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E9PDF2

- E9PDF2_HUMAN

UniProt

E9PDF2 - E9PDF2_HUMAN

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Protein
Submitted name: 2-oxoglutarate dehydrogenase, mitochondrial
Gene
OGDH
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase, mitochondrialImported
Gene namesi
Name:OGDHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:8124. OGDH.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9PDF2.

Expressioni

Gene expression databases

ArrayExpressiE9PDF2.
BgeeiE9PDF2.

Structurei

3D structure databases

ProteinModelPortaliE9PDF2.
SMRiE9PDF2. Positions 130-1025.

Family & Domainsi

Phylogenomic databases

KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PDF2-1 [UniParc]FASTAAdd to Basket

« Hide

MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFQQIRCY SAPVAAEPFL     50
SGTSSNYVEE MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS 100
RGSLAAVAHA QSLVEAQPNV DKLVEDHLAV QSLIRAYQVR GHHIAKLDPL 150
GISCVNFDDA PVTVSSNVDL AVFKERLRML TVGGFYGLDE SDLDKVFHLP 200
TTTFIGGQES ALPLREIIRR LEMAYCQHIG VEFMFINDLE QCQWIRQKFE 250
TPGIMQFTNE EKRTLLARLV RSTRFEEFLQ RKWSSEKRFG LEGCEVLIPA 300
LKTIIDKSSE NGVDYVIMGM PHRGRLNVLA NVIRKELEQI FCQFDSKLEA 350
ADEGSGDVKY HLGMYHRRIN RVTDRNITLS LVANPSHLEA ADPVVMGKTK 400
AEQFYCGDTE GKKVMSILLH GDAAFAGQGI VYETFHLSDL PSYTTHGTVH 450
VVVNNQIGFT TDPRMARSSP YPTDVARVVN APIFHVNSDD PEAVMYVCKV 500
AAEWRSTFHK DVVVDLVCYR RNGHNEMDEP MFTQPLMYKQ IRKQKPVLQK 550
YAELLVSQGV VNQPEYEEEI SKYDKICEEA FARSKDEKIL HIKHWLDSPW 600
PGFFTLDGQP RSMSCPSTGL TEDILTHIGN VASSVPVENF TIHGGLSRIL 650
KTRGEMVKNR TVDWALAEYM AFGSLLKEGI HIRLSGQDVE RGTFSHRHHV 700
LHDQNVDKRT CIPMNHLWPN QAPYTVCNSS LSEYGVLGFE LGFAMASPNA 750
LVLWEAQFGD FHNTAQCIID QFICPGQAKW VRQNGIVLLL PHGMEGMGPE 800
HSSARPERFL QMCNDDPDVL PDLKEANFDI NQLYDCNWVV VNCSTPGNFF 850
HVLRRQILLP FRKPLIIFTP KSLLRHPEAR SSFDEMLPGT HFQRVIPEDG 900
PAAQNPENVK RLLFCTGKVY YDLTRERKAR DMVGQVAITR IEQLSPFPFD 950
LLLKEVQKYP NAELAWCQEE HKNQGYYDYV KPRLRTTISR AKPVWYAGRD 1000
PAAAPATGNK KTHLTELQRL LDTAFDLDVF KNFS 1034
Length:1,034
Mass (Da):117,244
Last modified:April 5, 2011 - v1
Checksum:i2AC4BD2DE7077487
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004859 Genomic DNA. No translation available.
AC011894 Genomic DNA. No translation available.
RefSeqiXP_005249818.1. XM_005249761.2.
UniGeneiHs.488181.

Genome annotation databases

EnsembliENST00000447398; ENSP00000388183; ENSG00000105953.
GeneIDi4967.
KEGGihsa:4967.
UCSCiuc003tlp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004859 Genomic DNA. No translation available.
AC011894 Genomic DNA. No translation available.
RefSeqi XP_005249818.1. XM_005249761.2.
UniGenei Hs.488181.

3D structure databases

ProteinModelPortali E9PDF2.
SMRi E9PDF2. Positions 130-1025.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9PDF2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000447398 ; ENSP00000388183 ; ENSG00000105953 .
GeneIDi 4967.
KEGGi hsa:4967.
UCSCi uc003tlp.3. human.

Organism-specific databases

CTDi 4967.
HGNCi HGNC:8124. OGDH.
GenAtlasi Search...

Phylogenomic databases

KOi K00164.

Miscellaneous databases

ChiTaRSi OGDH. human.
GenomeRNAii 4967.
NextBioi 35501634.

Gene expression databases

ArrayExpressi E9PDF2.
Bgeei E9PDF2.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PDF2_HUMAN
AccessioniPrimary (citable) accession number: E9PDF2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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