Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Sphingosine kinase 2

Gene

SPHK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Sphingosine kinase 2Imported
Submitted name:
Sphingosine kinase 2, isoform CRA_eImported
Gene namesi
Name:SPHK2Imported
ORF Names:hCG_15274Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18859. SPHK2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000063176.

PTM / Processingi

Proteomic databases

PeptideAtlasiE9PCV4.

Expressioni

Gene expression databases

BgeeiENSG00000063176.
ExpressionAtlasiE9PCV4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000245222.

Structurei

3D structure databases

ProteinModelPortaliE9PCV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 119DAGKcInterPro annotationAdd BLAST119

Phylogenomic databases

eggNOGiKOG1116. Eukaryota.
COG1597. LUCA.
GeneTreeiENSGT00690000101761.

Family and domain databases

InterProiIPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PCV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISEAGLSFN LIQTERQNHA RELVQGLSLS EWDGIVTVSG DGLLHEVLNG
60 70 80 90 100
LLDRPDWEEA VKMPVGILPC GSGNALAGAV NQHGGFEPAL GLDLLLNCSL
110 120 130 140 150
LLCRGGGHPL DLLSVTLASG SRCFSFLSVA WGFVSDVDIQ SERFRALGSA
160 170 180 190 200
RFTLGTVLGL ATLHTYRGRL SYLPATVEPA SPTPAHSLPR AKSELTLTPD
210 220 230 240 250
PAPPMAHSPL HRSVSDLPLP LPQPALASPG SPEPLPILSL NGGGPELAGD
260 270 280 290 300
WGGAGDAPLS PDPLLSSPPG SPKAALHSPV SEGAPVIPPS SGLPLPTPDA
310 320 330 340 350
RVGASTCGPP DHLLPPLGTP LPPDWVTLEG DFVLMLAISP SHLGADLVAA
360 370 380 390 400
PHARFDDGLV HLCWVRSGIS RAALLRLFLA MERGSHFSLG CPQLGYAAAR
410 420 430 440
AFRLEPLTPR GVLTVDGEQV EYGPLQAQMH PGIGTLLTGP PGCPGREP
Length:448
Mass (Da):46,563
Last modified:October 29, 2014 - v2
Checksum:i9823B293362626FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022154 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52371.1.
RefSeqiNP_001230805.1. NM_001243876.1.
XP_016882498.1. XM_017027009.1.
UniGeneiHs.528006.

Genome annotation databases

EnsembliENST00000340932; ENSP00000341091; ENSG00000063176.
GeneIDi56848.
UCSCiuc002pjt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022154 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52371.1.
RefSeqiNP_001230805.1. NM_001243876.1.
XP_016882498.1. XM_017027009.1.
UniGeneiHs.528006.

3D structure databases

ProteinModelPortaliE9PCV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000245222.

Proteomic databases

PeptideAtlasiE9PCV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340932; ENSP00000341091; ENSG00000063176.
GeneIDi56848.
UCSCiuc002pjt.3. human.

Organism-specific databases

CTDi56848.
HGNCiHGNC:18859. SPHK2.
OpenTargetsiENSG00000063176.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1116. Eukaryota.
COG1597. LUCA.
GeneTreeiENSGT00690000101761.

Miscellaneous databases

ChiTaRSiSPHK2. human.
GenomeRNAii56848.

Gene expression databases

BgeeiENSG00000063176.
ExpressionAtlasiE9PCV4. baseline and differential.

Family and domain databases

InterProiIPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PCV4_HUMAN
AccessioniPrimary (citable) accession number: E9PCV4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 29, 2014
Last modified: November 2, 2016
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.