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E9PCR7

- E9PCR7_HUMAN

UniProt

E9PCR7 - E9PCR7_HUMAN

Protein
Submitted name:

2-oxoglutarate dehydrogenase, mitochondrial

Gene

OGDH

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    2-oxoglutarate dehydrogenase, mitochondrialImported
    Gene namesi
    Name:OGDHImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:8124. OGDH.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: HPA

    PTM / Processingi

    Proteomic databases

    PRIDEiE9PCR7.

    Expressioni

    Gene expression databases

    ArrayExpressiE9PCR7.
    BgeeiE9PCR7.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PCR7.
    SMRiE9PCR7. Positions 130-1029.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK00164.
    OMAiMLSGTHF.
    PhylomeDBiE9PCR7.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E9PCR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFQQIRCY SAPVAAEPFL     50
    SGTSSNYVEE MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS 100
    RGSLAAVAHA QSLVEAQPNV DKLVEDHLAV QSLIRAYQIR GHHVAQLDPL 150
    GILDADLDSS VPADIISSTD KLDLAVFKER LRMLTVGGFY GLDESDLDKV 200
    FHLPTTTFIG GQESALPLRE IIRRLEMAYC QHIGVEFMFI NDLEQCQWIR 250
    QKFETPGIMQ FTNEEKRTLL ARLVRSTRFE EFLQRKWSSE KRFGLEGCEV 300
    LIPALKTIID KSSENGVDYV IMGMPHRGRL NVLANVIRKE LEQIFCQFDS 350
    KLEAADEGSG DVKYHLGMYH RRINRVTDRN ITLSLVANPS HLEAADPVVM 400
    GKTKAEQFYC GDTEGKKVMS ILLHGDAAFA GQGIVYETFH LSDLPSYTTH 450
    GTVHVVVNNQ IGFTTDPRMA RSSPYPTDVA RVVNAPIFHV NSDDPEAVMY 500
    VCKVAAEWRS TFHKDVVVDL VCYRRNGHNE MDEPMFTQPL MYKQIRKQKP 550
    VLQKYAELLV SQGVVNQPEY EEEISKYDKI CEEAFARSKD EKILHIKHWL 600
    DSPWPGFFTL DGQPRSMSCP STGLTEDILT HIGNVASSVP VENFTIHGGL 650
    SRILKTRGEM VKNRTVDWAL AEYMAFGSLL KEGIHIRLSG QDVERGTFSH 700
    RHHVLHDQNV DKRTCIPMNH LWPNQAPYTV CNSSLSEYGV LGFELGFAMA 750
    SPNALVLWEA QFGDFHNTAQ CIIDQFICPG QAKWVRQNGI VLLLPHGMEG 800
    MGPEHSSARP ERFLQMCNDD PDVLPDLKEA NFDINQLYDC NWVVVNCSTP 850
    GNFFHVLRRQ ILLPFRKPLI IFTPKSLLRH PEARSSFDEM LPGTHFQRVI 900
    PEDGPAAQNP ENVKRLLFCT GKVYYDLTRE RKARDMVGQV AITRIEQLSP 950
    FPFDLLLKEV QKYPNAELAW CQEEHKNQGY YDYVKPRLRT TISRAKPVWY 1000
    AGRDPAAAPA TGNKKTHLTE LQRLLDTAFD LDVFKNFS 1038
    Length:1,038
    Mass (Da):117,665
    Last modified:April 5, 2011 - v1
    Checksum:i1BF9B291F8523359
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004859 Genomic DNA. No translation available.
    AC011894 Genomic DNA. No translation available.
    RefSeqiXP_005249816.1. XM_005249759.2.
    UniGeneiHs.488181.

    Genome annotation databases

    EnsembliENST00000444676; ENSP00000414662; ENSG00000105953.
    GeneIDi4967.
    KEGGihsa:4967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004859 Genomic DNA. No translation available.
    AC011894 Genomic DNA. No translation available.
    RefSeqi XP_005249816.1. XM_005249759.2.
    UniGenei Hs.488181.

    3D structure databases

    ProteinModelPortali E9PCR7.
    SMRi E9PCR7. Positions 130-1029.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9PCR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000444676 ; ENSP00000414662 ; ENSG00000105953 .
    GeneIDi 4967.
    KEGGi hsa:4967.

    Organism-specific databases

    CTDi 4967.
    HGNCi HGNC:8124. OGDH.
    GenAtlasi Search...

    Phylogenomic databases

    KOi K00164.
    OMAi MLSGTHF.
    PhylomeDBi E9PCR7.

    Miscellaneous databases

    ChiTaRSi OGDH. human.
    GenomeRNAii 4967.
    NextBioi 35501549.

    Gene expression databases

    ArrayExpressi E9PCR7.
    Bgeei E9PCR7.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiE9PCR7_HUMAN
    AccessioniPrimary (citable) accession number: E9PCR7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3