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E9PCR7

- E9PCR7_HUMAN

UniProt

E9PCR7 - E9PCR7_HUMAN

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Protein
Submitted name:

2-oxoglutarate dehydrogenase, mitochondrial

Gene

OGDH

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase, mitochondrialImported
Gene namesi
Name:OGDHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:8124. OGDH.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9PCR7.

Expressioni

Gene expression databases

BgeeiE9PCR7.
ExpressionAtlasiE9PCR7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PCR7.
SMRiE9PCR7. Positions 130-1029.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063092.
KOiK00164.
OMAiMLSGTHF.
PhylomeDBiE9PCR7.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PCR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFQQIRCY SAPVAAEPFL
60 70 80 90 100
SGTSSNYVEE MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS
110 120 130 140 150
RGSLAAVAHA QSLVEAQPNV DKLVEDHLAV QSLIRAYQIR GHHVAQLDPL
160 170 180 190 200
GILDADLDSS VPADIISSTD KLDLAVFKER LRMLTVGGFY GLDESDLDKV
210 220 230 240 250
FHLPTTTFIG GQESALPLRE IIRRLEMAYC QHIGVEFMFI NDLEQCQWIR
260 270 280 290 300
QKFETPGIMQ FTNEEKRTLL ARLVRSTRFE EFLQRKWSSE KRFGLEGCEV
310 320 330 340 350
LIPALKTIID KSSENGVDYV IMGMPHRGRL NVLANVIRKE LEQIFCQFDS
360 370 380 390 400
KLEAADEGSG DVKYHLGMYH RRINRVTDRN ITLSLVANPS HLEAADPVVM
410 420 430 440 450
GKTKAEQFYC GDTEGKKVMS ILLHGDAAFA GQGIVYETFH LSDLPSYTTH
460 470 480 490 500
GTVHVVVNNQ IGFTTDPRMA RSSPYPTDVA RVVNAPIFHV NSDDPEAVMY
510 520 530 540 550
VCKVAAEWRS TFHKDVVVDL VCYRRNGHNE MDEPMFTQPL MYKQIRKQKP
560 570 580 590 600
VLQKYAELLV SQGVVNQPEY EEEISKYDKI CEEAFARSKD EKILHIKHWL
610 620 630 640 650
DSPWPGFFTL DGQPRSMSCP STGLTEDILT HIGNVASSVP VENFTIHGGL
660 670 680 690 700
SRILKTRGEM VKNRTVDWAL AEYMAFGSLL KEGIHIRLSG QDVERGTFSH
710 720 730 740 750
RHHVLHDQNV DKRTCIPMNH LWPNQAPYTV CNSSLSEYGV LGFELGFAMA
760 770 780 790 800
SPNALVLWEA QFGDFHNTAQ CIIDQFICPG QAKWVRQNGI VLLLPHGMEG
810 820 830 840 850
MGPEHSSARP ERFLQMCNDD PDVLPDLKEA NFDINQLYDC NWVVVNCSTP
860 870 880 890 900
GNFFHVLRRQ ILLPFRKPLI IFTPKSLLRH PEARSSFDEM LPGTHFQRVI
910 920 930 940 950
PEDGPAAQNP ENVKRLLFCT GKVYYDLTRE RKARDMVGQV AITRIEQLSP
960 970 980 990 1000
FPFDLLLKEV QKYPNAELAW CQEEHKNQGY YDYVKPRLRT TISRAKPVWY
1010 1020 1030
AGRDPAAAPA TGNKKTHLTE LQRLLDTAFD LDVFKNFS
Length:1,038
Mass (Da):117,665
Last modified:April 5, 2011 - v1
Checksum:i1BF9B291F8523359
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004859 Genomic DNA. No translation available.
AC011894 Genomic DNA. No translation available.
RefSeqiXP_005249816.1. XM_005249759.2.
UniGeneiHs.488181.

Genome annotation databases

EnsembliENST00000444676; ENSP00000414662; ENSG00000105953.
GeneIDi4967.
KEGGihsa:4967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004859 Genomic DNA. No translation available.
AC011894 Genomic DNA. No translation available.
RefSeqi XP_005249816.1. XM_005249759.2.
UniGenei Hs.488181.

3D structure databases

ProteinModelPortali E9PCR7.
SMRi E9PCR7. Positions 130-1029.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9PCR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000444676 ; ENSP00000414662 ; ENSG00000105953 .
GeneIDi 4967.
KEGGi hsa:4967.

Organism-specific databases

CTDi 4967.
HGNCi HGNC:8124. OGDH.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000063092.
KOi K00164.
OMAi MLSGTHF.
PhylomeDBi E9PCR7.

Miscellaneous databases

ChiTaRSi OGDH. human.
GenomeRNAii 4967.
NextBioi 35501549.

Gene expression databases

Bgeei E9PCR7.
ExpressionAtlasi E9PCR7. baseline and differential.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PCR7_HUMAN
AccessioniPrimary (citable) accession number: E9PCR7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3