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1 to 25 of 43  Show
  1. 1
    "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 8168 other entries.

  2. 2
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 5532 other entries.

  3. 3
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).
  4. 4
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 8512 other entries.

  5. 5
    Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Source: UniProtKB/TrEMBL (unreviewed).
  6. 6
    "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 12978 other entries.

  7. 7
    "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 11209 other entries.

  8. 8
    "The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2."
    Paugh S.W., Payne S.G., Barbour S.E., Milstien S., Spiegel S.
    FEBS Lett. 554:189-193(2003) [PubMed] [Europe PMC] [Abstract]
    Annotation: although both sphingosine kinase type 1 (SphK1) and type 2 (SphK2) can phosphorylate FTY720 with low efficiency SphK2 is much more effective than SphK1Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 6 other entries.

  9. 9
    "Role of sphingosine kinase 2 in cell migration toward epidermal growth factor."
    Hait N.C., Sarkar S., Le Stunff H., Mikami A., Maceyka M., Milstien S., Spiegel S.
    J. Biol. Chem. 280:29462-29469(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: Sphingosine kinase 2 plays an important role in migration of MDA-MB-453 cells toward EGF.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 6 other entries.

  10. 10
    "Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis."
    Okada T., Ding G., Sonoda H., Kajimoto T., Haga Y., Khosrowbeygi A., Gao S., Miwa N., Jahangeer S., Nakamura S.
    J. Biol. Chem. 280:36318-36325(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: the N-terminal-extended form of sphingosine kinase 2 has a role in serum-dependent regulation of cell proliferation and apoptosisImported.
    Source: GeneRIF:56848.

    This publication is mapped to 9 other entries.

  11. 11
    "Sphingosine kinase type 2 activation by ERK-mediated phosphorylation."
    Hait N.C., Bellamy A., Milstien S., Kordula T., Spiegel S.
    J. Biol. Chem. 282:12058-12065(2007) [PubMed] [Europe PMC] [Abstract]
    Annotation: hSphK2 is phosphorylated on Ser-351 and Thr-578 by ERK1 and phosphorylation of these residues is important for EGF-stimulated migration of MDA-MB-453 cellsImported.
    Source: GeneRIF:56848.

    This publication is mapped to 15 other entries.

  12. 12
    "Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2."
    Ding G., Sonoda H., Yu H., Kajimoto T., Goparaju S.K., Jahangeer S., Okada T., Nakamura S.
    J. Biol. Chem. 282:27493-27502(2007) [PubMed] [Europe PMC] [Abstract]
    Annotation: PKD is a physiologically relevant enzyme for SPHK2 phosphorylation which leads to its nuclear export for subsequent cellular signaling.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 9 other entries.

  13. 13
    "Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2."
    Le Stunff H., Giussani P., Maceyka M., Lepine S., Milstien S., Spiegel S.
    J. Biol. Chem. 282:34372-34380(2007) [PubMed] [Europe PMC] [Abstract]
    Annotation: Sphingosine kinase 2 but not sphingosine kinase 1 acted in concert with SPP-1 to regulate recycling of sphingosine into ceramide.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 8 other entries.

  14. 14
    "Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions."
    Oskeritzian C.A., Alvarez S.E., Hait N.C., Price M.M., Milstien S., Spiegel S.
    Blood 111:4193-4200(2008) [PubMed] [Europe PMC] [Abstract]
    Annotation: These data suggest that differential formation of sphingosine-1-phosphate by SphK1 and SphK2 has distinct and important actions in human mast cells.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 11 other entries.

  15. 15
    "Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity."
    Leclercq T.M., Moretti P.A., Vadas M.A., Pitson S.M.
    J. Biol. Chem. 283:9606-9614(2008) [PubMed] [Europe PMC] [Abstract]
    Annotation: a novel mechanism of regulation of both SK1 and SK2 that is mediated by their interaction with eEF1A.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 11 other entries.

  16. 16
    "A lipid binding domain in sphingosine kinase 2."
    Don A.S., Rosen H.
    Biochem. Biophys. Res. Commun. 380:87-92(2009) [PubMed] [Europe PMC] [Abstract]
    Annotation: A lipid binding domain in Sphk2 that is important for the enzyme's sub-cellular localisation was identified.Imported.
    Source: GeneRIF:56848.

