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E9PDF2

- E9PDF2_HUMAN

UniProt

E9PDF2 - E9PDF2_HUMAN

Protein
Submitted name:

2-oxoglutarate dehydrogenase, mitochondrial

Gene

OGDH

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    2-oxoglutarate dehydrogenase, mitochondrialImported
    Gene namesi
    Name:OGDHImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:8124. OGDH.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: HPA

    PTM / Processingi

    Proteomic databases

    PRIDEiE9PDF2.

    Expressioni

    Gene expression databases

    ArrayExpressiE9PDF2.
    BgeeiE9PDF2.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PDF2.
    SMRiE9PDF2. Positions 130-1025.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK00164.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E9PDF2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFQQIRCY SAPVAAEPFL     50
    SGTSSNYVEE MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS 100
    RGSLAAVAHA QSLVEAQPNV DKLVEDHLAV QSLIRAYQVR GHHIAKLDPL 150
    GISCVNFDDA PVTVSSNVDL AVFKERLRML TVGGFYGLDE SDLDKVFHLP 200
    TTTFIGGQES ALPLREIIRR LEMAYCQHIG VEFMFINDLE QCQWIRQKFE 250
    TPGIMQFTNE EKRTLLARLV RSTRFEEFLQ RKWSSEKRFG LEGCEVLIPA 300
    LKTIIDKSSE NGVDYVIMGM PHRGRLNVLA NVIRKELEQI FCQFDSKLEA 350
    ADEGSGDVKY HLGMYHRRIN RVTDRNITLS LVANPSHLEA ADPVVMGKTK 400
    AEQFYCGDTE GKKVMSILLH GDAAFAGQGI VYETFHLSDL PSYTTHGTVH 450
    VVVNNQIGFT TDPRMARSSP YPTDVARVVN APIFHVNSDD PEAVMYVCKV 500
    AAEWRSTFHK DVVVDLVCYR RNGHNEMDEP MFTQPLMYKQ IRKQKPVLQK 550
    YAELLVSQGV VNQPEYEEEI SKYDKICEEA FARSKDEKIL HIKHWLDSPW 600
    PGFFTLDGQP RSMSCPSTGL TEDILTHIGN VASSVPVENF TIHGGLSRIL 650
    KTRGEMVKNR TVDWALAEYM AFGSLLKEGI HIRLSGQDVE RGTFSHRHHV 700
    LHDQNVDKRT CIPMNHLWPN QAPYTVCNSS LSEYGVLGFE LGFAMASPNA 750
    LVLWEAQFGD FHNTAQCIID QFICPGQAKW VRQNGIVLLL PHGMEGMGPE 800
    HSSARPERFL QMCNDDPDVL PDLKEANFDI NQLYDCNWVV VNCSTPGNFF 850
    HVLRRQILLP FRKPLIIFTP KSLLRHPEAR SSFDEMLPGT HFQRVIPEDG 900
    PAAQNPENVK RLLFCTGKVY YDLTRERKAR DMVGQVAITR IEQLSPFPFD 950
    LLLKEVQKYP NAELAWCQEE HKNQGYYDYV KPRLRTTISR AKPVWYAGRD 1000
    PAAAPATGNK KTHLTELQRL LDTAFDLDVF KNFS 1034
    Length:1,034
    Mass (Da):117,244
    Last modified:April 5, 2011 - v1
    Checksum:i2AC4BD2DE7077487
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004859 Genomic DNA. No translation available.
    AC011894 Genomic DNA. No translation available.
    RefSeqiXP_005249818.1. XM_005249761.2.
    UniGeneiHs.488181.

    Genome annotation databases

    EnsembliENST00000447398; ENSP00000388183; ENSG00000105953.
    GeneIDi4967.
    KEGGihsa:4967.
    UCSCiuc003tlp.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004859 Genomic DNA. No translation available.
    AC011894 Genomic DNA. No translation available.
    RefSeqi XP_005249818.1. XM_005249761.2.
    UniGenei Hs.488181.

    3D structure databases

    ProteinModelPortali E9PDF2.
    SMRi E9PDF2. Positions 130-1025.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9PDF2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000447398 ; ENSP00000388183 ; ENSG00000105953 .
    GeneIDi 4967.
    KEGGi hsa:4967.
    UCSCi uc003tlp.3. human.

    Organism-specific databases

    CTDi 4967.
    HGNCi HGNC:8124. OGDH.
    GenAtlasi Search...

    Phylogenomic databases

    KOi K00164.

    Miscellaneous databases

    ChiTaRSi OGDH. human.
    GenomeRNAii 4967.
    NextBioi 35501634.

    Gene expression databases

    ArrayExpressi E9PDF2.
    Bgeei E9PDF2.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE9PDF2_HUMAN
    AccessioniPrimary (citable) accession number: E9PDF2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3