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Protein
Submitted name:

2-oxoglutarate dehydrogenase, mitochondrial

Gene

OGDH

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase, mitochondrialImported
Gene namesi
Name:OGDHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105953.14
HGNCiHGNC:8124 OGDH

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105953

PTM / Processingi

Proteomic databases

MaxQBiE9PDF2
PeptideAtlasiE9PDF2
PRIDEiE9PDF2

Expressioni

Gene expression databases

BgeeiENSG00000105953
ExpressionAtlasiE9PDF2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PDF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini662 – 876Transket_pyrInterPro annotationAdd BLAST215

Phylogenomic databases

eggNOGiKOG0450 Eukaryota
COG0567 LUCA
GeneTreeiENSGT00530000063092

Family and domain databases

InterProiView protein in InterPro
IPR032106 2-oxogl_dehyd_N
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF16078 2-oxogl_dehyd_N, 1 hit
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit

Sequencei

Sequence statusi: Complete.

E9PDF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFQQIRCY SAPVAAEPFL
60 70 80 90 100
SGTSSNYVEE MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS
110 120 130 140 150
RGSLAAVAHA QSLVEAQPNV DKLVEDHLAV QSLIRAYQVR GHHIAKLDPL
160 170 180 190 200
GISCVNFDDA PVTVSSNVDL AVFKERLRML TVGGFYGLDE SDLDKVFHLP
210 220 230 240 250
TTTFIGGQES ALPLREIIRR LEMAYCQHIG VEFMFINDLE QCQWIRQKFE
260 270 280 290 300
TPGIMQFTNE EKRTLLARLV RSTRFEEFLQ RKWSSEKRFG LEGCEVLIPA
310 320 330 340 350
LKTIIDKSSE NGVDYVIMGM PHRGRLNVLA NVIRKELEQI FCQFDSKLEA
360 370 380 390 400
ADEGSGDVKY HLGMYHRRIN RVTDRNITLS LVANPSHLEA ADPVVMGKTK
410 420 430 440 450
AEQFYCGDTE GKKVMSILLH GDAAFAGQGI VYETFHLSDL PSYTTHGTVH
460 470 480 490 500
VVVNNQIGFT TDPRMARSSP YPTDVARVVN APIFHVNSDD PEAVMYVCKV
510 520 530 540 550
AAEWRSTFHK DVVVDLVCYR RNGHNEMDEP MFTQPLMYKQ IRKQKPVLQK
560 570 580 590 600
YAELLVSQGV VNQPEYEEEI SKYDKICEEA FARSKDEKIL HIKHWLDSPW
610 620 630 640 650
PGFFTLDGQP RSMSCPSTGL TEDILTHIGN VASSVPVENF TIHGGLSRIL
660 670 680 690 700
KTRGEMVKNR TVDWALAEYM AFGSLLKEGI HIRLSGQDVE RGTFSHRHHV
710 720 730 740 750
LHDQNVDKRT CIPMNHLWPN QAPYTVCNSS LSEYGVLGFE LGFAMASPNA
760 770 780 790 800
LVLWEAQFGD FHNTAQCIID QFICPGQAKW VRQNGIVLLL PHGMEGMGPE
810 820 830 840 850
HSSARPERFL QMCNDDPDVL PDLKEANFDI NQLYDCNWVV VNCSTPGNFF
860 870 880 890 900
HVLRRQILLP FRKPLIIFTP KSLLRHPEAR SSFDEMLPGT HFQRVIPEDG
910 920 930 940 950
PAAQNPENVK RLLFCTGKVY YDLTRERKAR DMVGQVAITR IEQLSPFPFD
960 970 980 990 1000
LLLKEVQKYP NAELAWCQEE HKNQGYYDYV KPRLRTTISR AKPVWYAGRD
1010 1020 1030
PAAAPATGNK KTHLTELQRL LDTAFDLDVF KNFS
Length:1,034
Mass (Da):117,244
Last modified:April 5, 2011 - v1
Checksum:i2AC4BD2DE7077487
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004859 Genomic DNA No translation available.
AC011894 Genomic DNA No translation available.
RefSeqiXP_005249818.1, XM_005249761.3
UniGeneiHs.488181

Genome annotation databases

EnsembliENST00000447398; ENSP00000388183; ENSG00000105953
GeneIDi4967
UCSCiuc064diu.1 human

Similar proteinsi

Entry informationi

Entry nameiE9PDF2_HUMAN
AccessioniPrimary (citable) accession number: E9PDF2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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