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E9PCR7

- E9PCR7_HUMAN

UniProt

E9PCR7 - E9PCR7_HUMAN

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Protein
Submitted name:

2-oxoglutarate dehydrogenase, mitochondrial

Gene
OGDH
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase, mitochondrialImported
Gene namesi
Name:OGDHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:8124. OGDH.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9PCR7.

Expressioni

Gene expression databases

ArrayExpressiE9PCR7.
BgeeiE9PCR7.

Structurei

3D structure databases

ProteinModelPortaliE9PCR7.
SMRiE9PCR7. Positions 130-1029.

Family & Domainsi

Phylogenomic databases

KOiK00164.
OMAiMLSGTHF.
PhylomeDBiE9PCR7.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PCR7-1 [UniParc]FASTAAdd to Basket

« Hide

MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFQQIRCY SAPVAAEPFL     50
SGTSSNYVEE MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS 100
RGSLAAVAHA QSLVEAQPNV DKLVEDHLAV QSLIRAYQIR GHHVAQLDPL 150
GILDADLDSS VPADIISSTD KLDLAVFKER LRMLTVGGFY GLDESDLDKV 200
FHLPTTTFIG GQESALPLRE IIRRLEMAYC QHIGVEFMFI NDLEQCQWIR 250
QKFETPGIMQ FTNEEKRTLL ARLVRSTRFE EFLQRKWSSE KRFGLEGCEV 300
LIPALKTIID KSSENGVDYV IMGMPHRGRL NVLANVIRKE LEQIFCQFDS 350
KLEAADEGSG DVKYHLGMYH RRINRVTDRN ITLSLVANPS HLEAADPVVM 400
GKTKAEQFYC GDTEGKKVMS ILLHGDAAFA GQGIVYETFH LSDLPSYTTH 450
GTVHVVVNNQ IGFTTDPRMA RSSPYPTDVA RVVNAPIFHV NSDDPEAVMY 500
VCKVAAEWRS TFHKDVVVDL VCYRRNGHNE MDEPMFTQPL MYKQIRKQKP 550
VLQKYAELLV SQGVVNQPEY EEEISKYDKI CEEAFARSKD EKILHIKHWL 600
DSPWPGFFTL DGQPRSMSCP STGLTEDILT HIGNVASSVP VENFTIHGGL 650
SRILKTRGEM VKNRTVDWAL AEYMAFGSLL KEGIHIRLSG QDVERGTFSH 700
RHHVLHDQNV DKRTCIPMNH LWPNQAPYTV CNSSLSEYGV LGFELGFAMA 750
SPNALVLWEA QFGDFHNTAQ CIIDQFICPG QAKWVRQNGI VLLLPHGMEG 800
MGPEHSSARP ERFLQMCNDD PDVLPDLKEA NFDINQLYDC NWVVVNCSTP 850
GNFFHVLRRQ ILLPFRKPLI IFTPKSLLRH PEARSSFDEM LPGTHFQRVI 900
PEDGPAAQNP ENVKRLLFCT GKVYYDLTRE RKARDMVGQV AITRIEQLSP 950
FPFDLLLKEV QKYPNAELAW CQEEHKNQGY YDYVKPRLRT TISRAKPVWY 1000
AGRDPAAAPA TGNKKTHLTE LQRLLDTAFD LDVFKNFS 1038
Length:1,038
Mass (Da):117,665
Last modified:April 5, 2011 - v1
Checksum:i1BF9B291F8523359
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004859 Genomic DNA. No translation available.
AC011894 Genomic DNA. No translation available.
RefSeqiXP_005249816.1. XM_005249759.2.
UniGeneiHs.488181.

Genome annotation databases

EnsembliENST00000444676; ENSP00000414662; ENSG00000105953.
GeneIDi4967.
KEGGihsa:4967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004859 Genomic DNA. No translation available.
AC011894 Genomic DNA. No translation available.
RefSeqi XP_005249816.1. XM_005249759.2.
UniGenei Hs.488181.

3D structure databases

ProteinModelPortali E9PCR7.
SMRi E9PCR7. Positions 130-1029.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9PCR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000444676 ; ENSP00000414662 ; ENSG00000105953 .
GeneIDi 4967.
KEGGi hsa:4967.

Organism-specific databases

CTDi 4967.
HGNCi HGNC:8124. OGDH.
GenAtlasi Search...

Phylogenomic databases

KOi K00164.
OMAi MLSGTHF.
PhylomeDBi E9PCR7.

Miscellaneous databases

ChiTaRSi OGDH. human.
GenomeRNAii 4967.
NextBioi 35501549.

Gene expression databases

ArrayExpressi E9PCR7.
Bgeei E9PCR7.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PCR7_HUMAN
AccessioniPrimary (citable) accession number: E9PCR7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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