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Protein

Structural maintenance of chromosomes protein

Gene

SMC4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes proteinUniRule annotation
Gene namesi
Name:SMC4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14013. SMC4.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

EPDiE9PD53.
PaxDbiE9PD53.
PeptideAtlasiE9PD53.
PRIDEiE9PD53.

Expressioni

Gene expression databases

BgeeiE9PD53.
ExpressionAtlasiE9PD53. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiE9PD53. 1 interaction.
MINTiMINT-8395027.
STRINGi9606.ENSP00000341382.

Structurei

3D structure databases

ProteinModelPortaliE9PD53.
SMRiE9PD53. Positions 547-742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini588 – 703116SMC_hingeInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili302 – 35049Sequence analysisAdd
BLAST
Coiled coili372 – 40635Sequence analysisAdd
BLAST
Coiled coili414 – 45946Sequence analysisAdd
BLAST
Coiled coili516 – 55035Sequence analysisAdd
BLAST
Coiled coili744 – 82077Sequence analysisAdd
BLAST
Coiled coili874 – 985112Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SMC family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0996. Eukaryota.
COG1196. LUCA.
GeneTreeiENSGT00580000081617.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PD53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKGTQPST ARRREEGPPP PSPDGASSDA EPEPPSGRTE SPATAAAMTN
60 70 80 90 100
EAGAPRLMIT HIVNQNFKSY AGEKILGPFH KRFSCIIGPN GSGKSNVIDS
110 120 130 140 150
MLFVFGYRAQ KIRSKKLSVL IHNSDEHKDI QSCTVEVHFQ KIIDKEGDDY
160 170 180 190 200
EVIPNSNFYV SRTACRDNTS VYHISGKKKT FKDVGNLLRS HGIDLDHNRF
210 220 230 240 250
LILQGEVEQI AMMKPKGQTE HDEGMLEYLE DIIGCGRLNE PIKVLCRRVE
260 270 280 290 300
ILNEHRGEKL NRVKMVEKEK DALEGEKNIA IEFLTLENEI FRKKNHVCQY
310 320 330 340 350
YIYELQKRIA EMETQKEKIH EDTKEINEKS NILSNEMKAK NKDVKDTEKK
360 370 380 390 400
LNKITKFIEE NKEKFTQLDL EDVQVREKLK HATSKAKKLE KQLQKDKEKV
410 420 430 440 450
EEFKSIPAKS NNIINETTTR NNALEKEKEK EEKKLKEVMD SLKQETQGLQ
460 470 480 490 500
KEKESREKEL MGFSKSVNEA RSKMDVAQSE LDIYLSRHNT AVSQLTKAKE
510 520 530 540 550
ALIAASETLK ERKAAIRDIE GKLPQTEQEL KEKEKELQKL TQEETNFKSL
560 570 580 590 600
VHDLFQKVEE AKSSLAMNRS RGKVLDAIIQ EKKSGRIPGI YGRLGDLGAI
610 620 630 640 650
DEKYDVAISS CCHALDYIVV DSIDIAQECV NFLKRQNIGV ATFIGLDKMA
660 670 680 690 700
VWAKKMTEIQ TPENTPRLFD LVKVKDEKIR QAFYFALRDT LVADNLDQAT
710 720 730 740 750
RVAYQKDRRW RVVTLQGQII EQSGTMTGGG SKVMKGRMGS SLVIEISEEE
760 770 780 790 800
VNKMESQLQN DSKKAMQIQE QKVQLEERVV KLRHSEREMR NTLEKFTASI
810 820 830 840 850
QRLIEQEEYL NVQVKELEAN VLATAPDKKK QKLLEENVSA FKTEYDAVAE
860 870 880 890 900
KAGKVEAEVK RLHNTIVEIN NHKLKAQQDK LDKINKQLDE CASAITKAQV
910 920 930 940 950
AIKTADRNLQ KAQDSVLRTE KEIKDTEKEV DDLTAELKSL EDKAAEVVKN
960 970 980 990 1000
TNAAEESLPE IQKEHRNLLQ ELKVIQENEH ALQKDALSIK LKLEQIDGHI
1010 1020 1030 1040 1050
AEHNSKIKYW HKEISKISLH PIEDNPIEEI SVLSPEDLEA IKNPDSITNQ
1060 1070 1080 1090 1100
IALLEARCHE MKPNLGAIAE YKKKEELYLQ RVAELDKITY ERDSFRQAYE
1110 1120 1130 1140 1150
DLRKQRLNEF MAGFYIITNK LKENYQMLTL GGDAELELVD SLDPFSEGIM
1160 1170 1180 1190 1200
FSVRPPKKSW KKIFNLSGGE KTLSSLALVF ALHHYKPTPL YFMDEIDAAL
1210 1220 1230 1240 1250
DFKNVSIVAF YIYEQTKNAQ FIIISLRNNM FEISDRLIGI YKTYNITKSV
1260
AVNPKEIASK GLC
Length:1,263
Mass (Da):144,455
Last modified:April 5, 2011 - v1
Checksum:iED10EB5CBA2E848D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024221 Genomic DNA. No translation available.
RefSeqiNP_001275682.1. NM_001288753.1.
UniGeneiHs.58992.

Genome annotation databases

EnsembliENST00000469762; ENSP00000417964; ENSG00000113810.
GeneIDi10051.
UCSCiuc003fdi.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024221 Genomic DNA. No translation available.
RefSeqiNP_001275682.1. NM_001288753.1.
UniGeneiHs.58992.

3D structure databases

ProteinModelPortaliE9PD53.
SMRiE9PD53. Positions 547-742.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9PD53. 1 interaction.
MINTiMINT-8395027.
STRINGi9606.ENSP00000341382.

Proteomic databases

EPDiE9PD53.
PaxDbiE9PD53.
PeptideAtlasiE9PD53.
PRIDEiE9PD53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000469762; ENSP00000417964; ENSG00000113810.
GeneIDi10051.
UCSCiuc003fdi.5. human.

Organism-specific databases

CTDi10051.
HGNCiHGNC:14013. SMC4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0996. Eukaryota.
COG1196. LUCA.
GeneTreeiENSGT00580000081617.

Miscellaneous databases

GenomeRNAii10051.

Gene expression databases

BgeeiE9PD53.
ExpressionAtlasiE9PD53. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  10. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE9PD53_HUMAN
AccessioniPrimary (citable) accession number: E9PD53
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.