    This publication is cited by 1 and mapped to 5 other entries.

  17. 17
    "Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation."
    Nemoto S., Nakamura M., Osawa Y., Kono S., Itoh Y., Okano Y., Murate T., Hara A., Ueda H., Nozawa Y., Banno Y.
    J. Biol. Chem. 284:10422-10432(2009) [PubMed] [Europe PMC] [Abstract]
    Annotation: Results indicate that SPHK1 and 2 isoforms and neutral sphingomyelinase contribute to the regulation of chemosensitivity by controlling ceramide formation and the downstream Akt pathway in human colon cancer cells.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 11 other entries.

  18. 18
    "Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720."
    Kamada K., Arita N., Tsubaki T., Takubo N., Fujino T., Soga Y., Miyazaki T., Yamamoto H., Nose M.
    Pathol. Int. 59:382-389(2009) [PubMed] [Europe PMC] [Abstract]
    Annotation: SPHK2 may regulate the autonomous proliferation of synovial fibroblasts as one of the predisposing genes to rheumatoid arthritisImported.
    Source: GeneRIF:56848.

    This publication is mapped to 6 other entries.

  19. 19
    "Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells."
    Weigert A., Cremer S., Schmidt M.V., von Knethen A., Angioni C., Geisslinger G., Brune B.
    Blood 115:3531-3540(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 18 other entries.

  20. 20
    "New genetic associations detected in a host response study to hepatitis B vaccine."
    Davila S., Froeling F.E., Tan A., Bonnard C., Boland G.J., Snippe H., Hibberd M.L., Seielstad M.
    Genes Immun. 11:232-238(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 17679 other entries.

  21. 21
    "Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2."
    Antoon J.W., White M.D., Slaughter E.M., Driver J.L., Khalili H.S., Elliott S., Smith C.D., Burow M.E., Beckman B.S.
    Cancer Biol. Ther. 11:678-689(2011) [PubMed] [Europe PMC] [Abstract]
    Annotation: pharmacological inhibition of Sphk2 with the orally bioavailable selective inhibitor ABC294640 has therapeutic potential in the treatment of chemo- and endocrine therapy- resistant breast cancer.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 6 other entries.

  22. 22
    "(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells."
    Lim K.G., Sun C., Bittman R., Pyne N.J., Pyne S.
    Cell. Signal. 23:1590-1595(2011) [PubMed] [Europe PMC] [Abstract]
    Annotation: SK2 functions as a pro-survival protein and is involved in promoting actin rearrangement into membrane ruffles/lamellipodia in response to sphingosine 1-phosphate in MCF-7 breast cancer cells.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 6 other entries.

  23. 23
    "The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells."
    Watson D.G., Tonelli F., Alossaimi M., Williamson L., Chan E., Gorshkova I., Berdyshev E., Bittman R., Pyne N.J., Pyne S.
    Cell. Signal. 25:1011-1017(2013) [PubMed] [Europe PMC] [Abstract]
    Annotation: Sphingosine kinase 2 might function simply to dynamically regulate sphingosine-S1P cycling.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 11 other entries.

  24. 24
    "Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined."
    Dillahunt S.E., Sargent J.L., Suzuki R., Proia R.L., Gilfillan A., Rivera J., Olivera A.
    J. Immunol. 190:2058-2067(2013) [PubMed] [Europe PMC] [Abstract]
    Annotation: The function of SphK1 and SphK2 can be interchangeable in mast cells and is species and cell type determined.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 23 other entries.

  25. 25
    "Sphingosine kinase 2: a controversial role in arthritis."
    Xu T., Li L., Huang C., Peng Y., Li J.
    Rheumatol. Int. 34:1015-1016(2014) [PubMed] [Europe PMC] [Abstract]
    Annotation: SphK2 plays a controversial role in arthritis.Imported.
    Source: GeneRIF:56848.

    This publication is mapped to 6 other entries.

1 to 25 of 43  Show