTFHK DVVVDLVCYR RNGHNEMDEP MFTQPLMYKQ IRKQKPVLQK
560 570 580 590 600
YAELLVSQGV VNQPEYEEEI SKYDKICEEA FARSKDEKIL HIKHWLDSPW
610 620 630 640 650
PGFFTLDGQP RSMSCPSTGL TEDILTHIGN VASSVPVENF TIHGGLSRIL
660 670 680 690 700
KTRGEMVKNR TVDWALAEYM AFGSLLKEGI HIRLSGQDVE RGTFSHRHHV
710 720 730 740 750
LHDQNVDKRT CIPMNHLWPN QAPYTVCNSS LSEYGVLGFE LGFAMASPNA
760 770 780 790 800
LVLWEAQFGD FHNTAQCIID QFICPGQAKW VRQNGIVLLL PHGMEGMGPE
810 820 830 840 850
HSSARPERFL QMCNDDPDVL PDLKEANFDI NQLYDCNWVV VNCSTPGNFF
860 870 880 890 900
HVLRRQILLP FRKPLIIFTP KSLLRHPEAR SSFDEMLPGT HFQRVIPEDG
910 920 930 940 950
PAAQNPENVK RLLFCTGKVY YDLTRERKAR DMVGQVAITR IEQLSPFPFD
960 970 980 990 1000
LLLKEVQKYP NAELAWCQEE HKNQGYYDYV KPRLRTTISR AKPVWYAGRD
1010 1020 1030
PAAAPATGNK KTHLTELQRL LDTAFDLDVF KNFS
Length:1,034
Mass (Da):117,244
Last modified:April 5, 2011 - v1
Checksum:i2AC4BD2DE7077487
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004859 Genomic DNA. No translation available.
AC011894 Genomic DNA. No translation available.
RefSeqiXP_005249818.1. XM_005249761.2.
UniGeneiHs.488181.

Genome annotation databases

EnsembliENST00000447398; ENSP00000388183; ENSG00000105953.
GeneIDi4967.
KEGGihsa:4967.
UCSCiuc003tlp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004859 Genomic DNA. No translation available.
AC011894 Genomic DNA. No translation available.
RefSeqi XP_005249818.1. XM_005249761.2.
UniGenei Hs.488181.

3D structure databases

ProteinModelPortali E9PDF2.
SMRi E9PDF2. Positions 130-1025.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9PDF2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000447398 ; ENSP00000388183 ; ENSG00000105953 .
GeneIDi 4967.
KEGGi hsa:4967.
UCSCi uc003tlp.3. human.

Organism-specific databases

CTDi 4967.
HGNCi HGNC:8124. OGDH.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000063092.
KOi K00164.

Miscellaneous databases

ChiTaRSi OGDH. human.
GenomeRNAii 4967.
NextBioi 35501634.

Gene expression databases

Bgeei E9PDF2.
ExpressionAtlasi E9PDF2. baseline and differential.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PDF2_HUMAN
AccessioniPrimary (citable) accession number: E9PDF2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3