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Protein
Submitted name:

Cellular tumor antigen p53

Gene

TP53

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Cellular tumor antigen p53Imported
Gene namesi
Name:TP53Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141510.16.
HGNCiHGNC:11998. TP53.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141510.

PTM / Processingi

Proteomic databases

PaxDbiE9PCY9.
PeptideAtlasiE9PCY9.
PRIDEiE9PCY9.

Expressioni

Gene expression databases

BgeeiENSG00000141510.
ExpressionAtlasiE9PCY9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PCY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 29P53_TADInterPro annotationAdd BLAST25
Domaini95 – 127P53InterPro annotationAdd BLAST33

Phylogenomic databases

eggNOGiENOG410IITK. Eukaryota.
ENOG410ZSWV. LUCA.
GeneTreeiENSGT00390000015092.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiView protein in Pfam
PF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
SUPFAMiSSF49417. SSF49417. 1 hit.

Sequencei

Sequence statusi: Fragment.

E9PCY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI
60 70 80 90 100
EQWFTEDPGP DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ
110 120
KTYQGSYGFR LGFLHSGTAK SVTCTYS
Length:127
Mass (Da):13,594
Last modified:October 5, 2016 - v8
Checksum:i8C422711C0DA5E3F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei127Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007421 Genomic DNA. No translation available.
AC087388 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000503591; ENSP00000426252; ENSG00000141510.
UCSCiuc060avd.1. human.

Similar proteinsi

Entry informationi

Entry nameiE9PCY9_HUMAN
AccessioniPrimary (citable) accession number: E9PCY9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 5, 2016
Last modified: September 27, 2017
This is version 53 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported