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Protein
Submitted name:

Heat shock 70 kDa protein 4L

Gene

HSPA4L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Heat shock 70 kDa protein 4LImported
Gene namesi
Name:HSPA4LImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:17041. HSPA4L.

PTM / Processingi

Proteomic databases

EPDiE9PDE8.
PaxDbiE9PDE8.

Expressioni

Gene expression databases

BgeeiE9PDE8.
ExpressionAtlasiE9PDE8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296464.

Structurei

3D structure databases

ProteinModelPortaliE9PDE8.
SMRiE9PDE8. Positions 11-542, 545-674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili580 – 60425Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000016919.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 2 hits.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PDE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPILLFMER ACISLGSRTR AIGNAAKSQI VTNVRNTIHG FKKLHGRSFD
60 70 80 90 100
DPIVQTERIR LPYELQKMPN GSAGVKVRYL EEERPFAIEQ VTGMLLAKLK
110 120 130 140 150
ETSENALKKP VADCVISIPS FFTDAERRSV MAAAQVAGLN CLRLMNETTA
160 170 180 190 200
VALAYGIYKQ DLPPLDEKPR NVVFIDMGHS AYQVLVCAFN KGKLKVLATT
210 220 230 240 250
FDPYLGGRNF DEALVDYFCD EFKTKYKINV KENSRALLRL YQECEKLKKL
260 270 280 290 300
MSANASDLPL NIECFMNDLD VSSKMNRAQF EQLCASLLAR VEPPLKAVME
310 320 330 340 350
QANLQREDIS SIEIVGGATR IPAVKEQITK FFLKDISTTL NADEAVARGC
360 370 380 390 400
ALQCAILSPA FKVREFSITD LVPYSITLRW KTSFEDGSGE CEVFCKNHPA
410 420 430 440 450
PFSKVITFHK KEPFELEAFY TNLHEVPYPD ARIGSFTIQN VFPQSDGDSS
460 470 480 490 500
KVKVKVRVNI HGIFSVASAS VIEKQNLEGD HSDAPMETET SFKNENKDNM
510 520 530 540 550
DKMQVDQEEG HQKCHAEHTP EEEIDHTGAK TKSAVSDKQD RLNQTLKKGK
560 570 580 590 600
VKSIDLPIQS SLCRQLGQDL LNSYIENEGK MIMQDKLEKE RNDAKNAVEE
610 620 630 640 650
YVYDFRDRLG TVYEKFITPE DLSKLSAVLE DTENWLYEDG EDQPKQVYVD
660 670 680 690 700
KLQELKKYGQ PIQMKYMEHE ERPKALNDLG KKIQLVMKVI EAYRNKDERY
710 720 730 740 750
DHLDPTEMEK VEKCISDAMS WLNSKMNAQN KLSLTQDPVV KVSEIVAKSK
760 770 780 790 800
ELDNFCNPII YKPKPKAEVP EDKPKANSEH NGPMDGQSGT ETKSDSTKDS
810
SQHTKSSGEM EVD
Length:813
Mass (Da):91,954
Last modified:April 5, 2011 - v1
Checksum:i074485F95E01133F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093591 Genomic DNA. No translation available.
RefSeqiNP_001304311.1. NM_001317382.1.
UniGeneiHs.135554.

Genome annotation databases

EnsembliENST00000505726; ENSP00000425645; ENSG00000164070.
GeneIDi22824.
UCSCiuc062zlv.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093591 Genomic DNA. No translation available.
RefSeqiNP_001304311.1. NM_001317382.1.
UniGeneiHs.135554.

3D structure databases

ProteinModelPortaliE9PDE8.
SMRiE9PDE8. Positions 11-542, 545-674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000296464.

Proteomic databases

EPDiE9PDE8.
PaxDbiE9PDE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000505726; ENSP00000425645; ENSG00000164070.
GeneIDi22824.
UCSCiuc062zlv.1. human.

Organism-specific databases

CTDi22824.
HGNCiHGNC:17041. HSPA4L.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000016919.

Miscellaneous databases

ChiTaRSiHSPA4L. human.
GenomeRNAii22824.

Gene expression databases

BgeeiE9PDE8.
ExpressionAtlasiE9PDE8. baseline and differential.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 2 hits.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  6. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE9PDE8_HUMAN
AccessioniPrimary (citable) accession number: E9PDE8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.